Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Expresssion
Pathway
Basic Information
Gene ID
MD17G1235800.v1.1
View in Genome Browser
Position
Chr17:28470661-28475516 (+)
4855bp
Gene Type
gene
Gene Description (Protein Product)
Cell cycle regulated microtubule associated protein
Organism
Malus domestica
Also AS MD17G1235800AT1G03780

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
MD17G1268900.v1.1 Condensin complex subunit
MD17G1236100.v1.1 checkpoint serine threonine-protein kinase
MD17G1274500.v1.1 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair; ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
Go Pathway
GO Term Description GO Category
GO:0000226 microtubule cytoskeleton organization BP
GO:0000278 mitotic cell cycle BP
GO:0000280 nuclear division BP
GO:0003674 molecular_function MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005654 nucleoplasm CC
GO:0005737 cytoplasm CC
GO:0005819 spindle CC
GO:0005856 cytoskeleton CC
GO:0005874 microtubule CC
GO:0006996 organelle organization BP
GO:0007010 cytoskeleton organization BP
GO:0007017 microtubule-based process BP
GO:0007049 cell cycle BP
GO:0007051 spindle organization BP
GO:0007052 mitotic spindle organization BP
GO:0007346 regulation of mitotic cell cycle BP
GO:0008017 microtubule binding MF
GO:0008092 cytoskeletal protein binding MF
GO:0008150 biological_process BP
GO:0009507 chloroplast CC
GO:0009524 phragmoplast CC
GO:0009526 plastid envelope CC
GO:0009536 plastid CC
GO:0009941 chloroplast envelope CC
GO:0009987 cellular process BP
GO:0010564 regulation of cell cycle process BP
GO:0015630 microtubule cytoskeleton CC
GO:0015631 tubulin binding MF
GO:0016043 cellular component organization BP
GO:0022402 cell cycle process BP
GO:0022607 cellular component assembly BP
GO:0031967 organelle envelope CC
GO:0031974 membrane-enclosed lumen CC
GO:0031975 envelope CC
GO:0031981 nuclear lumen CC
GO:0032886 regulation of microtubule-based process BP
GO:0033043 regulation of organelle organization BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0044085 cellular component biogenesis BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044428 obsolete nuclear part CC
GO:0044430 obsolete cytoskeletal part CC
GO:0044434 obsolete chloroplast part CC
GO:0044435 obsolete plastid part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0048285 organelle fission BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0051128 regulation of cellular component organization BP
GO:0051225 spindle assembly BP
GO:0051493 regulation of cytoskeleton organization BP
GO:0051726 regulation of cell cycle BP
GO:0060236 regulation of mitotic spindle organization BP
GO:0065007 biological regulation BP
GO:0070013 intracellular organelle lumen CC
GO:0070507 regulation of microtubule cytoskeleton organization BP
GO:0070925 organelle assembly BP
GO:0071840 cellular component organization or biogenesis BP
GO:0090224 regulation of spindle organization BP
GO:0090307 mitotic spindle assembly BP
GO:0099080 supramolecular complex CC
GO:0099081 supramolecular polymer CC
GO:0099512 supramolecular fiber CC
GO:0099513 polymeric cytoskeletal fiber CC
GO:0140014 mitotic nuclear division BP
GO:1902850 microtubule cytoskeleton organization involved in mitosis BP
GO:1903047 mitotic cell cycle process BP