Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0000151 | ubiquitin ligase complex | CC |
| GO:0003674 | molecular_function | MF |
| GO:0003676 | nucleic acid binding | MF |
| GO:0003677 | DNA binding | MF |
| GO:0003684 | damaged DNA binding | MF |
| GO:0005488 | binding | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005634 | nucleus | CC |
| GO:0006139 | nucleobase-containing compound metabolic process | BP |
| GO:0006259 | DNA metabolic process | BP |
| GO:0006281 | DNA repair | BP |
| GO:0006725 | cellular aromatic compound metabolic process | BP |
| GO:0006807 | nitrogen compound metabolic process | BP |
| GO:0006950 | response to stress | BP |
| GO:0006974 | cellular response to DNA damage stimulus | BP |
| GO:0008150 | biological_process | BP |
| GO:0008152 | metabolic process | BP |
| GO:0009314 | response to radiation | BP |
| GO:0009411 | response to UV | BP |
| GO:0009416 | response to light stimulus | BP |
| GO:0009628 | response to abiotic stimulus | BP |
| GO:0009987 | cellular process | BP |
| GO:0010224 | response to UV-B | BP |
| GO:0031461 | cullin-RING ubiquitin ligase complex | CC |
| GO:0032991 | protein-containing complex | CC |
| GO:0033554 | cellular response to stress | BP |
| GO:0034641 | cellular nitrogen compound metabolic process | BP |
| GO:0043170 | macromolecule metabolic process | BP |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043231 | intracellular membrane-bounded organelle | CC |
| GO:0044237 | cellular metabolic process | BP |
| GO:0044238 | primary metabolic process | BP |
| GO:0044260 | cellular macromolecule metabolic process | BP |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0046483 | heterocycle metabolic process | BP |
| GO:0050896 | response to stimulus | BP |
| GO:0051716 | cellular response to stimulus | BP |
| GO:0071704 | organic substance metabolic process | BP |
| GO:0080008 | Cul4-RING E3 ubiquitin ligase complex | CC |
| GO:0090304 | nucleic acid metabolic process | BP |
| GO:0097159 | organic cyclic compound binding | MF |
| GO:1901360 | organic cyclic compound metabolic process | BP |
| GO:1901363 | heterocyclic compound binding | MF |
| GO:1902494 | catalytic complex | CC |
| GO:1990234 | transferase complex | CC |
| KEGG Term | Name | Description |
|---|---|---|
| map04120 | Ubiquitin mediated proteolysis | Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. |
| map03420 | Nucleotide excision repair | Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar. |