PPGR - Gene Detail

Gene ID	Potra2n9c19951 View in Genome Browser
Position	chr9:10150474-10154952 (-) 4478bp
Gene Type	gene
Gene Description (Protein Product)	"The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg
Organism	Populus tremula
Also AS	Potri.009G020800AT2G27020Potri.009G020800.v4.1

upstream:

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Protein-protein interaction (PPI)

Potra2n9c20077 Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function

Potra2n9c20036 Belongs to the chaperonin (HSP60) family

Potra2n9c20072 ZINC FINGER protein

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Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

GO Term	Description	GO Category
GO:0000502	proteasome complex	CC
GO:0005575	cellular_component	CC
GO:0005576	extracellular region	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005634	nucleus	CC
GO:0005737	cytoplasm	CC
GO:0005773	vacuole	CC
GO:0005774	vacuolar membrane	CC
GO:0005829	cytosol	CC
GO:0005839	proteasome core complex	CC
GO:0006950	response to stress	BP
GO:0008150	biological_process	BP
GO:0009266	response to temperature stimulus	BP
GO:0009409	response to cold	BP
GO:0009628	response to abiotic stimulus	BP
GO:0010035	response to inorganic substance	BP
GO:0010038	response to metal ion	BP
GO:0016020	membrane	CC
GO:0019773	proteasome core complex, alpha-subunit complex	CC
GO:0031090	organelle membrane	CC
GO:0032991	protein-containing complex	CC
GO:0042221	response to chemical	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0044422	obsolete organelle part	CC
GO:0044424	obsolete intracellular part	CC
GO:0044437	obsolete vacuolar part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044446	obsolete intracellular organelle part	CC
GO:0044464	obsolete cell part	CC
GO:0046686	response to cadmium ion	BP
GO:0048046	apoplast	CC
GO:0050896	response to stimulus	BP
GO:0098588	bounding membrane of organelle	CC
GO:0098805	membrane	CC
GO:1902494	catalytic complex	CC
GO:1905368	peptidase complex	CC
GO:1905369	endopeptidase complex	CC

KEGG Term	Name	Description
map03050	Proteasome	The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.