Basic Information
Gene ID
geneMaker00007990
Position
GWHBGXC00000010:21669499-21718863 (+)
49364bp
Gene Type
gene
Gene Description (Protein Product)
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT); an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover; which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance
Organism
Also AS AT5G54770

Gene Structure

upstream:

Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
geneMaker00021793 RbcX protein
geneMaker00024310 Hydroxyethylthiazole kinase
geneMaker00011782 RbcX protein

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
GO Term Description GO Category
GO:0003674 molecular_function MF
GO:0005488 binding MF
GO:0005506 iron ion binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005737 cytoplasm CC
GO:0005739 mitochondrion CC
GO:0005829 cytosol CC
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006766 vitamin metabolic process BP
GO:0006767 water-soluble vitamin metabolic process BP
GO:0006772 thiamine metabolic process BP
GO:0006790 sulfur compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008270 zinc ion binding MF
GO:0009058 biosynthetic process BP
GO:0009110 vitamin biosynthetic process BP
GO:0009228 thiamine biosynthetic process BP
GO:0009266 response to temperature stimulus BP
GO:0009409 response to cold BP
GO:0009507 chloroplast CC
GO:0009526 plastid envelope CC
GO:0009532 plastid stroma CC
GO:0009536 plastid CC
GO:0009570 chloroplast stroma CC
GO:0009579 thylakoid CC
GO:0009628 response to abiotic stimulus BP
GO:0009941 chloroplast envelope CC
GO:0009987 cellular process BP
GO:0010319 stromule CC
GO:0017144 xenobiotic metabolic process BP
GO:0018130 heterocycle biosynthetic process BP
GO:0018131 oxazole or thiazole biosynthetic process BP
GO:0019438 aromatic compound biosynthetic process BP
GO:0019904 protein domain specific binding MF
GO:0031967 organelle envelope CC
GO:0031975 envelope CC
GO:0033554 cellular response to stress BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0042364 water-soluble vitamin biosynthetic process BP
GO:0042723 thiamine-containing compound metabolic process BP
GO:0042724 thiamine-containing compound biosynthetic process BP
GO:0042802 identical protein binding MF
GO:0042803 protein homodimerization activity MF
GO:0043167 ion binding MF
GO:0043169 cation binding MF
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0044237 cellular metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044271 cellular nitrogen compound biosynthetic process BP
GO:0044272 sulfur compound biosynthetic process BP
GO:0044281 small molecule metabolic process BP
GO:0044283 small molecule biosynthetic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044434 obsolete chloroplast part CC
GO:0044435 obsolete plastid part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0046483 heterocycle metabolic process BP
GO:0046484 oxazole or thiazole metabolic process BP
GO:0046872 metal ion binding MF
GO:0046914 transition metal ion binding MF
GO:0046983 protein dimerization activity MF
GO:0050896 response to stimulus BP
GO:0051716 cellular response to stimulus BP
GO:0052837 thiazole biosynthetic process BP
GO:0052838 thiazole metabolic process BP
GO:0071704 organic substance metabolic process BP
GO:0072527 pyrimidine-containing compound metabolic process BP
GO:0072528 pyrimidine-containing compound biosynthetic process BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1901362 organic cyclic compound biosynthetic process BP
GO:1901564 organonitrogen compound metabolic process BP
GO:1901566 organonitrogen compound biosynthetic process BP
GO:1901576 organic substance biosynthetic process BP
KEGG Term Name Description
map01100 Metabolic pathways -
map00730 Thiamine metabolism -