Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005634 | nucleus | CC |
| GO:0005654 | nucleoplasm | CC |
| GO:0005730 | nucleolus | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005794 | Golgi apparatus | CC |
| GO:0005829 | cytosol | CC |
| GO:0005886 | plasma membrane | CC |
| GO:0008150 | biological_process | BP |
| GO:0009893 | positive regulation of metabolic process | BP |
| GO:0009894 | regulation of catabolic process | BP |
| GO:0009896 | positive regulation of catabolic process | BP |
| GO:0010035 | response to inorganic substance | BP |
| GO:0010038 | response to metal ion | BP |
| GO:0010604 | positive regulation of macromolecule metabolic process | BP |
| GO:0012505 | endomembrane system | CC |
| GO:0016020 | membrane | CC |
| GO:0019222 | regulation of metabolic process | BP |
| GO:0031974 | membrane-enclosed lumen | CC |
| GO:0031981 | nuclear lumen | CC |
| GO:0042176 | regulation of protein catabolic process | BP |
| GO:0042221 | response to chemical | BP |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043228 | non-membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043231 | intracellular membrane-bounded organelle | CC |
| GO:0043232 | intracellular non-membrane-bounded organelle | CC |
| GO:0043233 | organelle lumen | CC |
| GO:0044422 | obsolete organelle part | CC |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044428 | obsolete nuclear part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044446 | obsolete intracellular organelle part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0045732 | positive regulation of protein catabolic process | BP |
| GO:0046686 | response to cadmium ion | BP |
| GO:0048518 | positive regulation of biological process | BP |
| GO:0050789 | regulation of biological process | BP |
| GO:0050896 | response to stimulus | BP |
| GO:0051171 | regulation of nitrogen compound metabolic process | BP |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | BP |
| GO:0051246 | regulation of protein metabolic process | BP |
| GO:0051247 | positive regulation of protein metabolic process | BP |
| GO:0060255 | regulation of macromolecule metabolic process | BP |
| GO:0065007 | biological regulation | BP |
| GO:0070013 | intracellular organelle lumen | CC |
| GO:0071944 | cell periphery | CC |
| GO:0080090 | regulation of primary metabolic process | BP |
| KEGG Term | Name | Description |
|---|---|---|
| map04141 | Protein processing in endoplasmic reticulum | The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. |