PPGR - Gene Detail

Basic Information

Gene ID	gene-LOC103956653 View in Genome Browser
Position	NW_025999413.1:1299550-1314214 (-) 14664bp
Gene Type	gene
Gene Description (Protein Product)	threonine-type endopeptidase activity
Organism	Pyrus x bretschneideri
Also AS	MD09G1024200AT5G47750

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

gene-LOC125474299 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg; Phe; Tyr; Leu; and Glu adjacent to the leaving group at neutral or slightly basic pH

gene-LOC103961487 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg; Phe; Tyr; Leu; and Glu adjacent to the leaving group at neutral or slightly basic pH

gene-LOC108867474 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg; Phe; Tyr; Leu; and Glu adjacent to the leaving group at neutral or slightly basic pH

Regulatory gene

gene-LOC103926579 transcription factor

gene-LOC103926580 Developmental protein SEPALLATA

gene-LOC103926616 ethylene-responsive transcription factor

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Expression Profile

DataSet	Number of Samples expressed(TPM>1)	Mean	Min	Max	Standard deviation(SD)	Coeffcient variation(CV)

Select Expression

Pathway

GO Term	Description	GO Category
GO:0000502	proteasome complex	CC
GO:0003674	molecular_function	MF
GO:0005488	binding	MF
GO:0005515	protein binding	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005634	nucleus	CC
GO:0005737	cytoplasm	CC
GO:0005739	mitochondrion	CC
GO:0005829	cytosol	CC
GO:0005839	proteasome core complex	CC
GO:0006508	proteolysis	BP
GO:0006511	ubiquitin-dependent protein catabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0009056	catabolic process	BP
GO:0009057	macromolecule catabolic process	BP
GO:0009987	cellular process	BP
GO:0010498	proteasomal protein catabolic process	BP
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	BP
GO:0012505	endomembrane system	CC
GO:0016020	membrane	CC
GO:0019538	protein metabolic process	BP
GO:0019773	proteasome core complex, alpha-subunit complex	CC
GO:0019941	modification-dependent protein catabolic process	BP
GO:0030163	protein catabolic process	BP
GO:0031597	cytosolic proteasome complex	CC
GO:0032991	protein-containing complex	CC
GO:0034515	proteasome storage granule	CC
GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	CC
GO:0042802	identical protein binding	MF
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	BP
GO:0043170	macromolecule metabolic process	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0043632	modification-dependent macromolecule catabolic process	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044248	cellular catabolic process	BP
GO:0044257	protein catabolic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044265	cellular macromolecule catabolic process	BP
GO:0044267	protein metabolic process	BP
GO:0044424	obsolete intracellular part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044445	obsolete cytosolic part	CC
GO:0044464	obsolete cell part	CC
GO:0051603	proteolysis involved in protein catabolic process	BP
GO:0071704	organic substance metabolic process	BP
GO:1901564	organonitrogen compound metabolic process	BP
GO:1901565	organonitrogen compound catabolic process	BP
GO:1901575	organic substance catabolic process	BP
GO:1902494	catalytic complex	CC
GO:1905368	peptidase complex	CC
GO:1905369	endopeptidase complex	CC

KEGG Term	Name	Description
map03050	Proteasome	The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.