Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Expresssion
Pathway
Basic Information
Gene ID
MD17G1050400.v1.1
View in Genome Browser
Position
Chr17:3734328-3738004 (-)
3676bp
Gene Type
gene
Gene Description (Protein Product)
Belongs to the nucleosome assembly protein (NAP) family
Organism
Malus domestica
Also AS MD17G1050400AT1G18800

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
MD17G1145200.v1.1 GPN-loop GTPase 3 homolog
MD17G1211600.v1.1 Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family
MD17G1274500.v1.1 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair; ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
Go Pathway
GO Term Description GO Category
GO:0003674 molecular_function MF
GO:0004857 enzyme inhibitor activity MF
GO:0004864 protein phosphatase inhibitor activity MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005654 nucleoplasm CC
GO:0005737 cytoplasm CC
GO:0005783 endoplasmic reticulum CC
GO:0005811 lipid droplet CC
GO:0005829 cytosol CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006260 DNA replication BP
GO:0006323 chromosome organization BP
GO:0006325 chromatin organization BP
GO:0006333 chromatin organization BP
GO:0006334 nucleosome assembly BP
GO:0006337 nucleosome disassembly BP
GO:0006355 regulation of DNA-templated transcription BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006996 organelle organization BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009889 regulation of biosynthetic process BP
GO:0009890 negative regulation of biosynthetic process BP
GO:0009892 negative regulation of metabolic process BP
GO:0009894 regulation of catabolic process BP
GO:0009987 cellular process BP
GO:0010468 regulation of gene expression BP
GO:0010556 regulation of macromolecule biosynthetic process BP
GO:0010558 negative regulation of macromolecule biosynthetic process BP
GO:0010563 negative regulation of phosphorus metabolic process BP
GO:0010605 negative regulation of macromolecule metabolic process BP
GO:0010608 post-transcriptional regulation of gene expression BP
GO:0010629 negative regulation of gene expression BP
GO:0010639 negative regulation of organelle organization BP
GO:0010921 regulation of phosphatase activity BP
GO:0010923 negative regulation of phosphatase activity BP
GO:0010941 regulation of cell death BP
GO:0012505 endomembrane system CC
GO:0016043 cellular component organization BP
GO:0019208 phosphatase regulator activity MF
GO:0019212 phosphatase inhibitor activity MF
GO:0019219 regulation of nucleobase-containing compound metabolic process BP
GO:0019220 regulation of phosphate metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019888 protein phosphatase regulator activity MF
GO:0022411 cellular component disassembly BP
GO:0022607 cellular component assembly BP
GO:0030234 enzyme regulator activity MF
GO:0031056 regulation of histone modification BP
GO:0031057 negative regulation of histone modification BP
GO:0031323 regulation of cellular metabolic process BP
GO:0031324 negative regulation of cellular metabolic process BP
GO:0031326 regulation of cellular biosynthetic process BP
GO:0031327 negative regulation of cellular biosynthetic process BP
GO:0031329 regulation of cellular catabolic process BP
GO:0031399 regulation of protein modification process BP
GO:0031400 negative regulation of protein modification process BP
GO:0031497 chromatin organization BP
GO:0031498 obsolete chromatin disassembly BP
GO:0031974 membrane-enclosed lumen CC
GO:0031981 nuclear lumen CC
GO:0032268 regulation of protein metabolic process BP
GO:0032269 negative regulation of protein metabolic process BP
GO:0032515 negative regulation of phosphoprotein phosphatase activity BP
GO:0032984 protein-containing complex disassembly BP
GO:0032986 protein-DNA complex disassembly BP
GO:0032991 protein-containing complex CC
GO:0033043 regulation of organelle organization BP
GO:0033044 regulation of chromosome organization BP
GO:0034622 protein-containing complex assembly BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0034728 nucleosome organization BP
GO:0035065 regulation of histone acetylation BP
GO:0035067 negative regulation of histone acetylation BP
GO:0035303 regulation of dephosphorylation BP
GO:0035304 regulation of protein dephosphorylation BP
GO:0035305 negative regulation of dephosphorylation BP
GO:0035308 negative regulation of protein dephosphorylation BP
GO:0042393 histone binding MF
GO:0042981 regulation of apoptotic process BP
GO:0043066 negative regulation of apoptotic process BP
GO:0043067 regulation of programmed cell death BP
GO:0043069 negative regulation of programmed cell death BP
GO:0043086 negative regulation of catalytic activity BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0043487 regulation of RNA stability BP
GO:0043488 regulation of mRNA stability BP
GO:0043523 regulation of neuron apoptotic process BP
GO:0043524 negative regulation of neuron apoptotic process BP
GO:0043666 regulation of phosphoprotein phosphatase activity BP
GO:0043933 protein-containing complex organization BP
GO:0044085 cellular component biogenesis BP
GO:0044092 negative regulation of molecular function BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044428 obsolete nuclear part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0045892 negative regulation of DNA-templated transcription BP
GO:0045934 negative regulation of nucleobase-containing compound metabolic process BP
GO:0045936 negative regulation of phosphate metabolic process BP
GO:0046483 heterocycle metabolic process BP
GO:0048471 perinuclear region of cytoplasm CC
GO:0048519 negative regulation of biological process BP
GO:0048523 negative regulation of cellular process BP
GO:0050789 regulation of biological process BP
GO:0050790 regulation of catalytic activity BP
GO:0050794 regulation of cellular process BP
GO:0051128 regulation of cellular component organization BP
GO:0051129 negative regulation of cellular component organization BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051172 negative regulation of nitrogen compound metabolic process BP
GO:0051174 regulation of phosphorus metabolic process BP
GO:0051246 regulation of protein metabolic process BP
GO:0051248 negative regulation of protein metabolic process BP
GO:0051252 regulation of RNA metabolic process BP
GO:0051253 negative regulation of RNA metabolic process BP
GO:0051276 chromosome organization BP
GO:0051336 regulation of hydrolase activity BP
GO:0051346 negative regulation of hydrolase activity BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0060548 negative regulation of cell death BP
GO:0061013 regulation of mRNA catabolic process BP
GO:0065003 protein-containing complex assembly BP
GO:0065004 protein-DNA complex assembly BP
GO:0065007 biological regulation BP
GO:0065008 regulation of biological quality BP
GO:0065009 regulation of molecular function BP
GO:0070013 intracellular organelle lumen CC
GO:0071103 DNA conformation change BP
GO:0071704 organic substance metabolic process BP
GO:0071824 protein-DNA complex subunit organization BP
GO:0071840 cellular component organization or biogenesis BP
GO:0080090 regulation of primary metabolic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0098772 molecular function regulator activity MF
GO:1901214 regulation of neuron death BP
GO:1901215 negative regulation of neuron death BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1901576 organic substance biosynthetic process BP
GO:1901983 regulation of protein acetylation BP
GO:1901984 negative regulation of protein acetylation BP
GO:1902275 regulation of chromatin organization BP
GO:1902679 negative regulation of RNA biosynthetic process BP
GO:1903311 regulation of mRNA metabolic process BP
GO:1903506 regulation of nucleic acid-templated transcription BP
GO:1903507 negative regulation of nucleic acid-templated transcription BP
GO:1905268 negative regulation of chromatin organization BP
GO:2000112 regulation of cellular macromolecule biosynthetic process BP
GO:2000113 negative regulation of cellular macromolecule biosynthetic process BP
GO:2000756 regulation of peptidyl-lysine acetylation BP
GO:2000757 negative regulation of peptidyl-lysine acetylation BP
GO:2001141 regulation of RNA biosynthetic process BP
GO:2001251 negative regulation of chromosome organization BP