Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Expresssion
Pathway
Basic Information
Gene ID
CSS0001654.g
View in Genome Browser
Position
Chr14:52332871-52337460 (-)
4589bp
Gene Type
gene
Gene Description (Protein Product)
replication factor C
Organism
Camellia sinensis
Also AS AT1G63160

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
CSS0028817.g Replication factor C subunit
CSS0038151.g Replication factor C subunit
CSS0043529.g Replication factor C subunit
Regulatory gene
CSS0000556.g transcription factor
CSS0000859.g MADS-box transcription factor
CSS0002128.g AP2-like ethylene-responsive transcription factor

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000166 nucleotide binding MF
GO:0000723 telomere maintenance BP
GO:0000731 DNA synthesis involved in DNA repair BP
GO:0003674 molecular_function MF
GO:0005488 binding MF
GO:0005524 ATP binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005654 nucleoplasm CC
GO:0005657 replication fork CC
GO:0005663 DNA replication factor C complex CC
GO:0005694 chromosome CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006260 DNA replication BP
GO:0006261 DNA-templated DNA replication BP
GO:0006275 regulation of DNA replication BP
GO:0006281 DNA repair BP
GO:0006283 transcription-coupled nucleotide-excision repair BP
GO:0006289 nucleotide-excision repair BP
GO:0006296 obsolete nucleotide-excision repair, DNA incision, 5'-to lesion BP
GO:0006297 nucleotide-excision repair, DNA gap filling BP
GO:0006301 postreplication repair BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0006996 organelle organization BP
GO:0007049 cell cycle BP
GO:0008144 obsolete drug binding MF
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009889 regulation of biosynthetic process BP
GO:0009891 positive regulation of biosynthetic process BP
GO:0009893 positive regulation of metabolic process BP
GO:0009987 cellular process BP
GO:0010556 regulation of macromolecule biosynthetic process BP
GO:0010557 positive regulation of macromolecule biosynthetic process BP
GO:0010604 positive regulation of macromolecule metabolic process BP
GO:0016043 cellular component organization BP
GO:0017076 purine nucleotide binding MF
GO:0018130 heterocycle biosynthetic process BP
GO:0019219 regulation of nucleobase-containing compound metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019438 aromatic compound biosynthetic process BP
GO:0019725 cellular homeostasis BP
GO:0019985 translesion synthesis BP
GO:0022402 cell cycle process BP
GO:0030554 adenyl nucleotide binding MF
GO:0031323 regulation of cellular metabolic process BP
GO:0031325 positive regulation of cellular metabolic process BP
GO:0031326 regulation of cellular biosynthetic process BP
GO:0031328 positive regulation of cellular biosynthetic process BP
GO:0031390 Ctf18 RFC-like complex CC
GO:0031974 membrane-enclosed lumen CC
GO:0031981 nuclear lumen CC
GO:0032200 telomere organization BP
GO:0032201 telomere maintenance via semi-conservative replication BP
GO:0032553 ribonucleotide binding MF
GO:0032555 purine ribonucleotide binding MF
GO:0032559 adenyl ribonucleotide binding MF
GO:0032991 protein-containing complex CC
GO:0033260 nuclear DNA replication BP
GO:0033554 cellular response to stress BP
GO:0033683 obsolete nucleotide-excision repair, DNA incision BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0034654 nucleobase-containing compound biosynthetic process BP
GO:0035639 purine ribonucleoside triphosphate binding MF
GO:0036094 small molecule binding MF
GO:0042276 error-prone translesion synthesis BP
GO:0042592 homeostatic process BP
GO:0042769 obsolete DNA damage response, detection of DNA damage BP
GO:0043085 positive regulation of catalytic activity BP
GO:0043167 ion binding MF
GO:0043168 anion binding MF
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0044093 positive regulation of molecular function BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044271 cellular nitrogen compound biosynthetic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044427 obsolete chromosomal part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0044786 cell cycle DNA replication BP
GO:0045935 positive regulation of nucleobase-containing compound metabolic process BP
GO:0046483 heterocycle metabolic process BP
GO:0048518 positive regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0050789 regulation of biological process BP
GO:0050790 regulation of catalytic activity BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051052 regulation of DNA metabolic process BP
GO:0051054 positive regulation of DNA metabolic process BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051173 positive regulation of nitrogen compound metabolic process BP
GO:0051276 chromosome organization BP
GO:0051338 regulation of transferase activity BP
GO:0051347 positive regulation of transferase activity BP
GO:0051606 detection of stimulus BP
GO:0051716 cellular response to stimulus BP
GO:0060249 anatomical structure homeostasis BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0065007 biological regulation BP
GO:0065008 regulation of biological quality BP
GO:0065009 regulation of molecular function BP
GO:0070013 intracellular organelle lumen CC
GO:0070987 error-free translesion synthesis BP
GO:0071704 organic substance metabolic process BP
GO:0071840 cellular component organization or biogenesis BP
GO:0071897 DNA biosynthetic process BP
GO:0080090 regulation of primary metabolic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0090305 nucleic acid phosphodiester bond hydrolysis BP
GO:0090329 regulation of DNA-templated DNA replication BP
GO:0097159 organic cyclic compound binding MF
GO:0097367 carbohydrate derivative binding MF
GO:1900262 regulation of DNA-directed DNA polymerase activity BP
GO:1900264 positive regulation of DNA-directed DNA polymerase activity BP
GO:1901265 nucleoside phosphate binding MF
GO:1901360 organic cyclic compound metabolic process BP
GO:1901362 organic cyclic compound biosynthetic process BP
GO:1901363 heterocyclic compound binding MF
GO:1901576 organic substance biosynthetic process BP
GO:2000112 regulation of cellular macromolecule biosynthetic process BP
GO:2000278 regulation of DNA biosynthetic process BP
GO:2000573 positive regulation of DNA biosynthetic process BP
KEGG Term Name Description
map03430 Mismatch repair DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
map03420 Nucleotide excision repair Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
map03030 DNA replication A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.