PPGR - Gene Detail

Basic Information

Gene Structure

Domain

Regulation&
Interaction

Annotation

Orthologus Group

Expresssion

Pathway

Basic Information

Gene ID	gene-LOC118054149 View in Genome Browser
Position	NW_023271550.1:74626-76574 (+) 1948bp
Gene Type	gene
Gene Description (Protein Product)	26S proteasome regulatory subunit
Organism	Populus alba
Also AS	Potri.006G078800AT2G26590Potri.006G078800.v4.1

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)	gene-LOC118058803 26S proteasome non-atpase regulatory subunit gene-LOC118054970 Belongs to the AAA ATPase family gene-LOC118061152 Belongs to the AAA ATPase family
Regulatory gene	gene-LOC118027806 Cyclic dof factor gene-LOC118028026 Telomere repeat-binding protein gene-LOC118028055 Dof zinc finger protein

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Expression Profile

DataSet	Number of Samples expressed(TPM>1)	Mean	Min	Max	Standard deviation(SD)	Coeffcient variation(CV)

Select Expression

Pathway

GO Term	Description	GO Category
GO:0000502	proteasome complex	CC
GO:0003674	molecular_function	MF
GO:0005488	binding	MF
GO:0005515	protein binding	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005838	proteasome regulatory particle	CC
GO:0006508	proteolysis	BP
GO:0006511	ubiquitin-dependent protein catabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0008047	enzyme activator activity	MF
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0008541	proteasome regulatory particle, lid subcomplex	CC
GO:0009056	catabolic process	BP
GO:0009057	macromolecule catabolic process	BP
GO:0009893	positive regulation of metabolic process	BP
GO:0009987	cellular process	BP
GO:0010604	positive regulation of macromolecule metabolic process	BP
GO:0010950	positive regulation of endopeptidase activity	BP
GO:0010952	positive regulation of peptidase activity	BP
GO:0016043	cellular component organization	BP
GO:0016504	peptidase activator activity	MF
GO:0019222	regulation of metabolic process	BP
GO:0019538	protein metabolic process	BP
GO:0019941	modification-dependent protein catabolic process	BP
GO:0022607	cellular component assembly	BP
GO:0022624	proteasome accessory complex	CC
GO:0030162	regulation of proteolysis	BP
GO:0030163	protein catabolic process	BP
GO:0030234	enzyme regulator activity	MF
GO:0031323	regulation of cellular metabolic process	BP
GO:0031325	positive regulation of cellular metabolic process	BP
GO:0032182	ubiquitin-like protein binding	MF
GO:0032268	regulation of protein metabolic process	BP
GO:0032270	positive regulation of protein metabolic process	BP
GO:0032991	protein-containing complex	CC
GO:0034622	protein-containing complex assembly	BP
GO:0043085	positive regulation of catalytic activity	BP
GO:0043130	ubiquitin binding	MF
GO:0043170	macromolecule metabolic process	BP
GO:0043248	proteasome assembly	BP
GO:0043632	modification-dependent macromolecule catabolic process	BP
GO:0043933	protein-containing complex organization	BP
GO:0044085	cellular component biogenesis	BP
GO:0044093	positive regulation of molecular function	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044248	cellular catabolic process	BP
GO:0044257	protein catabolic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044265	cellular macromolecule catabolic process	BP
GO:0044267	protein metabolic process	BP
GO:0044424	obsolete intracellular part	CC
GO:0044464	obsolete cell part	CC
GO:0044877	protein-containing complex binding	MF
GO:0045862	positive regulation of proteolysis	BP
GO:0048518	positive regulation of biological process	BP
GO:0048522	positive regulation of cellular process	BP
GO:0050789	regulation of biological process	BP
GO:0050790	regulation of catalytic activity	BP
GO:0050794	regulation of cellular process	BP
GO:0051171	regulation of nitrogen compound metabolic process	BP
GO:0051173	positive regulation of nitrogen compound metabolic process	BP
GO:0051246	regulation of protein metabolic process	BP
GO:0051247	positive regulation of protein metabolic process	BP
GO:0051336	regulation of hydrolase activity	BP
GO:0051345	positive regulation of hydrolase activity	BP
GO:0051603	proteolysis involved in protein catabolic process	BP
GO:0052547	regulation of peptidase activity	BP
GO:0052548	regulation of endopeptidase activity	BP
GO:0060255	regulation of macromolecule metabolic process	BP
GO:0061133	endopeptidase activator activity	MF
GO:0061134	peptidase regulator activity	MF
GO:0061135	endopeptidase regulator activity	MF
GO:0065003	protein-containing complex assembly	BP
GO:0065007	biological regulation	BP
GO:0065009	regulation of molecular function	BP
GO:0070628	proteasome binding	MF
GO:0071704	organic substance metabolic process	BP
GO:0071840	cellular component organization or biogenesis	BP
GO:0080090	regulation of primary metabolic process	BP
GO:0098772	molecular function regulator activity	MF
GO:1901564	organonitrogen compound metabolic process	BP
GO:1901565	organonitrogen compound catabolic process	BP
GO:1901575	organic substance catabolic process	BP
GO:1902494	catalytic complex	CC
GO:1905368	peptidase complex	CC
GO:1905369	endopeptidase complex	CC

KEGG Term	Name	Description
map03050	Proteasome	The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.