Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0000268 | peroxisome targeting sequence binding | MF |
| GO:0003674 | molecular_function | MF |
| GO:0005048 | signal sequence binding | MF |
| GO:0005052 | peroxisome matrix targeting signal-1 binding | MF |
| GO:0005488 | binding | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005777 | peroxisome | CC |
| GO:0005778 | peroxisomal membrane | CC |
| GO:0005829 | cytosol | CC |
| GO:0006605 | protein targeting | BP |
| GO:0006625 | protein targeting to peroxisome | BP |
| GO:0006810 | transport | BP |
| GO:0006886 | intracellular protein transport | BP |
| GO:0006996 | organelle organization | BP |
| GO:0007031 | peroxisome organization | BP |
| GO:0008104 | protein localization | BP |
| GO:0008150 | biological_process | BP |
| GO:0009719 | response to endogenous stimulus | BP |
| GO:0009725 | response to hormone | BP |
| GO:0009733 | response to auxin | BP |
| GO:0009987 | cellular process | BP |
| GO:0010033 | response to organic substance | BP |
| GO:0015031 | protein transport | BP |
| GO:0015833 | peptide transport | BP |
| GO:0015919 | peroxisomal membrane transport | BP |
| GO:0016020 | membrane | CC |
| GO:0016043 | cellular component organization | BP |
| GO:0016558 | protein import into peroxisome matrix | BP |
| GO:0016560 | protein import into peroxisome matrix, docking | BP |
| GO:0017038 | protein import | BP |
| GO:0031090 | organelle membrane | CC |
| GO:0031903 | microbody membrane | CC |
| GO:0033036 | macromolecule localization | BP |
| GO:0033218 | amide binding | MF |
| GO:0033365 | protein localization to organelle | BP |
| GO:0034613 | protein localization | BP |
| GO:0042221 | response to chemical | BP |
| GO:0042277 | peptide binding | MF |
| GO:0042579 | microbody | CC |
| GO:0042886 | amide transport | BP |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043231 | intracellular membrane-bounded organelle | CC |
| GO:0043574 | peroxisomal transport | BP |
| GO:0044422 | obsolete organelle part | CC |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044438 | obsolete microbody part | CC |
| GO:0044439 | obsolete peroxisomal part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044446 | obsolete intracellular organelle part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0044743 | protein transmembrane import into intracellular organelle | BP |
| GO:0045184 | establishment of protein localization | BP |
| GO:0046907 | intracellular transport | BP |
| GO:0050896 | response to stimulus | BP |
| GO:0051179 | localization | BP |
| GO:0051234 | establishment of localization | BP |
| GO:0051641 | cellular localization | BP |
| GO:0051649 | establishment of localization in cell | BP |
| GO:0055085 | transmembrane transport | BP |
| GO:0065002 | intracellular protein transmembrane transport | BP |
| GO:0070727 | cellular macromolecule localization | BP |
| GO:0071702 | organic substance transport | BP |
| GO:0071705 | nitrogen compound transport | BP |
| GO:0071806 | protein transmembrane transport | BP |
| GO:0071840 | cellular component organization or biogenesis | BP |
| GO:0072594 | establishment of protein localization to organelle | BP |
| GO:0072662 | protein localization to peroxisome | BP |
| GO:0072663 | establishment of protein localization to peroxisome | BP |
| GO:0098588 | bounding membrane of organelle | CC |
| GO:0098805 | membrane | CC |
| KEGG Term | Name | Description |
|---|---|---|
| map04146 | Peroxisome | Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies. |

