PPGR - Gene Detail

Basic Information

Gene Structure

Domain

Regulation&
Interaction

Annotation

Orthologus Group

Pathway

Basic Information

Gene ID	Potra2n13c25363 View in Genome Browser
Position	chr13:3915288-3921319 (+) 6031bp
Gene Type	gene
Gene Description (Protein Product)	negative regulation of hemoglobin biosynthetic process Eukaryotic translation initiation factor 2-alpha kinase
Organism	Populus tremula
Also AS	Potri.007G128300AT3G59410Potri.007G128300.v4.1

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)	Potra2n8c17268 Eukaryotic translation initiation factor 2 Potra2n1c1434 Belongs to the eIF-2B alpha beta delta subunits family Potra2n3c7893 Belongs to the eIF-2B alpha beta delta subunits family
Regulatory gene	Potra2n10c20185 - Potra2n10c20485 Transcription factor Potra2n10c20596 Dof zinc finger protein

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Pathway

GO Term	Description	GO Category
GO:0001932	regulation of protein phosphorylation	BP
GO:0002376	immune system process	BP
GO:0002520	immune system development	BP
GO:0002521	leukocyte differentiation	BP
GO:0002526	acute inflammatory response	BP
GO:0002573	myeloid leukocyte differentiation	BP
GO:0003674	molecular_function	MF
GO:0003824	catalytic activity	MF
GO:0004672	protein kinase activity	MF
GO:0004674	protein serine/threonine kinase activity	MF
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	MF
GO:0005488	binding	MF
GO:0005515	protein binding	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005737	cytoplasm	CC
GO:0006417	regulation of translation	BP
GO:0006446	regulation of translational initiation	BP
GO:0006447	regulation of translational initiation by iron	BP
GO:0006464	protein modification process	BP
GO:0006468	protein phosphorylation	BP
GO:0006725	cellular aromatic compound metabolic process	BP
GO:0006778	porphyrin-containing compound metabolic process	BP
GO:0006793	phosphorus metabolic process	BP
GO:0006796	phosphate-containing compound metabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0006810	transport	BP
GO:0006897	endocytosis	BP
GO:0006909	phagocytosis	BP
GO:0006950	response to stress	BP
GO:0006952	defense response	BP
GO:0006954	inflammatory response	BP
GO:0007275	multicellular organism development	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0008285	negative regulation of cell population proliferation	BP
GO:0009605	response to external stimulus	BP
GO:0009889	regulation of biosynthetic process	BP
GO:0009890	negative regulation of biosynthetic process	BP
GO:0009892	negative regulation of metabolic process	BP
GO:0009987	cellular process	BP
GO:0009991	response to extracellular stimulus	BP
GO:0010468	regulation of gene expression	BP
GO:0010556	regulation of macromolecule biosynthetic process	BP
GO:0010558	negative regulation of macromolecule biosynthetic process	BP
GO:0010605	negative regulation of macromolecule metabolic process	BP
GO:0010608	post-transcriptional regulation of gene expression	BP
GO:0010629	negative regulation of gene expression	BP
GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	BP
GO:0010999	regulation of eIF2 alpha phosphorylation by heme	BP
GO:0016192	vesicle-mediated transport	BP
GO:0016301	kinase activity	MF
GO:0016310	phosphorylation	BP
GO:0016740	transferase activity	MF
GO:0016772	transferase activity, transferring phosphorus-containing groups	MF
GO:0016773	phosphotransferase activity, alcohol group as acceptor	MF
GO:0017148	negative regulation of translation	BP
GO:0018105	peptidyl-serine phosphorylation	BP
GO:0018193	peptidyl-amino acid modification	BP
GO:0018209	peptidyl-serine modification	BP
GO:0019220	regulation of phosphate metabolic process	BP
GO:0019222	regulation of metabolic process	BP
