Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0000217 | DNA secondary structure binding | MF |
| GO:0000404 | heteroduplex DNA loop binding | MF |
| GO:0003674 | molecular_function | MF |
| GO:0003676 | nucleic acid binding | MF |
| GO:0003677 | DNA binding | MF |
| GO:0003684 | damaged DNA binding | MF |
| GO:0003690 | double-stranded DNA binding | MF |
| GO:0003824 | catalytic activity | MF |
| GO:0005488 | binding | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0006139 | nucleobase-containing compound metabolic process | BP |
| GO:0006259 | DNA metabolic process | BP |
| GO:0006281 | DNA repair | BP |
| GO:0006298 | mismatch repair | BP |
| GO:0006725 | cellular aromatic compound metabolic process | BP |
| GO:0006807 | nitrogen compound metabolic process | BP |
| GO:0006950 | response to stress | BP |
| GO:0006974 | cellular response to DNA damage stimulus | BP |
| GO:0006996 | organelle organization | BP |
| GO:0008094 | ATP-dependent activity, acting on DNA | MF |
| GO:0008150 | biological_process | BP |
| GO:0008152 | metabolic process | BP |
| GO:0009987 | cellular process | BP |
| GO:0016043 | cellular component organization | BP |
| GO:0016462 | pyrophosphatase activity | MF |
| GO:0016787 | hydrolase activity | MF |
| GO:0016817 | hydrolase activity, acting on acid anhydrides | MF |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | MF |
| GO:0016887 | ATP hydrolysis activity | MF |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | MF |
| GO:0030983 | mismatched DNA binding | MF |
| GO:0032135 | DNA insertion or deletion binding | MF |
| GO:0032300 | mismatch repair complex | CC |
| GO:0032991 | protein-containing complex | CC |
| GO:0033554 | cellular response to stress | BP |
| GO:0034641 | cellular nitrogen compound metabolic process | BP |
| GO:0042623 | ATP hydrolysis activity | MF |
| GO:0043170 | macromolecule metabolic process | BP |
| GO:0043570 | maintenance of DNA repeat elements | BP |
| GO:0044237 | cellular metabolic process | BP |
| GO:0044238 | primary metabolic process | BP |
| GO:0044260 | cellular macromolecule metabolic process | BP |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0046483 | heterocycle metabolic process | BP |
| GO:0050896 | response to stimulus | BP |
| GO:0051276 | chromosome organization | BP |
| GO:0051716 | cellular response to stimulus | BP |
| GO:0071704 | organic substance metabolic process | BP |
| GO:0071840 | cellular component organization or biogenesis | BP |
| GO:0090304 | nucleic acid metabolic process | BP |
| GO:0097159 | organic cyclic compound binding | MF |
| GO:1901360 | organic cyclic compound metabolic process | BP |
| GO:1901363 | heterocyclic compound binding | MF |
| GO:1990391 | DNA repair complex | CC |
| KEGG Term | Name | Description |
|---|---|---|
| map03430 | Mismatch repair | DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems. |

