PPGR - Gene Detail

Basic Information

Gene ID	Potra2n8c18318 View in Genome Browser
Position	chr8:12353741-12362368 (-) 8627bp
Gene Type	gene
Gene Description (Protein Product)	Belongs to the actin family
Organism	Populus tremula
Also AS	Potri.008G182700AT1G13180Potri.008G182700.v4.1

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

Potra2n9c19560 Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

Potra2n9c19442 Belongs to the actin family

Potra2n9c18943 E3 ubiquitin-protein ligase

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Pathway

GO Term	Description	GO Category
GO:0000902	cell morphogenesis	BP
GO:0000904	cell morphogenesis involved in differentiation	BP
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005737	cytoplasm	CC
GO:0005829	cytosol	CC
GO:0005856	cytoskeleton	CC
GO:0005885	Arp2/3 protein complex	CC
GO:0006996	organelle organization	BP
GO:0007010	cytoskeleton organization	BP
GO:0007015	actin filament organization	BP
GO:0008150	biological_process	BP
GO:0009653	anatomical structure morphogenesis	BP
GO:0009825	multidimensional cell growth	BP
GO:0009888	tissue development	BP
GO:0009987	cellular process	BP
GO:0010026	trichome differentiation	BP
GO:0010090	trichome morphogenesis	BP
GO:0015629	actin cytoskeleton	CC
GO:0016043	cellular component organization	BP
GO:0016049	cell growth	BP
GO:0030029	actin filament-based process	BP
GO:0030036	actin cytoskeleton organization	BP
GO:0030154	cell differentiation	BP
GO:0032502	developmental process	BP
GO:0032989	cellular component morphogenesis	BP
GO:0032991	protein-containing complex	CC
GO:0040007	growth	BP
GO:0043226	organelle	CC
GO:0043228	non-membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043232	intracellular non-membrane-bounded organelle	CC
GO:0044422	obsolete organelle part	CC
GO:0044424	obsolete intracellular part	CC
GO:0044430	obsolete cytoskeletal part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044446	obsolete intracellular organelle part	CC
GO:0044464	obsolete cell part	CC
GO:0048468	cell development	BP
GO:0048856	anatomical structure development	BP
GO:0048869	cellular developmental process	BP
GO:0071840	cellular component organization or biogenesis	BP
GO:0090558	plant epidermis development	BP
GO:0090626	plant epidermis morphogenesis	BP
GO:0097435	supramolecular fiber organization	BP

KEGG Term	Name	Description
map04144	Endocytosis	Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
map03015	mRNA surveillance pathway	The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.