Basic Information
Gene ID
Position
Contig1039:576367-584754 (+)
8387bp
Gene Type
gene
Gene Description (Protein Product)
Protein BREAST CANCER SUSCEPTIBILITY 1 homolog
Organism
Also AS AT4G21070

Gene Structure

upstream:

Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
CSS0042379.g BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
CSS0042561.g Anaphase-promoting complex subunit
CSS0045658.g Component of the peroxisomal and mitochondrial division machineries. Plays a role in promoting the fission of mitochondria and peroxisomes

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
GO Term Description GO Category
GO:0000151 ubiquitin ligase complex CC
GO:0000152 nuclear ubiquitin ligase complex CC
GO:0000724 double-strand break repair via homologous recombination BP
GO:0000725 recombinational repair BP
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0004842 ubiquitin-protein transferase activity MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005886 plasma membrane CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006281 DNA repair BP
GO:0006302 double-strand break repair BP
GO:0006310 DNA recombination BP
GO:0006355 regulation of DNA-templated transcription BP
GO:0006357 regulation of transcription by RNA polymerase II BP
GO:0006464 protein modification process BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009314 response to radiation BP
GO:0009628 response to abiotic stimulus BP
GO:0009889 regulation of biosynthetic process BP
GO:0009890 negative regulation of biosynthetic process BP
GO:0009891 positive regulation of biosynthetic process BP
GO:0009892 negative regulation of metabolic process BP
GO:0009893 positive regulation of metabolic process BP
GO:0009987 cellular process BP
GO:0010212 response to ionizing radiation BP
GO:0010332 response to gamma radiation BP
GO:0010468 regulation of gene expression BP
GO:0010556 regulation of macromolecule biosynthetic process BP
GO:0010557 positive regulation of macromolecule biosynthetic process BP
GO:0010564 regulation of cell cycle process BP
GO:0010565 regulation of cellular ketone metabolic process BP
GO:0010604 positive regulation of macromolecule metabolic process BP
GO:0010605 negative regulation of macromolecule metabolic process BP
GO:0010628 positive regulation of gene expression BP
GO:0010638 positive regulation of organelle organization BP
GO:0010639 negative regulation of organelle organization BP
GO:0016020 membrane CC
GO:0016567 protein ubiquitination BP
GO:0016740 transferase activity MF
GO:0019216 regulation of lipid metabolic process BP
GO:0019217 regulation of fatty acid metabolic process BP
GO:0019219 regulation of nucleobase-containing compound metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019538 protein metabolic process BP
GO:0019787 ubiquitin-like protein transferase activity MF
GO:0031056 regulation of histone modification BP
GO:0031057 negative regulation of histone modification BP
GO:0031058 positive regulation of histone modification BP
GO:0031323 regulation of cellular metabolic process BP
GO:0031324 negative regulation of cellular metabolic process BP
GO:0031325 positive regulation of cellular metabolic process BP
GO:0031326 regulation of cellular biosynthetic process BP
GO:0031327 negative regulation of cellular biosynthetic process BP
GO:0031328 positive regulation of cellular biosynthetic process BP
GO:0031399 regulation of protein modification process BP
GO:0031400 negative regulation of protein modification process BP
GO:0031401 positive regulation of protein modification process BP
GO:0031436 BRCA1-BARD1 complex CC
GO:0032268 regulation of protein metabolic process BP
GO:0032269 negative regulation of protein metabolic process BP
GO:0032270 positive regulation of protein metabolic process BP
GO:0032446 protein modification by small protein conjugation BP
GO:0032991 protein-containing complex CC
GO:0033043 regulation of organelle organization BP
GO:0033044 regulation of chromosome organization BP
GO:0033554 cellular response to stress BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0035065 regulation of histone acetylation BP
GO:0035066 positive regulation of histone acetylation BP
GO:0035067 negative regulation of histone acetylation BP
GO:0036211 protein modification process BP
GO:0042127 regulation of cell population proliferation BP
GO:0042304 regulation of fatty acid biosynthetic process BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043412 macromolecule modification BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044267 protein metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0045717 negative regulation of fatty acid biosynthetic process BP
GO:0045787 positive regulation of cell cycle BP
GO:0045833 negative regulation of lipid metabolic process BP
GO:0045893 positive regulation of DNA-templated transcription BP
GO:0045922 negative regulation of fatty acid metabolic process BP
GO:0045935 positive regulation of nucleobase-containing compound metabolic process BP
GO:0045944 positive regulation of transcription by RNA polymerase II BP
GO:0046483 heterocycle metabolic process BP
GO:0046890 regulation of lipid biosynthetic process BP
GO:0048518 positive regulation of biological process BP
GO:0048519 negative regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0048523 negative regulation of cellular process BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051055 negative regulation of lipid biosynthetic process BP
GO:0051128 regulation of cellular component organization BP
GO:0051129 negative regulation of cellular component organization BP
GO:0051130 positive regulation of cellular component organization BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051172 negative regulation of nitrogen compound metabolic process BP
GO:0051173 positive regulation of nitrogen compound metabolic process BP
GO:0051246 regulation of protein metabolic process BP
GO:0051247 positive regulation of protein metabolic process BP
GO:0051248 negative regulation of protein metabolic process BP
GO:0051252 regulation of RNA metabolic process BP
GO:0051254 positive regulation of RNA metabolic process BP
GO:0051716 cellular response to stimulus BP
GO:0051726 regulation of cell cycle BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0062012 regulation of small molecule metabolic process BP
GO:0062014 negative regulation of small molecule metabolic process BP
GO:0065007 biological regulation BP
GO:0070531 BRCA1-A complex CC
GO:0070647 protein modification by small protein conjugation or removal BP
GO:0071156 regulation of cell cycle BP
GO:0071158 regulation of cell cycle BP
GO:0071214 cellular response to abiotic stimulus BP
GO:0071478 cellular response to radiation BP
GO:0071479 cellular response to ionizing radiation BP
GO:0071480 cellular response to gamma radiation BP
GO:0071704 organic substance metabolic process BP
GO:0071944 cell periphery CC
GO:0080090 regulation of primary metabolic process BP
GO:0090068 positive regulation of cell cycle process BP
GO:0090304 nucleic acid metabolic process BP
GO:0104004 cellular response to environmental stimulus BP
GO:0140096 catalytic activity, acting on a protein MF
GO:1901360 organic cyclic compound metabolic process BP
GO:1901564 organonitrogen compound metabolic process BP
GO:1901983 regulation of protein acetylation BP
GO:1901984 negative regulation of protein acetylation BP
GO:1901985 positive regulation of protein acetylation BP
GO:1902275 regulation of chromatin organization BP
GO:1902494 catalytic complex CC
GO:1902680 positive regulation of RNA biosynthetic process BP
GO:1903506 regulation of nucleic acid-templated transcription BP
GO:1903508 positive regulation of nucleic acid-templated transcription BP
GO:1905268 negative regulation of chromatin organization BP
GO:1905269 positive regulation of chromatin organization BP
GO:1990234 transferase complex CC
GO:2000112 regulation of cellular macromolecule biosynthetic process BP
GO:2000756 regulation of peptidyl-lysine acetylation BP
GO:2000757 negative regulation of peptidyl-lysine acetylation BP
GO:2000758 positive regulation of peptidyl-lysine acetylation BP
GO:2001141 regulation of RNA biosynthetic process BP
GO:2001251 negative regulation of chromosome organization BP
GO:2001252 positive regulation of chromosome organization BP
KEGG Term Name Description
map03440 Homologous recombination Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.