Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0003674 | molecular_function | MF |
| GO:0005488 | binding | MF |
| GO:0005515 | protein binding | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005634 | nucleus | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005829 | cytosol | CC |
| GO:0006508 | proteolysis | BP |
| GO:0006511 | ubiquitin-dependent protein catabolic process | BP |
| GO:0006807 | nitrogen compound metabolic process | BP |
| GO:0008150 | biological_process | BP |
| GO:0008152 | metabolic process | BP |
| GO:0009056 | catabolic process | BP |
| GO:0009057 | macromolecule catabolic process | BP |
| GO:0009987 | cellular process | BP |
| GO:0019538 | protein metabolic process | BP |
| GO:0019899 | enzyme binding | MF |
| GO:0019941 | modification-dependent protein catabolic process | BP |
| GO:0030163 | protein catabolic process | BP |
| GO:0031625 | ubiquitin protein ligase binding | MF |
| GO:0032182 | ubiquitin-like protein binding | MF |
| GO:0043130 | ubiquitin binding | MF |
| GO:0043170 | macromolecule metabolic process | BP |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043231 | intracellular membrane-bounded organelle | CC |
| GO:0043632 | modification-dependent macromolecule catabolic process | BP |
| GO:0044237 | cellular metabolic process | BP |
| GO:0044238 | primary metabolic process | BP |
| GO:0044248 | cellular catabolic process | BP |
| GO:0044257 | protein catabolic process | BP |
| GO:0044260 | cellular macromolecule metabolic process | BP |
| GO:0044265 | cellular macromolecule catabolic process | BP |
| GO:0044267 | protein metabolic process | BP |
| GO:0044389 | ubiquitin-like protein ligase binding | MF |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0051603 | proteolysis involved in protein catabolic process | BP |
| GO:0071704 | organic substance metabolic process | BP |
| GO:1901564 | organonitrogen compound metabolic process | BP |
| GO:1901565 | organonitrogen compound catabolic process | BP |
| GO:1901575 | organic substance catabolic process | BP |
| KEGG Term | Name | Description |
|---|---|---|
| map04141 | Protein processing in endoplasmic reticulum | The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. |

