Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Expresssion
Pathway
Basic Information
Gene ID
MD15G1400900.v1.1
View in Genome Browser
Position
Chr15:50187639-50188501 (+)
862bp
Gene Type
gene
Gene Description (Protein Product)
establishment of protein localization to peroxisome
Organism
Malus domestica
Also AS MD15G1400900AT5G08470

Gene Structure

upstream:
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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
MD16G1187100.v1.1 Belongs to the mitochondrial carrier (TC 2.A.29) family
MD17G1189500.v1.1 Peroxisome biogenesis protein
MD17G1178300.v1.1 Belongs to the SNF7 family

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000003 reproduction BP
GO:0000166 nucleotide binding MF
GO:0001881 receptor recycling BP
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005524 ATP binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005737 cytoplasm CC
GO:0005777 peroxisome CC
GO:0005778 peroxisomal membrane CC
GO:0005829 cytosol CC
GO:0006082 organic acid metabolic process BP
GO:0006605 protein targeting BP
GO:0006625 protein targeting to peroxisome BP
GO:0006629 lipid metabolic process BP
GO:0006631 fatty acid metabolic process BP
GO:0006635 fatty acid beta-oxidation BP
GO:0006810 transport BP
GO:0006886 intracellular protein transport BP
GO:0006996 organelle organization BP
GO:0007017 microtubule-based process BP
GO:0007031 peroxisome organization BP
GO:0007275 multicellular organism development BP
GO:0007276 gamete generation BP
GO:0007283 spermatogenesis BP
GO:0007399 nervous system development BP
GO:0007417 central nervous system development BP
GO:0007422 peripheral nervous system development BP
GO:0008022 obsolete protein C-terminus binding MF
GO:0008104 protein localization BP
GO:0008144 obsolete drug binding MF
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009056 catabolic process BP
GO:0009062 fatty acid catabolic process BP
GO:0009987 cellular process BP
GO:0010001 glial cell differentiation BP
GO:0015031 protein transport BP
GO:0015833 peptide transport BP
GO:0015919 peroxisomal membrane transport BP
GO:0016020 membrane CC
GO:0016042 lipid catabolic process BP
GO:0016043 cellular component organization BP
GO:0016054 organic acid catabolic process BP
GO:0016462 pyrophosphatase activity MF
GO:0016558 protein import into peroxisome matrix BP
GO:0016562 protein import into peroxisome matrix, receptor recycling BP
GO:0016787 hydrolase activity MF
GO:0016817 hydrolase activity, acting on acid anhydrides MF
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides MF
GO:0016887 ATP hydrolysis activity MF
GO:0017038 protein import BP
GO:0017076 purine nucleotide binding MF
GO:0017111 ribonucleoside triphosphate phosphatase activity MF
GO:0019395 fatty acid oxidation BP
GO:0019752 carboxylic acid metabolic process BP
GO:0019953 sexual reproduction BP
GO:0021782 glial cell development BP
GO:0022008 neurogenesis BP
GO:0022412 cellular process involved in reproduction in multicellular organism BP
GO:0022414 reproductive process BP
GO:0023051 regulation of signaling BP
GO:0030154 cell differentiation BP
GO:0030258 lipid modification BP
GO:0030554 adenyl nucleotide binding MF
GO:0031090 organelle membrane CC
GO:0031903 microbody membrane CC
GO:0032501 multicellular organismal process BP
GO:0032502 developmental process BP
GO:0032504 multicellular organism reproduction BP
GO:0032553 ribonucleotide binding MF
GO:0032555 purine ribonucleotide binding MF
GO:0032559 adenyl ribonucleotide binding MF
GO:0032787 monocarboxylic acid metabolic process BP
GO:0033036 macromolecule localization BP
GO:0033365 protein localization to organelle BP
GO:0034440 lipid oxidation BP
GO:0034613 protein localization BP
GO:0035639 purine ribonucleoside triphosphate binding MF
GO:0036094 small molecule binding MF
GO:0042063 gliogenesis BP
GO:0042579 microbody CC
GO:0042623 ATP hydrolysis activity MF
GO:0042886 amide transport BP
GO:0043112 receptor metabolic process BP
GO:0043167 ion binding MF
GO:0043168 anion binding MF
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043436 oxoacid metabolic process BP
GO:0043574 peroxisomal transport BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044242 cellular lipid catabolic process BP
GO:0044248 cellular catabolic process BP
GO:0044255 cellular lipid metabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044281 small molecule metabolic process BP
GO:0044282 small molecule catabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044438 obsolete microbody part CC
GO:0044439 obsolete peroxisomal part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0044703 multi-organism reproductive process BP
GO:0044743 protein transmembrane import into intracellular organelle BP
GO:0044877 protein-containing complex binding MF
GO:0045184 establishment of protein localization BP
GO:0046395 carboxylic acid catabolic process BP
GO:0046907 intracellular transport BP
GO:0046982 protein heterodimerization activity MF
GO:0046983 protein dimerization activity MF
GO:0048137 spermatocyte division BP
GO:0048232 male gamete generation BP
GO:0048468 cell development BP
GO:0048609 multicellular organismal reproductive process BP
GO:0048731 system development BP
GO:0048856 anatomical structure development BP
GO:0048869 cellular developmental process BP
GO:0050789 regulation of biological process BP
GO:0051179 localization BP
GO:0051234 establishment of localization BP
GO:0051301 cell division BP
GO:0051640 organelle localization BP
GO:0051641 cellular localization BP
GO:0051649 establishment of localization in cell BP
GO:0051704 obsolete multi-organism process BP
GO:0055085 transmembrane transport BP
GO:0055114 obsolete oxidation-reduction process BP
GO:0060151 peroxisome localization BP
GO:0060152 microtubule-based peroxisome localization BP
GO:0065002 intracellular protein transmembrane transport BP
GO:0065007 biological regulation BP
GO:0070727 cellular macromolecule localization BP
GO:0071702 organic substance transport BP
GO:0071704 organic substance metabolic process BP
GO:0071705 nitrogen compound transport BP
GO:0071806 protein transmembrane transport BP
GO:0071840 cellular component organization or biogenesis BP
GO:0072329 monocarboxylic acid catabolic process BP
GO:0072594 establishment of protein localization to organelle BP
GO:0072662 protein localization to peroxisome BP
GO:0072663 establishment of protein localization to peroxisome BP
GO:0097159 organic cyclic compound binding MF
GO:0097367 carbohydrate derivative binding MF
GO:0098588 bounding membrane of organelle CC
GO:0098805 membrane CC
GO:1901265 nucleoside phosphate binding MF
GO:1901363 heterocyclic compound binding MF
GO:1901575 organic substance catabolic process BP
KEGG Term Name Description
map04146 Peroxisome Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
map04144 Endocytosis Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.