Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0000726 | obsolete non-recombinational repair | BP |
| GO:0003674 | molecular_function | MF |
| GO:0003824 | catalytic activity | MF |
| GO:0003909 | DNA ligase activity | MF |
| GO:0003910 | DNA ligase (ATP) activity | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005576 | extracellular region | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005634 | nucleus | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005911 | cell-cell junction | CC |
| GO:0006139 | nucleobase-containing compound metabolic process | BP |
| GO:0006259 | DNA metabolic process | BP |
| GO:0006266 | DNA ligation | BP |
| GO:0006281 | DNA repair | BP |
| GO:0006289 | nucleotide-excision repair | BP |
| GO:0006297 | nucleotide-excision repair, DNA gap filling | BP |
| GO:0006302 | double-strand break repair | BP |
| GO:0006303 | double-strand break repair via nonhomologous end joining | BP |
| GO:0006725 | cellular aromatic compound metabolic process | BP |
| GO:0006807 | nitrogen compound metabolic process | BP |
| GO:0006950 | response to stress | BP |
| GO:0006974 | cellular response to DNA damage stimulus | BP |
| GO:0008150 | biological_process | BP |
| GO:0008152 | metabolic process | BP |
| GO:0009314 | response to radiation | BP |
| GO:0009506 | plasmodesma | CC |
| GO:0009628 | response to abiotic stimulus | BP |
| GO:0009987 | cellular process | BP |
| GO:0010165 | response to X-ray | BP |
| GO:0010212 | response to ionizing radiation | BP |
| GO:0016874 | ligase activity | MF |
| GO:0016886 | ligase activity, forming phosphoric ester bonds | MF |
| GO:0030054 | cell junction | CC |
| GO:0032807 | DNA ligase IV complex | CC |
| GO:0032991 | protein-containing complex | CC |
| GO:0033554 | cellular response to stress | BP |
| GO:0034641 | cellular nitrogen compound metabolic process | BP |
| GO:0043170 | macromolecule metabolic process | BP |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043231 | intracellular membrane-bounded organelle | CC |
| GO:0044237 | cellular metabolic process | BP |
| GO:0044238 | primary metabolic process | BP |
| GO:0044260 | cellular macromolecule metabolic process | BP |
| GO:0044422 | obsolete organelle part | CC |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044428 | obsolete nuclear part | CC |
| GO:0044446 | obsolete intracellular organelle part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0046483 | heterocycle metabolic process | BP |
| GO:0048046 | apoplast | CC |
| GO:0050896 | response to stimulus | BP |
| GO:0051103 | DNA ligation involved in DNA repair | BP |
| GO:0051716 | cellular response to stimulus | BP |
| GO:0055044 | symplast | CC |
| GO:0071704 | organic substance metabolic process | BP |
| GO:0090304 | nucleic acid metabolic process | BP |
| GO:0140097 | catalytic activity, acting on DNA | MF |
| GO:1901360 | organic cyclic compound metabolic process | BP |
| KEGG Term | Name | Description |
|---|---|---|
| map03450 | Non-homologous end-joining | Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone. |

