Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
gene-POTOM_062196
View in Genome Browser
Position
JAAWWB010002340.1:16058-19640 (-)
3582bp
Gene Type
gene
Gene Description (Protein Product)
"BRCA2
Organism
Populus tomentosa
Also AS Potri.014G189600AT5G01630Potri.014G189600.v4.1

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
gene-POTOM_062217 DNA topoisomerase 2-binding protein

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000003 reproduction BP
GO:0000226 microtubule cytoskeleton organization BP
GO:0000228 nuclear chromosome CC
GO:0000278 mitotic cell cycle BP
GO:0000280 nuclear division BP
GO:0000281 mitotic cytokinesis BP
GO:0000722 telomere maintenance via recombination BP
GO:0000723 telomere maintenance BP
GO:0000724 double-strand break repair via homologous recombination BP
GO:0000725 recombinational repair BP
GO:0000781 chromosome, telomeric region CC
GO:0000784 chromosome, telomeric region CC
GO:0000793 condensed chromosome CC
GO:0000794 condensed nuclear chromosome CC
GO:0000795 synaptonemal complex CC
GO:0000800 lateral element CC
GO:0000910 cytokinesis BP
GO:0001556 oocyte maturation BP
GO:0001701 in utero embryonic development BP
GO:0001824 blastocyst development BP
GO:0001832 blastocyst growth BP
GO:0001833 inner cell mass cell proliferation BP
GO:0002020 protease binding MF
GO:0002376 immune system process BP
GO:0002520 immune system development BP
GO:0003006 developmental process involved in reproduction BP
GO:0003674 molecular_function MF
GO:0003676 nucleic acid binding MF
GO:0003677 DNA binding MF
GO:0003697 single-stranded DNA binding MF
GO:0003824 catalytic activity MF
GO:0004402 histone acetyltransferase activity MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005654 nucleoplasm CC
GO:0005694 chromosome CC
GO:0005737 cytoplasm CC
GO:0005739 mitochondrion CC
GO:0005813 centrosome CC
GO:0005815 microtubule organizing center CC
GO:0005829 cytosol CC
GO:0005856 cytoskeleton CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006260 DNA replication BP
GO:0006261 DNA-templated DNA replication BP
GO:0006275 regulation of DNA replication BP
GO:0006281 DNA repair BP
GO:0006289 nucleotide-excision repair BP
GO:0006302 double-strand break repair BP
GO:0006310 DNA recombination BP
GO:0006312 mitotic recombination BP
GO:0006325 chromatin organization BP
GO:0006355 regulation of DNA-templated transcription BP
GO:0006464 protein modification process BP
GO:0006473 protein acetylation BP
GO:0006475 internal protein amino acid acetylation BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006915 apoptotic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator BP
GO:0006996 organelle organization BP
GO:0007010 cytoskeleton organization BP
GO:0007017 microtubule-based process BP
GO:0007049 cell cycle BP
GO:0007059 chromosome segregation BP
GO:0007098 centrosome cycle BP
GO:0007127 meiosis I BP
GO:0007140 male meiotic nuclear division BP
GO:0007141 male meiosis I BP
GO:0007154 cell communication BP
GO:0007165 signal transduction BP
GO:0007275 multicellular organism development BP
GO:0007276 gamete generation BP
GO:0007281 germ cell development BP
GO:0007283 spermatogenesis BP
GO:0007292 female gamete generation BP
GO:0007346 regulation of mitotic cell cycle BP
GO:0007399 nervous system development BP
GO:0007417 central nervous system development BP
GO:0007420 brain development BP
GO:0007548 sex differentiation BP
GO:0007568 aging BP
GO:0007569 obsolete cell aging BP
GO:0008022 obsolete protein C-terminus binding MF
GO:0008080 N-acetyltransferase activity MF
GO:0008092 cytoskeletal protein binding MF
GO:0008104 protein localization BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008156 negative regulation of DNA replication BP
GO:0008219 cell death BP
GO:0008283 cell population proliferation BP
GO:0008285 negative regulation of cell population proliferation BP
GO:0008406 gonad development BP
GO:0008585 female gonad development BP
GO:0008608 attachment of spindle microtubules to kinetochore BP
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage BP
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009314 response to radiation BP
GO:0009411 response to UV BP
GO:0009416 response to light stimulus BP
GO:0009628 response to abiotic stimulus BP
GO:0009790 embryo development BP
GO:0009792 embryo development ending in birth or egg hatching BP
GO:0009889 regulation of biosynthetic process BP
GO:0009890 negative regulation of biosynthetic process BP
GO:0009891 positive regulation of biosynthetic process BP
GO:0009892 negative regulation of metabolic process BP
GO:0009893 positive regulation of metabolic process BP
GO:0009987 cellular process BP
GO:0009994 oocyte differentiation BP
GO:0010165 response to X-ray BP
GO:0010212 response to ionizing radiation BP
GO:0010225 response to UV-C BP
GO:0010332 response to gamma radiation BP
GO:0010468 regulation of gene expression BP
GO:0010484 histone H3 acetyltransferase activity MF
GO:0010485 histone H4 acetyltransferase activity MF
GO:0010556 regulation of macromolecule biosynthetic process BP
GO:0010557 positive regulation of macromolecule biosynthetic process BP
GO:0010558 negative regulation of macromolecule biosynthetic process BP
