Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Expresssion
Pathway
Basic Information
Gene ID
MD15G1036000.v1.1
View in Genome Browser
Position
Chr15:2520533-2526485 (+)
5952bp
Gene Type
gene
Gene Description (Protein Product)
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome
Organism
Malus domestica
Also AS MD15G1036000AT1G80260

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
MD15G1297700.v1.1 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair; ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator
MD17G1274500.v1.1 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair; ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator
MD17G1049700.v1.1 Tubulin is the major constituent of microtubules. It binds two moles of GTP; one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
Go Pathway
GO Term Description GO Category
GO:0001932 regulation of protein phosphorylation BP
GO:0001934 positive regulation of protein phosphorylation BP
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0004672 protein kinase activity MF
GO:0004674 protein serine/threonine kinase activity MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005737 cytoplasm CC
GO:0005938 cell cortex CC
GO:0006464 protein modification process BP
GO:0006468 protein phosphorylation BP
GO:0006793 phosphorus metabolic process BP
GO:0006796 phosphate-containing compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0007154 cell communication BP
GO:0007165 signal transduction BP
GO:0007346 regulation of mitotic cell cycle BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009653 anatomical structure morphogenesis BP
GO:0009893 positive regulation of metabolic process BP
GO:0009987 cellular process BP
GO:0010562 positive regulation of phosphorus metabolic process BP
GO:0010604 positive regulation of macromolecule metabolic process BP
GO:0016301 kinase activity MF
GO:0016310 phosphorylation BP
GO:0016740 transferase activity MF
GO:0016772 transferase activity, transferring phosphorus-containing groups MF
GO:0016773 phosphotransferase activity, alcohol group as acceptor MF
GO:0019220 regulation of phosphate metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019538 protein metabolic process BP
GO:0023014 signal transduction BP
GO:0023052 signaling BP
GO:0030587 sorocarp development BP
GO:0031098 stress-activated protein kinase signaling cascade BP
GO:0031323 regulation of cellular metabolic process BP
GO:0031325 positive regulation of cellular metabolic process BP
GO:0031399 regulation of protein modification process BP
GO:0031401 positive regulation of protein modification process BP
GO:0032147 activation of protein kinase activity BP
GO:0032268 regulation of protein metabolic process BP
GO:0032270 positive regulation of protein metabolic process BP
GO:0032502 developmental process BP
GO:0033554 cellular response to stress BP
GO:0033674 positive regulation of kinase activity BP
GO:0035556 intracellular signal transduction BP
GO:0036211 protein modification process BP
GO:0042325 regulation of phosphorylation BP
GO:0042327 positive regulation of phosphorylation BP
GO:0043085 positive regulation of catalytic activity BP
GO:0043170 macromolecule metabolic process BP
GO:0043412 macromolecule modification BP
GO:0043549 regulation of kinase activity BP
GO:0044093 positive regulation of molecular function BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044267 protein metabolic process BP
GO:0044424 obsolete intracellular part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044464 obsolete cell part CC
GO:0045859 regulation of protein kinase activity BP
GO:0045860 positive regulation of protein kinase activity BP
GO:0045937 positive regulation of phosphate metabolic process BP
GO:0048518 positive regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0048856 anatomical structure development BP
GO:0050789 regulation of biological process BP
GO:0050790 regulation of catalytic activity BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051173 positive regulation of nitrogen compound metabolic process BP
GO:0051174 regulation of phosphorus metabolic process BP
GO:0051246 regulation of protein metabolic process BP
GO:0051247 positive regulation of protein metabolic process BP
GO:0051338 regulation of transferase activity BP
GO:0051347 positive regulation of transferase activity BP
GO:0051703 biological process involved in intraspecies interaction between organisms BP
GO:0051704 obsolete multi-organism process BP
GO:0051716 cellular response to stimulus BP
GO:0051726 regulation of cell cycle BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0065007 biological regulation BP
GO:0065009 regulation of molecular function BP
GO:0071704 organic substance metabolic process BP
GO:0071944 cell periphery CC
GO:0080090 regulation of primary metabolic process BP
GO:0090702 socially cooperative development BP
GO:0099120 socially cooperative development BP
GO:0099568 cytoplasmic region CC
GO:0140096 catalytic activity, acting on a protein MF
GO:1901564 organonitrogen compound metabolic process BP