PPGR - Gene Detail

Basic Information

Gene ID	Bpev01.c4987.g0002 View in Genome Browser
Position	Contig4987:544-987 (-) 443bp
Gene Type	gene
Gene Description (Protein Product)	"Part of the beta sliding clamp loading complex
Organism	Betula pendula
Also AS

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

Bpev01.c5109.g0002 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is

Bpev01.c5416.g0004 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

Bpev01.c5416.g0005 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

Regulatory gene

Bpev01.c0000.g0005 Protein PHR1-LIKE 1-like isoform

Bpev01.c0001.g0043 NAC domain-containing protein

Bpev01.c0015.g0167 Ethylene-responsive transcription factor-like protein

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Expression Profile

DataSet	Number of Samples expressed(TPM>1)	Mean	Min	Max	Standard deviation(SD)	Coeffcient variation(CV)

Select Expression

Pathway

GO Term	Description	GO Category
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0006275	regulation of DNA replication	BP
GO:0008150	biological_process	BP
GO:0009314	response to radiation	BP
GO:0009360	DNA polymerase III complex	CC
GO:0009628	response to abiotic stimulus	BP
GO:0009889	regulation of biosynthetic process	BP
GO:0009891	positive regulation of biosynthetic process	BP
GO:0009893	positive regulation of metabolic process	BP
GO:0010556	regulation of macromolecule biosynthetic process	BP
GO:0010557	positive regulation of macromolecule biosynthetic process	BP
GO:0010604	positive regulation of macromolecule metabolic process	BP
GO:0019219	regulation of nucleobase-containing compound metabolic process	BP
GO:0019222	regulation of metabolic process	BP
GO:0030174	regulation of DNA-templated DNA replication initiation	BP
GO:0031323	regulation of cellular metabolic process	BP
GO:0031325	positive regulation of cellular metabolic process	BP
GO:0031326	regulation of cellular biosynthetic process	BP
GO:0031328	positive regulation of cellular biosynthetic process	BP
GO:0032298	positive regulation of DNA-templated DNA replication initiation	BP
GO:0032991	protein-containing complex	CC
GO:0042575	DNA polymerase complex	CC
GO:0043846	DNA polymerase III, clamp loader complex	CC
GO:0043847	DNA polymerase III, clamp loader chi/psi subcomplex	CC
GO:0044424	obsolete intracellular part	CC
GO:0044464	obsolete cell part	CC
GO:0045740	positive regulation of DNA replication	BP
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	BP
GO:0048518	positive regulation of biological process	BP
GO:0048522	positive regulation of cellular process	BP
GO:0050789	regulation of biological process	BP
GO:0050794	regulation of cellular process	BP
GO:0050896	response to stimulus	BP
GO:0051052	regulation of DNA metabolic process	BP
GO:0051054	positive regulation of DNA metabolic process	BP
GO:0051171	regulation of nitrogen compound metabolic process	BP
GO:0051173	positive regulation of nitrogen compound metabolic process	BP
GO:0060255	regulation of macromolecule metabolic process	BP
GO:0061695	transferase complex, transferring phosphorus-containing groups	CC
GO:0065007	biological regulation	BP
GO:0080090	regulation of primary metabolic process	BP
GO:0090329	regulation of DNA-templated DNA replication	BP
GO:1902494	catalytic complex	CC
GO:1990234	transferase complex	CC
GO:2000105	positive regulation of DNA-templated DNA replication	BP
GO:2000112	regulation of cellular macromolecule biosynthetic process	BP

KEGG Term	Name	Description
map03440	Homologous recombination	Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
map03430	Mismatch repair	DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
map03030	DNA replication	A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.