GO:0019538	protein metabolic process	BP
GO:0020037	heme binding	MF
GO:0030097	hemopoiesis	BP
GO:0030099	myeloid cell differentiation	BP
GO:0030154	cell differentiation	BP
GO:0030225	macrophage differentiation	BP
GO:0031323	regulation of cellular metabolic process	BP
GO:0031324	negative regulation of cellular metabolic process	BP
GO:0031326	regulation of cellular biosynthetic process	BP
GO:0031327	negative regulation of cellular biosynthetic process	BP
GO:0031399	regulation of protein modification process	BP
GO:0031667	response to nutrient levels	BP
GO:0032268	regulation of protein metabolic process	BP
GO:0032269	negative regulation of protein metabolic process	BP
GO:0032501	multicellular organismal process	BP
GO:0032502	developmental process	BP
GO:0033013	tetrapyrrole metabolic process	BP
GO:0033554	cellular response to stress	BP
GO:0034248	regulation of amide metabolic process	BP
GO:0034249	negative regulation of amide metabolic process	BP
GO:0036211	protein modification process	BP
GO:0042127	regulation of cell population proliferation	BP
GO:0042325	regulation of phosphorylation	BP
GO:0042592	homeostatic process	BP
GO:0042594	response to starvation	BP
GO:0042802	identical protein binding	MF
GO:0042803	protein homodimerization activity	MF
GO:0043170	macromolecule metabolic process	BP
GO:0043412	macromolecule modification	BP
GO:0043555	regulation of translation in response to stress	BP
GO:0043558	regulation of translational initiation in response to stress	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044267	protein metabolic process	BP
GO:0044424	obsolete intracellular part	CC
GO:0044464	obsolete cell part	CC
GO:0045182	translation regulator activity	MF
GO:0045947	negative regulation of translational initiation	BP
GO:0045993	negative regulation of translational initiation by iron	BP
GO:0046483	heterocycle metabolic process	BP
GO:0046501	protoporphyrinogen IX metabolic process	BP
GO:0046777	protein autophosphorylation	BP
GO:0046906	tetrapyrrole binding	MF
GO:0046983	protein dimerization activity	MF
GO:0046984	regulation of hemoglobin biosynthetic process	BP
GO:0046986	negative regulation of hemoglobin biosynthetic process	BP
GO:0048037	obsolete cofactor binding	MF
GO:0048513	animal organ development	BP
GO:0048519	negative regulation of biological process	BP
GO:0048523	negative regulation of cellular process	BP
GO:0048534	hematopoietic or lymphoid organ development	BP
GO:0048583	regulation of response to stimulus	BP
GO:0048731	system development	BP
GO:0048856	anatomical structure development	BP
GO:0048869	cellular developmental process	BP
GO:0048878	chemical homeostasis	BP
GO:0050789	regulation of biological process	BP
GO:0050794	regulation of cellular process	BP
GO:0050801	monoatomic ion homeostasis	BP
GO:0050896	response to stimulus	BP
GO:0051171	regulation of nitrogen compound metabolic process	BP
GO:0051172	negative regulation of nitrogen compound metabolic process	BP
GO:0051174	regulation of phosphorus metabolic process	BP
GO:0051179	localization	BP
GO:0051186	obsolete cofactor metabolic process	BP
GO:0051234	establishment of localization	BP
GO:0051246	regulation of protein metabolic process	BP
GO:0051248	negative regulation of protein metabolic process	BP
GO:0051716	cellular response to stimulus	BP
GO:0055065	obsolete metal ion homeostasis	BP
GO:0055072	iron ion homeostasis	BP
GO:0055076	obsolete transition metal ion homeostasis	BP
GO:0055080	monoatomic cation homeostasis	BP
GO:0060255	regulation of macromolecule metabolic process	BP
GO:0065007	biological regulation	BP
GO:0065008	regulation of biological quality	BP
GO:0071704	organic substance metabolic process	BP
GO:0080090	regulation of primary metabolic process	BP
