Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
JhiChr01G12500.g
View in Genome Browser
Position
chr1:22400032-22400285 (+)
253bp
Gene Type
gene
Gene Description (Protein Product)
DNA repair protein RAD50
Organism
Juglans hindsii
Also AS AT2G31970

Gene Structure

upstream:
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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
JhiChr11G12565.g Double-strand break repair protein
JhiChr06G11762.g Serine threonine-protein kinase
JhiChr01G12702.g ATP-dependent DNA helicase 2 subunit
Regulatory gene
JhiChr01G10819.g dof zinc finger protein
JhiChr01G11697.g dof zinc finger protein
JhiChr01G12868.g Dof zinc finger protein

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000003 reproduction BP
GO:0000228 nuclear chromosome CC
GO:0000280 nuclear division BP
GO:0000722 telomere maintenance via recombination BP
GO:0000723 telomere maintenance BP
GO:0000724 double-strand break repair via homologous recombination BP
GO:0000725 recombinational repair BP
GO:0000781 chromosome, telomeric region CC
GO:0000784 chromosome, telomeric region CC
GO:0000785 chromatin CC
GO:0000790 chromatin CC
GO:0000793 condensed chromosome CC
GO:0000794 condensed nuclear chromosome CC
GO:0003674 molecular_function MF
GO:0003676 nucleic acid binding MF
GO:0003677 DNA binding MF
GO:0003690 double-stranded DNA binding MF
GO:0003691 double-stranded telomeric DNA binding MF
GO:0003697 single-stranded DNA binding MF
GO:0003824 catalytic activity MF
GO:0004017 adenylate kinase activity MF
GO:0005488 binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005694 chromosome CC
GO:0005737 cytoplasm CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006278 RNA-templated DNA biosynthetic process BP
GO:0006281 DNA repair BP
GO:0006302 double-strand break repair BP
GO:0006310 DNA recombination BP
GO:0006312 mitotic recombination BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006753 nucleoside phosphate metabolic process BP
GO:0006793 phosphorus metabolic process BP
GO:0006796 phosphate-containing compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0006996 organelle organization BP
GO:0007004 telomere maintenance via telomerase BP
GO:0007049 cell cycle BP
GO:0007127 meiosis I BP
GO:0007131 reciprocal meiotic recombination BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009117 nucleotide metabolic process BP
GO:0009123 nucleoside monophosphate metabolic process BP
GO:0009165 nucleotide biosynthetic process BP
GO:0009987 cellular process BP
GO:0010833 telomere maintenance via telomere lengthening BP
GO:0016043 cellular component organization BP
GO:0016233 telomere capping BP
GO:0016301 kinase activity MF
GO:0016310 phosphorylation BP
GO:0016740 transferase activity MF
GO:0016772 transferase activity, transferring phosphorus-containing groups MF
GO:0016776 phosphotransferase activity, phosphate group as acceptor MF
GO:0018130 heterocycle biosynthetic process BP
GO:0019205 nucleobase-containing compound kinase activity MF
GO:0019438 aromatic compound biosynthetic process BP
GO:0019637 organophosphate metabolic process BP
GO:0022402 cell cycle process BP
GO:0022414 reproductive process BP
GO:0030870 Mre11 complex CC
GO:0031974 membrane-enclosed lumen CC
GO:0031981 nuclear lumen CC
GO:0032200 telomere organization BP
GO:0032392 DNA geometric change BP
GO:0032508 DNA duplex unwinding BP
GO:0032991 protein-containing complex CC
GO:0033554 cellular response to stress BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0034654 nucleobase-containing compound biosynthetic process BP
GO:0035825 homologous recombination BP
GO:0035861 site of double-strand break CC
GO:0042162 telomeric DNA binding MF
GO:0042592 homeostatic process BP
GO:0043047 single-stranded telomeric DNA binding MF
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0043565 sequence-specific DNA binding MF
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044271 cellular nitrogen compound biosynthetic process BP
GO:0044281 small molecule metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044427 obsolete chromosomal part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044454 obsolete nuclear chromosome part CC
GO:0044464 obsolete cell part CC
GO:0046483 heterocycle metabolic process BP
GO:0046940 nucleoside monophosphate phosphorylation BP
GO:0048285 organelle fission BP
GO:0050145 nucleoside monophosphate kinase activity MF
GO:0050896 response to stimulus BP
GO:0051276 chromosome organization BP
GO:0051321 meiotic cell cycle BP
GO:0051716 cellular response to stimulus BP
GO:0051880 G-quadruplex DNA binding MF
GO:0055086 nucleobase-containing small molecule metabolic process BP
GO:0060249 anatomical structure homeostasis BP
GO:0061982 meiosis I cell cycle process BP
GO:0065007 biological regulation BP
GO:0065008 regulation of biological quality BP
GO:0070013 intracellular organelle lumen CC
GO:0070192 chromosome organization involved in meiotic cell cycle BP
GO:0071103 DNA conformation change BP
GO:0071704 organic substance metabolic process BP
GO:0071840 cellular component organization or biogenesis BP
GO:0071897 DNA biosynthetic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0090305 nucleic acid phosphodiester bond hydrolysis BP
GO:0090407 organophosphate biosynthetic process BP
GO:0090734 site of DNA damage CC
GO:0097159 organic cyclic compound binding MF
GO:0098687 chromosomal region CC
GO:0098847 sequence-specific single stranded DNA binding MF
GO:0140013 meiotic nuclear division BP
GO:1901293 nucleoside phosphate biosynthetic process BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1901362 organic cyclic compound biosynthetic process BP
GO:1901363 heterocyclic compound binding MF
GO:1901576 organic substance biosynthetic process BP
GO:1903046 meiotic cell cycle process BP
KEGG Term Name Description
map03450 Non-homologous end-joining Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
map03440 Homologous recombination Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.