Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
JhiChr15G11966.g
View in Genome Browser
Position
chr15:30267234-30271007 (-)
3773bp
Gene Type
gene
Gene Description (Protein Product)
Participates in DNA repair and in chromosomal DNA replication
Organism
Juglans hindsii
Also AS AT5G22110

Gene Structure

upstream:
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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
JhiChr15G12200.g Belongs to the MCM family
JhiChr16G10112.g Replication factor C subunit
JhiChr16G11323.g CDK-activating kinase assembly factor MAT1
Regulatory gene
JhiChr05G10706.g Protein BASIC PENTACYSTEINE4-like
JhiChr06G10857.g Protein BASIC PENTACYSTEINE2-like
JhiChr06G10933.g Protein BASIC PENTACYSTEINE6-like

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000003 reproduction BP
GO:0000228 nuclear chromosome CC
GO:0000731 DNA synthesis involved in DNA repair BP
GO:0003006 developmental process involved in reproduction BP
GO:0003674 molecular_function MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005694 chromosome CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006260 DNA replication BP
GO:0006261 DNA-templated DNA replication BP
GO:0006281 DNA repair BP
GO:0006301 postreplication repair BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0007275 multicellular organism development BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008622 epsilon DNA polymerase complex CC
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009790 embryo development BP
GO:0009791 post-embryonic development BP
GO:0009793 embryo development ending in seed dormancy BP
GO:0009987 cellular process BP
GO:0010154 fruit development BP
GO:0018130 heterocycle biosynthetic process BP
GO:0019438 aromatic compound biosynthetic process BP
GO:0019899 enzyme binding MF
GO:0019985 translesion synthesis BP
GO:0022414 reproductive process BP
GO:0031974 membrane-enclosed lumen CC
GO:0031981 nuclear lumen CC
GO:0032501 multicellular organismal process BP
GO:0032502 developmental process BP
GO:0032991 protein-containing complex CC
GO:0033554 cellular response to stress BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0034654 nucleobase-containing compound biosynthetic process BP
GO:0042276 error-prone translesion synthesis BP
GO:0042575 DNA polymerase complex CC
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044271 cellular nitrogen compound biosynthetic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044427 obsolete chromosomal part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044454 obsolete nuclear chromosome part CC
GO:0044464 obsolete cell part CC
GO:0046483 heterocycle metabolic process BP
GO:0048316 seed development BP
GO:0048518 positive regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0048608 reproductive structure development BP
GO:0048731 system development BP
GO:0048856 anatomical structure development BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051302 regulation of cell division BP
GO:0051716 cellular response to stimulus BP
GO:0051781 positive regulation of cell division BP
GO:0061458 reproductive system development BP
GO:0061695 transferase complex, transferring phosphorus-containing groups CC
GO:0065007 biological regulation BP
GO:0070013 intracellular organelle lumen CC
GO:0070182 DNA polymerase binding MF
GO:0071704 organic substance metabolic process BP
GO:0071897 DNA biosynthetic process BP
GO:0090304 nucleic acid metabolic process BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1901362 organic cyclic compound biosynthetic process BP
GO:1901576 organic substance biosynthetic process BP
GO:1902494 catalytic complex CC
GO:1990234 transferase complex CC
KEGG Term Name Description
map03420 Nucleotide excision repair Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
map03410 Base excision repair Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
map03030 DNA replication A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.