GO:0080134	regulation of response to stress	BP
GO:0080135	regulation of cellular response to stress	BP
GO:0097159	organic cyclic compound binding	MF
GO:0098657	import into cell	BP
GO:0098771	inorganic ion homeostasis	BP
GO:0140096	catalytic activity, acting on a protein	MF
GO:1901360	organic cyclic compound metabolic process	BP
GO:1901363	heterocyclic compound binding	MF
GO:1901564	organonitrogen compound metabolic process	BP
GO:1990641	response to iron ion starvation	BP
GO:2000112	regulation of cellular macromolecule biosynthetic process	BP
GO:2000113	negative regulation of cellular macromolecule biosynthetic process	BP
GO:0000186	obsolete activation of MAPKK activity	BP
GO:0001817	regulation of cytokine production	BP
GO:0001819	positive regulation of cytokine production	BP
GO:0001934	positive regulation of protein phosphorylation	BP
GO:0002237	response to molecule of bacterial origin	BP
GO:0002682	regulation of immune system process	BP
GO:0003676	nucleic acid binding	MF
GO:0003723	RNA binding	MF
GO:0003725	double-stranded RNA binding	MF
GO:0005634	nucleus	CC
GO:0005829	cytosol	CC
GO:0005840	ribosome	CC
GO:0006355	regulation of DNA-templated transcription	BP
GO:0006412	translation	BP
GO:0006518	peptide metabolic process	BP
GO:0006986	response to unfolded protein	BP
GO:0007154	cell communication	BP
GO:0007165	signal transduction	BP
GO:0007584	response to nutrient	BP
GO:0009058	biosynthetic process	BP
GO:0009059	macromolecule biosynthetic process	BP
GO:0009267	cellular response to starvation	BP
GO:0009607	response to biotic stimulus	BP
GO:0009612	response to mechanical stimulus	BP
GO:0009615	response to virus	BP
GO:0009617	response to bacterium	BP
GO:0009628	response to abiotic stimulus	BP
GO:0009636	response to toxic substance	BP
GO:0009893	positive regulation of metabolic process	BP
GO:0009966	regulation of signal transduction	BP
GO:0009967	positive regulation of signal transduction	BP
GO:0010033	response to organic substance	BP
GO:0010467	gene expression	BP
GO:0010562	positive regulation of phosphorus metabolic process	BP
GO:0010604	positive regulation of macromolecule metabolic process	BP
GO:0010646	regulation of cell communication	BP
GO:0010647	positive regulation of cell communication	BP
GO:0010921	regulation of phosphatase activity	BP
GO:0010941	regulation of cell death	BP
GO:0010942	positive regulation of cell death	BP
GO:0014070	response to organic cyclic compound	BP
GO:0016032	viral process	BP
GO:0019048	modulation by virus of host process	BP
GO:0019049	mitigation of host antiviral defense response	BP
GO:0019208	phosphatase regulator activity	MF
GO:0019219	regulation of nucleobase-containing compound metabolic process	BP
GO:0019888	protein phosphatase regulator activity	MF
GO:0020012	evasion of host immune response	BP
GO:0023051	regulation of signaling	BP
GO:0023052	signaling	BP
GO:0023056	positive regulation of signaling	BP
GO:0030234	enzyme regulator activity	MF
GO:0030682	mitigation of host defenses by symbiont	BP
GO:0030683	mitigation of host antiviral defense response	BP
GO:0030968	endoplasmic reticulum unfolded protein response	BP
GO:0031325	positive regulation of cellular metabolic process	BP
GO:0031401	positive regulation of protein modification process	BP
GO:0031668	cellular response to extracellular stimulus	BP
GO:0031669	cellular response to nutrient levels	BP
GO:0032147	activation of protein kinase activity	BP
GO:0032270	positive regulation of protein metabolic process	BP
GO:0032496	response to lipopolysaccharide	BP
GO:0032642	regulation of chemokine production	BP
GO:0032722	positive regulation of chemokine production	BP
GO:0032872	regulation of stress-activated MAPK cascade	BP
