Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0003674 | molecular_function | MF |
| GO:0003824 | catalytic activity | MF |
| GO:0005215 | transporter activity | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005829 | cytosol | CC |
| GO:0005905 | clathrin-coated pit | CC |
| GO:0006810 | transport | BP |
| GO:0006897 | endocytosis | BP |
| GO:0008150 | biological_process | BP |
| GO:0009987 | cellular process | BP |
| GO:0012505 | endomembrane system | CC |
| GO:0012506 | vesicle membrane | CC |
| GO:0015399 | primary active transmembrane transporter activity | MF |
| GO:0015405 | ATPase-coupled transmembrane transporter activity | MF |
| GO:0016020 | membrane | CC |
| GO:0016043 | cellular component organization | BP |
| GO:0016192 | vesicle-mediated transport | BP |
| GO:0016462 | pyrophosphatase activity | MF |
| GO:0016787 | hydrolase activity | MF |
| GO:0016817 | hydrolase activity, acting on acid anhydrides | MF |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | MF |
| GO:0016887 | ATP hydrolysis activity | MF |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | MF |
| GO:0022804 | active transmembrane transporter activity | MF |
| GO:0022857 | transmembrane transporter activity | MF |
| GO:0030117 | membrane coat | CC |
| GO:0030118 | clathrin coat | CC |
| GO:0030120 | vesicle coat | CC |
| GO:0030125 | clathrin vesicle coat | CC |
| GO:0030135 | coated vesicle | CC |
| GO:0030136 | clathrin-coated vesicle | CC |
| GO:0030659 | cytoplasmic vesicle membrane | CC |
| GO:0030662 | coated vesicle membrane | CC |
| GO:0030665 | clathrin-coated vesicle membrane | CC |
| GO:0031090 | organelle membrane | CC |
| GO:0031410 | cytoplasmic vesicle | CC |
| GO:0031982 | vesicle | CC |
| GO:0032991 | protein-containing complex | CC |
| GO:0042623 | ATP hydrolysis activity | MF |
| GO:0042626 | ATPase-coupled transmembrane transporter activity | MF |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043492 | ATPase-coupled transmembrane transporter activity | MF |
| GO:0044422 | obsolete organelle part | CC |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044425 | obsolete membrane part | CC |
| GO:0044433 | obsolete cytoplasmic vesicle part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044446 | obsolete intracellular organelle part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0048475 | coated membrane | CC |
| GO:0051179 | localization | BP |
| GO:0051234 | establishment of localization | BP |
| GO:0055085 | transmembrane transport | BP |
| GO:0061024 | membrane organization | BP |
| GO:0071840 | cellular component organization or biogenesis | BP |
| GO:0097708 | intracellular vesicle | CC |
| GO:0098588 | bounding membrane of organelle | CC |
| GO:0098657 | import into cell | BP |
| GO:0098796 | membrane protein complex | CC |
| GO:0098805 | membrane | CC |
| KEGG Term | Name | Description |
|---|---|---|
| map04141 | Protein processing in endoplasmic reticulum | The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. |
| map04120 | Ubiquitin mediated proteolysis | Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. |