Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0003674 | molecular_function | MF |
| GO:0003756 | protein disulfide isomerase activity | MF |
| GO:0003824 | catalytic activity | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005618 | cell wall | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005773 | vacuole | CC |
| GO:0005783 | endoplasmic reticulum | CC |
| GO:0005788 | endoplasmic reticulum lumen | CC |
| GO:0005794 | Golgi apparatus | CC |
| GO:0005886 | plasma membrane | CC |
| GO:0006457 | protein folding | BP |
| GO:0006950 | response to stress | BP |
| GO:0008150 | biological_process | BP |
| GO:0009505 | plant-type cell wall | CC |
| GO:0009987 | cellular process | BP |
| GO:0012505 | endomembrane system | CC |
| GO:0016020 | membrane | CC |
| GO:0016853 | isomerase activity | MF |
| GO:0016860 | intramolecular oxidoreductase activity | MF |
| GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | MF |
| GO:0030312 | external encapsulating structure | CC |
| GO:0031974 | membrane-enclosed lumen | CC |
| GO:0033554 | cellular response to stress | BP |
| GO:0034976 | response to endoplasmic reticulum stress | BP |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043231 | intracellular membrane-bounded organelle | CC |
| GO:0043233 | organelle lumen | CC |
| GO:0044422 | obsolete organelle part | CC |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044432 | obsolete endoplasmic reticulum part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044446 | obsolete intracellular organelle part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0050896 | response to stimulus | BP |
| GO:0051716 | cellular response to stimulus | BP |
| GO:0070013 | intracellular organelle lumen | CC |
| GO:0071944 | cell periphery | CC |
| GO:0140096 | catalytic activity, acting on a protein | MF |
| KEGG Term | Name | Description |
|---|---|---|
| map04141 | Protein processing in endoplasmic reticulum | The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. |