GO:0032874	positive regulation of stress-activated MAPK cascade	BP
GO:0032991	protein-containing complex	CC
GO:0033197	response to vitamin E	BP
GO:0033273	response to vitamin	BP
GO:0033674	positive regulation of kinase activity	BP
GO:0033688	regulation of osteoblast proliferation	BP
GO:0033689	negative regulation of osteoblast proliferation	BP
GO:0033993	response to lipid	BP
GO:0034097	response to cytokine	BP
GO:0034198	cellular response to amino acid starvation	BP
GO:0034620	cellular response to unfolded protein	BP
GO:0034641	cellular nitrogen compound metabolic process	BP
GO:0034645	cellular macromolecule biosynthetic process	BP
GO:0034976	response to endoplasmic reticulum stress	BP
GO:0035303	regulation of dephosphorylation	BP
GO:0035304	regulation of protein dephosphorylation	BP
GO:0035455	response to interferon-alpha	BP
GO:0035821	modulation of process of another organism	BP
GO:0035966	response to topologically incorrect protein	BP
GO:0035967	cellular response to topologically incorrect protein	BP
GO:0042221	response to chemical	BP
GO:0042327	positive regulation of phosphorylation	BP
GO:0042981	regulation of apoptotic process	BP
GO:0043043	peptide biosynthetic process	BP
GO:0043065	positive regulation of apoptotic process	BP
GO:0043066	negative regulation of apoptotic process	BP
GO:0043067	regulation of programmed cell death	BP
GO:0043068	positive regulation of programmed cell death	BP
GO:0043069	negative regulation of programmed cell death	BP
GO:0043085	positive regulation of catalytic activity	BP
GO:0043207	response to external biotic stimulus	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043228	non-membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0043232	intracellular non-membrane-bounded organelle	CC
GO:0043254	regulation of protein-containing complex assembly	BP
GO:0043330	response to exogenous dsRNA	BP
GO:0043331	response to dsRNA	BP
GO:0043405	regulation of MAP kinase activity	BP
GO:0043406	positive regulation of MAP kinase activity	BP
GO:0043408	regulation of MAPK cascade	BP
GO:0043410	positive regulation of MAPK cascade	BP
GO:0043549	regulation of kinase activity	BP
GO:0043603	amide metabolic process	BP
GO:0043604	amide biosynthetic process	BP
GO:0043666	regulation of phosphoprotein phosphatase activity	BP
GO:0043900	obsolete regulation of multi-organism process	BP
GO:0043901	obsolete negative regulation of multi-organism process	BP
GO:0043903	regulation of biological process involved in symbiotic interaction	BP
GO:0044003	modulation by symbiont of host process	BP
GO:0044087	regulation of cellular component biogenesis	BP
GO:0044093	positive regulation of molecular function	BP
GO:0044249	cellular biosynthetic process	BP
GO:0044271	cellular nitrogen compound biosynthetic process	BP
GO:0044403	biological process involved in symbiotic interaction	BP
GO:0044413	mitigation of host defenses by symbiont	BP
GO:0044415	mitigation of host defenses by symbiont	BP
GO:0044419	biological process involved in interspecies interaction between organisms	BP
GO:0044444	obsolete cytoplasmic part	CC
GO:0045069	regulation of viral genome replication	BP
GO:0045071	negative regulation of viral genome replication	BP
GO:0045595	regulation of cell differentiation	BP
GO:0045859	regulation of protein kinase activity	BP
GO:0045860	positive regulation of protein kinase activity	BP
GO:0045937	positive regulation of phosphate metabolic process	BP
GO:0048471	perinuclear region of cytoplasm	CC
GO:0048518	positive regulation of biological process	BP
GO:0048522	positive regulation of cellular process	BP
GO:0048525	negative regulation of viral process	BP
GO:0048584	positive regulation of response to stimulus	BP