GO:0010564 regulation of cell cycle process BP
GO:0010604 positive regulation of macromolecule metabolic process BP
GO:0010605 negative regulation of macromolecule metabolic process BP
GO:0010628 positive regulation of gene expression BP
GO:0012501 programmed cell death BP
GO:0012505 endomembrane system CC
GO:0015630 microtubule cytoskeleton CC
GO:0015631 tubulin binding MF
GO:0016043 cellular component organization BP
GO:0016407 acetyltransferase activity MF
GO:0016410 N-acyltransferase activity MF
GO:0016569 obsolete covalent chromatin modification BP
GO:0016570 histone modification BP
GO:0016573 histone acetylation BP
GO:0016740 transferase activity MF
GO:0016746 acyltransferase activity MF
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups MF
GO:0018193 peptidyl-amino acid modification BP
GO:0018205 peptidyl-lysine modification BP
GO:0018393 internal peptidyl-lysine acetylation BP
GO:0018394 peptidyl-lysine acetylation BP
GO:0019219 regulation of nucleobase-containing compound metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019538 protein metabolic process BP
GO:0019899 enzyme binding MF
GO:0019953 sexual reproduction BP
GO:0021700 developmental maturation BP
GO:0022402 cell cycle process BP
GO:0022412 cellular process involved in reproduction in multicellular organism BP
GO:0022414 reproductive process BP
GO:0023052 signaling BP
GO:0030097 hemopoiesis BP
GO:0030141 secretory granule CC
GO:0030154 cell differentiation BP
GO:0030330 DNA damage response, signal transduction by p53 class mediator BP
GO:0030879 mammary gland development BP
GO:0031023 microtubule organizing center organization BP
GO:0031297 replication fork processing BP
GO:0031323 regulation of cellular metabolic process BP
GO:0031324 negative regulation of cellular metabolic process BP
GO:0031325 positive regulation of cellular metabolic process BP
GO:0031326 regulation of cellular biosynthetic process BP
GO:0031327 negative regulation of cellular biosynthetic process BP
GO:0031328 positive regulation of cellular biosynthetic process BP
GO:0031410 cytoplasmic vesicle CC
GO:0031619 homologous chromosome orientation involved in meiotic metaphase I plate congression BP
GO:0031974 membrane-enclosed lumen CC
GO:0031981 nuclear lumen CC
GO:0031982 vesicle CC
GO:0032200 telomere organization BP
GO:0032465 regulation of cytokinesis BP
GO:0032501 multicellular organismal process BP
GO:0032502 developmental process BP
GO:0032504 multicellular organism reproduction BP
GO:0032991 protein-containing complex CC
GO:0033036 macromolecule localization BP
GO:0033260 nuclear DNA replication BP
GO:0033365 protein localization to organelle BP
GO:0033554 cellular response to stress BP
GO:0033593 BRCA2-MAGE-D1 complex CC
GO:0033599 regulation of mammary gland epithelial cell proliferation BP
GO:0033600 negative regulation of mammary gland epithelial cell proliferation BP
GO:0034212 peptide N-acetyltransferase activity MF
GO:0034502 protein localization to chromosome BP
GO:0034613 protein localization BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0035264 multicellular organism growth BP
GO:0035556 intracellular signal transduction BP
GO:0036211 protein modification process BP
GO:0040007 growth BP
GO:0042127 regulation of cell population proliferation BP
GO:0042592 homeostatic process BP
GO:0042770 signal transduction in response to DNA damage BP
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator BP
GO:0042772 DNA damage response, signal transduction resulting in transcription BP
GO:0042802 identical protein binding MF
GO:0043009 chordate embryonic development BP
GO:0043015 gamma-tubulin binding MF
GO:0043060 meiotic metaphase I plate congression BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0043412 macromolecule modification BP
GO:0043543 protein acylation BP
GO:0043966 histone H3 acetylation BP
GO:0043967 histone H4 acetylation BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044267 protein metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044427 obsolete chromosomal part CC
GO:0044428 obsolete nuclear part CC
GO:0044430 obsolete cytoskeletal part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044454 obsolete nuclear chromosome part CC
GO:0044464 obsolete cell part CC
GO:0044703 multi-organism reproductive process BP
GO:0044786 cell cycle DNA replication BP
GO:0045005 DNA-templated DNA replication maintenance of fidelity BP
GO:0045132 meiotic chromosome segregation BP
GO:0045137 development of primary sexual characteristics BP
GO:0045143 homologous chromosome segregation BP
GO:0045184 establishment of protein localization BP
GO:0045787 positive regulation of cell cycle BP
GO:0045893 positive regulation of DNA-templated transcription BP
GO:0045931 positive regulation of mitotic cell cycle BP
GO:0045934 negative regulation of nucleobase-containing compound metabolic process BP
GO:0045935 positive regulation of nucleobase-containing compound metabolic process BP
GO:0046483 heterocycle metabolic process BP
GO:0046545 development of primary female sexual characteristics BP
GO:0046660 female sex differentiation BP
GO:0048232 male gamete generation BP
GO:0048285 organelle fission BP
