Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005886 | plasma membrane | CC |
| GO:0005905 | clathrin-coated pit | CC |
| GO:0012505 | endomembrane system | CC |
| GO:0012506 | vesicle membrane | CC |
| GO:0016020 | membrane | CC |
| GO:0030117 | membrane coat | CC |
| GO:0030118 | clathrin coat | CC |
| GO:0030119 | AP-type membrane coat adaptor complex | CC |
| GO:0030120 | vesicle coat | CC |
| GO:0030122 | AP-2 adaptor complex | CC |
| GO:0030125 | clathrin vesicle coat | CC |
| GO:0030128 | clathrin coat of endocytic vesicle | CC |
| GO:0030131 | clathrin adaptor complex | CC |
| GO:0030132 | clathrin coat of coated pit | CC |
| GO:0030135 | coated vesicle | CC |
| GO:0030136 | clathrin-coated vesicle | CC |
| GO:0030139 | endocytic vesicle | CC |
| GO:0030659 | cytoplasmic vesicle membrane | CC |
| GO:0030662 | coated vesicle membrane | CC |
| GO:0030665 | clathrin-coated vesicle membrane | CC |
| GO:0030666 | endocytic vesicle membrane | CC |
| GO:0030669 | clathrin-coated endocytic vesicle membrane | CC |
| GO:0031090 | organelle membrane | CC |
| GO:0031201 | SNARE complex | CC |
| GO:0031410 | cytoplasmic vesicle | CC |
| GO:0031982 | vesicle | CC |
| GO:0032991 | protein-containing complex | CC |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0044422 | obsolete organelle part | CC |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044425 | obsolete membrane part | CC |
| GO:0044433 | obsolete cytoplasmic vesicle part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044446 | obsolete intracellular organelle part | CC |
| GO:0044459 | obsolete plasma membrane part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0045334 | clathrin-coated endocytic vesicle | CC |
| GO:0048475 | coated membrane | CC |
| GO:0071944 | cell periphery | CC |
| GO:0097708 | intracellular vesicle | CC |
| GO:0098588 | bounding membrane of organelle | CC |
| GO:0098796 | membrane protein complex | CC |
| GO:0098797 | plasma membrane protein complex | CC |
| GO:0098805 | membrane | CC |
| KEGG Term | Name | Description |
|---|---|---|
| map04144 | Endocytosis | Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. |