GO:0050690	mitigation of host antiviral defense response	BP
GO:0050790	regulation of catalytic activity	BP
GO:0050792	regulation of viral process	BP
GO:0050793	regulation of developmental process	BP
GO:0051090	regulation of DNA-binding transcription factor activity	BP
GO:0051091	positive regulation of DNA-binding transcription factor activity	BP
GO:0051092	positive regulation of NF-kappaB transcription factor activity	BP
GO:0051128	regulation of cellular component organization	BP
GO:0051173	positive regulation of nitrogen compound metabolic process	BP
GO:0051239	regulation of multicellular organismal process	BP
GO:0051240	positive regulation of multicellular organismal process	BP
GO:0051247	positive regulation of protein metabolic process	BP
GO:0051252	regulation of RNA metabolic process	BP
GO:0051336	regulation of hydrolase activity	BP
GO:0051338	regulation of transferase activity	BP
GO:0051347	positive regulation of transferase activity	BP
GO:0051701	biological process involved in interaction with host	BP
GO:0051704	obsolete multi-organism process	BP
GO:0051707	response to other organism	BP
GO:0051805	evasion of host immune response	BP
GO:0051807	mitigation of host defenses by symbiont	BP
GO:0051817	obsolete modulation of process of other organism involved in symbiotic interaction	BP
GO:0051832	mitigation of host defenses by symbiont	BP
GO:0051834	mitigation of host defenses by symbiont	BP
GO:0052173	response to defenses of other organism	BP
GO:0052200	response to host defenses	BP
GO:0052564	response to host immune response	BP
GO:0052572	response to host immune response	BP
GO:0060548	negative regulation of cell death	BP
GO:0065009	regulation of molecular function	BP
GO:0070302	regulation of stress-activated protein kinase signaling cascade	BP
GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	BP
GO:0070887	cellular response to chemical stimulus	BP
GO:0071310	cellular response to organic substance	BP
GO:0071496	cellular response to external stimulus	BP
GO:0071900	regulation of protein serine/threonine kinase activity	BP
GO:0071902	positive regulation of protein serine/threonine kinase activity	BP
GO:0072091	regulation of stem cell proliferation	BP
GO:0075136	response to host	BP
GO:0098772	molecular function regulator activity	MF
GO:1900225	regulation of NLRP3 inflammasome complex assembly	BP
GO:1901222	regulation of NIK/NF-kappaB signaling	BP
GO:1901224	positive regulation of NIK/NF-kappaB signaling	BP
GO:1901532	regulation of hematopoietic progenitor cell differentiation	BP
GO:1901566	organonitrogen compound biosynthetic process	BP
GO:1901576	organic substance biosynthetic process	BP
GO:1901698	response to nitrogen compound	BP
GO:1901700	response to oxygen-containing compound	BP
GO:1902033	regulation of hematopoietic stem cell proliferation	BP
GO:1902036	regulation of hematopoietic stem cell differentiation	BP
GO:1902531	regulation of intracellular signal transduction	BP
GO:1902533	positive regulation of intracellular signal transduction	BP
GO:1903506	regulation of nucleic acid-templated transcription	BP
GO:1903706	regulation of hemopoiesis	BP
GO:1903900	regulation of viral life cycle	BP
GO:1903901	negative regulation of viral life cycle	BP
GO:1990904	ribonucleoprotein complex	CC
GO:1990928	response to amino acid starvation	BP
GO:2000026	regulation of multicellular organismal development	BP
GO:2000736	regulation of stem cell differentiation	BP
GO:2001141	regulation of RNA biosynthetic process	BP

KEGG Term	Name	Description
map04141	Protein processing in endoplasmic reticulum	The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
map04141	Protein processing in endoplasmic reticulum	The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.