GO:0048468 cell development BP
GO:0048469 cell maturation BP
GO:0048477 oogenesis BP
GO:0048478 replication fork protection BP
GO:0048513 animal organ development BP
GO:0048518 positive regulation of biological process BP
GO:0048519 negative regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0048523 negative regulation of cellular process BP
GO:0048534 hematopoietic or lymphoid organ development BP
GO:0048589 developmental growth BP
GO:0048599 oocyte development BP
GO:0048608 reproductive structure development BP
GO:0048609 multicellular organismal reproductive process BP
GO:0048731 system development BP
GO:0048732 gland development BP
GO:0048856 anatomical structure development BP
GO:0048869 cellular developmental process BP
GO:0050000 chromosome localization BP
GO:0050678 regulation of epithelial cell proliferation BP
GO:0050680 negative regulation of epithelial cell proliferation BP
GO:0050789 regulation of biological process BP
GO:0050793 regulation of developmental process BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051052 regulation of DNA metabolic process BP
GO:0051053 negative regulation of DNA metabolic process BP
GO:0051093 negative regulation of developmental process BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051172 negative regulation of nitrogen compound metabolic process BP
GO:0051173 positive regulation of nitrogen compound metabolic process BP
GO:0051179 localization BP
GO:0051234 establishment of localization BP
GO:0051239 regulation of multicellular organismal process BP
GO:0051241 negative regulation of multicellular organismal process BP
GO:0051252 regulation of RNA metabolic process BP
GO:0051254 positive regulation of RNA metabolic process BP
GO:0051276 chromosome organization BP
GO:0051298 centrosome duplication BP
GO:0051301 cell division BP
GO:0051302 regulation of cell division BP
GO:0051303 establishment of chromosome localization BP
GO:0051310 metaphase plate congression BP
GO:0051311 meiotic metaphase plate congression BP
GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation BP
GO:0051321 meiotic cell cycle BP
GO:0051455 monopolar spindle attachment to meiosis I kinetochore BP
GO:0051640 organelle localization BP
GO:0051641 cellular localization BP
GO:0051649 establishment of localization in cell BP
GO:0051656 establishment of organelle localization BP
GO:0051704 obsolete multi-organism process BP
GO:0051716 cellular response to stimulus BP
GO:0051726 regulation of cell cycle BP
GO:0060249 anatomical structure homeostasis BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0060322 head development BP
GO:0061458 reproductive system development BP
GO:0061640 cytoskeleton-dependent cytokinesis BP
GO:0061733 peptide-lysine-N-acetyltransferase activity MF
GO:0061982 meiosis I cell cycle process BP
GO:0065007 biological regulation BP
GO:0065008 regulation of biological quality BP
GO:0070013 intracellular organelle lumen CC
GO:0070198 protein localization to chromosome, telomeric region BP
GO:0070199 establishment of protein localization to chromosome BP
GO:0070200 establishment of protein localization to telomere BP
GO:0070727 cellular macromolecule localization BP
GO:0071695 anatomical structure maturation BP
GO:0071704 organic substance metabolic process BP
GO:0071840 cellular component organization or biogenesis BP
GO:0072331 signal transduction by p53 class mediator BP
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator BP
GO:0072594 establishment of protein localization to organelle BP
GO:0080090 regulation of primary metabolic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0090329 regulation of DNA-templated DNA replication BP
GO:0097159 organic cyclic compound binding MF
GO:0097190 apoptotic signaling pathway BP
GO:0097193 intrinsic apoptotic signaling pathway BP
GO:0097708 intracellular vesicle CC
GO:0098687 chromosomal region CC
GO:0098813 nuclear chromosome segregation BP
GO:0099086 synaptonemal structure CC
GO:0099503 secretory vesicle CC
GO:0140013 meiotic nuclear division BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1901363 heterocyclic compound binding MF
GO:1901564 organonitrogen compound metabolic process BP
GO:1901576 organic substance biosynthetic process BP
GO:1902298 cell cycle DNA replication maintenance of fidelity BP
GO:1902680 positive regulation of RNA biosynthetic process BP
GO:1902969 mitotic DNA replication BP
GO:1903046 meiotic cell cycle process BP
GO:1903047 mitotic cell cycle process BP
GO:1903506 regulation of nucleic acid-templated transcription BP
GO:1903508 positive regulation of nucleic acid-templated transcription BP
GO:1990426 mitotic recombination-dependent replication fork processing BP
GO:1990505 mitotic DNA replication maintenance of fidelity BP
GO:2000026 regulation of multicellular organismal development BP
GO:2000104 negative regulation of DNA-templated DNA replication BP
GO:2000112 regulation of cellular macromolecule biosynthetic process BP
GO:2000113 negative regulation of cellular macromolecule biosynthetic process BP
GO:2001141 regulation of RNA biosynthetic process BP
KEGG Term Name Description
map03440 Homologous recombination Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.