Basic Information
Gene Structure
upstream:
Get Sequence
Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0000502 | proteasome complex | CC |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005829 | cytosol | CC |
| GO:0005839 | proteasome core complex | CC |
| GO:0005886 | plasma membrane | CC |
| GO:0005911 | cell-cell junction | CC |
| GO:0006807 | nitrogen compound metabolic process | BP |
| GO:0008150 | biological_process | BP |
| GO:0008152 | metabolic process | BP |
| GO:0009056 | catabolic process | BP |
| GO:0009057 | macromolecule catabolic process | BP |
| GO:0009506 | plasmodesma | CC |
| GO:0016020 | membrane | CC |
| GO:0019538 | protein metabolic process | BP |
| GO:0019773 | proteasome core complex, alpha-subunit complex | CC |
| GO:0030054 | cell junction | CC |
| GO:0030163 | protein catabolic process | BP |
| GO:0032991 | protein-containing complex | CC |
| GO:0042221 | response to chemical | BP |
| GO:0043170 | macromolecule metabolic process | BP |
| GO:0044238 | primary metabolic process | BP |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0046685 | response to arsenic-containing substance | BP |
| GO:0050896 | response to stimulus | BP |
| GO:0055044 | symplast | CC |
| GO:0071704 | organic substance metabolic process | BP |
| GO:0071944 | cell periphery | CC |
| GO:1901564 | organonitrogen compound metabolic process | BP |
| GO:1901565 | organonitrogen compound catabolic process | BP |
| GO:1901575 | organic substance catabolic process | BP |
| GO:1902494 | catalytic complex | CC |
| GO:1905368 | peptidase complex | CC |
| GO:1905369 | endopeptidase complex | CC |
| KEGG Term | Name | Description |
|---|---|---|
| map03050 | Proteasome | The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides. |
| map01110 | Biosynthesis of secondary metabolites | - |
| map01100 | Metabolic pathways | - |