Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
Ciclev10025661m.g.v1.0
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Position
scaffold_7:10822408-10828538 (+)
6130bp
Gene Type
gene
Gene Description (Protein Product)
Lys-63-specific deubiquitinase
Organism
Citrus clementina
Also AS AT1G80210CICLE_v10025661mg

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
Ciclev10028313m.g.v1.0 26S proteasome non-atpase regulatory subunit
Ciclev10033395m.g.v1.0 component of the eukaryotic translation initiation factor 3 (eIF-3) complex; which is involved in protein synthesis of a specialized repertoire of mRNAs and; together with other initiation factors; stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation
Ciclev10025868m.g.v1.0 ubiquitin receptor

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000075 cell cycle checkpoint signaling BP
GO:0000077 DNA damage checkpoint signaling BP
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0004843 cysteine-type deubiquitinase activity MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006281 DNA repair BP
GO:0006282 regulation of DNA repair BP
GO:0006302 double-strand break repair BP
GO:0006325 chromatin organization BP
GO:0006464 protein modification process BP
GO:0006508 proteolysis BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0006996 organelle organization BP
GO:0007154 cell communication BP
GO:0007165 signal transduction BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008233 peptidase activity MF
GO:0008234 cysteine-type peptidase activity MF
GO:0008237 metallopeptidase activity MF
GO:0009314 response to radiation BP
GO:0009628 response to abiotic stimulus BP
GO:0009893 positive regulation of metabolic process BP
GO:0009987 cellular process BP
GO:0010212 response to ionizing radiation BP
GO:0010564 regulation of cell cycle process BP
GO:0010604 positive regulation of macromolecule metabolic process BP
GO:0010948 negative regulation of cell cycle process BP
GO:0016043 cellular component organization BP
GO:0016569 obsolete covalent chromatin modification BP
GO:0016570 histone modification BP
GO:0016578 histone deubiquitination BP
GO:0016579 protein deubiquitination BP
GO:0016787 hydrolase activity MF
GO:0019219 regulation of nucleobase-containing compound metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019538 protein metabolic process BP
GO:0019783 ubiquitin-like protein peptidase activity MF
GO:0023052 signaling BP
GO:0031323 regulation of cellular metabolic process BP
GO:0031325 positive regulation of cellular metabolic process BP
GO:0031570 DNA integrity checkpoint signaling BP
GO:0031572 mitotic G2 DNA damage checkpoint signaling BP
GO:0031593 polyubiquitin modification-dependent protein binding MF
GO:0032991 protein-containing complex CC
GO:0033554 cellular response to stress BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0035556 intracellular signal transduction BP
GO:0036211 protein modification process BP
GO:0036459 cysteine-type deubiquitinase activity MF
GO:0042770 signal transduction in response to DNA damage BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043412 macromolecule modification BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044267 protein metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0045739 positive regulation of DNA repair BP
GO:0045786 negative regulation of cell cycle BP
GO:0045935 positive regulation of nucleobase-containing compound metabolic process BP
GO:0046483 heterocycle metabolic process BP
GO:0048518 positive regulation of biological process BP
GO:0048519 negative regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0048523 negative regulation of cellular process BP
GO:0048583 regulation of response to stimulus BP
GO:0048584 positive regulation of response to stimulus BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051052 regulation of DNA metabolic process BP
GO:0051054 positive regulation of DNA metabolic process BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051173 positive regulation of nitrogen compound metabolic process BP
GO:0051276 chromosome organization BP
GO:0051716 cellular response to stimulus BP
GO:0051726 regulation of cell cycle BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0065007 biological regulation BP
GO:0070011 peptidase activity MF
GO:0070531 BRCA1-A complex CC
GO:0070536 protein K63-linked deubiquitination BP
GO:0070537 histone H2A K63-linked deubiquitination BP
GO:0070552 BRISC complex CC
GO:0070646 protein modification by small protein removal BP
GO:0070647 protein modification by small protein conjugation or removal BP
GO:0071704 organic substance metabolic process BP
GO:0071840 cellular component organization or biogenesis BP
GO:0072395 cell cycle checkpoint signaling BP
GO:0072401 DNA integrity checkpoint signaling BP
GO:0072422 DNA damage checkpoint signaling BP
GO:0072425 mitotic G2 DNA damage checkpoint signaling BP
GO:0080090 regulation of primary metabolic process BP
GO:0080134 regulation of response to stress BP
GO:0080135 regulation of cellular response to stress BP
GO:0090304 nucleic acid metabolic process BP
GO:0101005 deubiquitinase activity MF
GO:0140030 modification-dependent protein binding MF
GO:0140096 catalytic activity, acting on a protein MF
GO:1901360 organic cyclic compound metabolic process BP
GO:1901564 organonitrogen compound metabolic process BP
GO:1901987 regulation of cell cycle phase transition BP
GO:1901988 negative regulation of cell cycle phase transition BP
GO:1902749 regulation of cell cycle G2/M phase transition BP
GO:1902750 negative regulation of cell cycle G2/M phase transition BP
GO:2001020 regulation of response to DNA damage stimulus BP
GO:2001022 positive regulation of response to DNA damage stimulus BP
KEGG Term Name Description
map03440 Homologous recombination Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.