Basic Information
Gene ID
Position
Chr10:29174152-29175488 (-)
1336bp
Gene Type
gene
Gene Description (Protein Product)
DNA ligase
Organism
Also AS AT5G57160

Gene Structure

upstream:

Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
CSS0048376.g DNA polymerase
CSS0045945.g ATP-dependent DNA helicase 2 subunit
CSS0047603.g serine threonine-protein kinase
Regulatory gene
CSS0004712.g GAGA binding protein-like family
CSS0007067.g Protein BASIC PENTACYSTEINE6-like
CSS0008658.g Protein BASIC PENTACYSTEINE2-like

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
GO Term Description GO Category
GO:0000726 obsolete non-recombinational repair BP
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0003909 DNA ligase activity MF
GO:0003910 DNA ligase (ATP) activity MF
GO:0005575 cellular_component CC
GO:0005576 extracellular region CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005737 cytoplasm CC
GO:0005911 cell-cell junction CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006266 DNA ligation BP
GO:0006281 DNA repair BP
GO:0006289 nucleotide-excision repair BP
GO:0006297 nucleotide-excision repair, DNA gap filling BP
GO:0006302 double-strand break repair BP
GO:0006303 double-strand break repair via nonhomologous end joining BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009314 response to radiation BP
GO:0009506 plasmodesma CC
GO:0009628 response to abiotic stimulus BP
GO:0009987 cellular process BP
GO:0010165 response to X-ray BP
GO:0010212 response to ionizing radiation BP
GO:0016874 ligase activity MF
GO:0016886 ligase activity, forming phosphoric ester bonds MF
GO:0030054 cell junction CC
GO:0032807 DNA ligase IV complex CC
GO:0032991 protein-containing complex CC
GO:0033554 cellular response to stress BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0046483 heterocycle metabolic process BP
GO:0048046 apoplast CC
GO:0050896 response to stimulus BP
GO:0051103 DNA ligation involved in DNA repair BP
GO:0051716 cellular response to stimulus BP
GO:0055044 symplast CC
GO:0071704 organic substance metabolic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0140097 catalytic activity, acting on DNA MF
GO:1901360 organic cyclic compound metabolic process BP
KEGG Term Name Description
map03450 Non-homologous end-joining Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.