PPGR - Gene Detail

Basic Information

Gene Structure

Domain

Regulation&
Interaction

Annotation

Orthologus Group

Expresssion

Pathway

Basic Information

Gene ID	QL12p001301.g View in Genome Browser
Position	chr12:1296438-1304756 (+) 8318bp
Gene Type	gene
Gene Description (Protein Product)	Dolichol phosphate-mannose biosynthesis regulatory
Organism	Quercus lobata
Also AS	AT1G74340

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)	QL12p004398.g Phosphatidylinositol-glycan biosynthesis class X QL12p027136.g Dol-P-Man Man(5)GlcNAc(2)-PP-Dol QL12p004876.g GWT1
Regulatory gene	QL01p032408.g Dof zinc finger protein QL01p036638.g dof zinc finger protein QL02p024902.g dof zinc finger protein

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Expression Profile

DataSet	Number of Samples expressed(TPM>1)	Mean	Min	Max	Standard deviation(SD)	Coeffcient variation(CV)

Select Expression

Pathway

GO Term	Description	GO Category
GO:0003674	molecular_function	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005737	cytoplasm	CC
GO:0005783	endoplasmic reticulum	CC
GO:0005789	endoplasmic reticulum membrane	CC
GO:0006066	alcohol metabolic process	BP
GO:0006464	protein modification process	BP
GO:0006486	protein glycosylation	BP
GO:0006493	protein O-linked glycosylation	BP
GO:0006497	protein lipidation	BP
GO:0006505	GPI anchor metabolic process	BP
GO:0006506	GPI anchor biosynthetic process	BP
GO:0006629	lipid metabolic process	BP
GO:0006643	membrane lipid metabolic process	BP
GO:0006644	phospholipid metabolic process	BP
GO:0006650	glycerophospholipid metabolic process	BP
GO:0006661	phosphatidylinositol biosynthetic process	BP
GO:0006664	glycolipid metabolic process	BP
GO:0006720	isoprenoid metabolic process	BP
GO:0006793	phosphorus metabolic process	BP
GO:0006796	phosphate-containing compound metabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0008610	lipid biosynthetic process	BP
GO:0008654	phospholipid biosynthetic process	BP
GO:0009058	biosynthetic process	BP
GO:0009059	macromolecule biosynthetic process	BP
GO:0009100	glycoprotein metabolic process	BP
GO:0009101	glycoprotein biosynthetic process	BP
GO:0009247	glycolipid biosynthetic process	BP
GO:0009987	cellular process	BP
GO:0012505	endomembrane system	CC
GO:0016020	membrane	CC
GO:0016093	polyprenol metabolic process	BP
GO:0019348	dolichol metabolic process	BP
GO:0019538	protein metabolic process	BP
GO:0019637	organophosphate metabolic process	BP
GO:0030234	enzyme regulator activity	MF
GO:0031501	mannosyltransferase complex	CC
GO:0031984	organelle subcompartment	CC
GO:0032991	protein-containing complex	CC
GO:0033185	dolichol-phosphate-mannose synthase complex	CC
GO:0034645	cellular macromolecule biosynthetic process	BP
GO:0035268	protein mannosylation	BP
GO:0035269	protein O-linked mannosylation	BP
GO:0036211	protein modification process	BP
GO:0042157	lipoprotein metabolic process	BP
GO:0042158	lipoprotein biosynthetic process	BP
GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	CC
GO:0043170	macromolecule metabolic process	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0043412	macromolecule modification	BP
GO:0043413	macromolecule glycosylation	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044249	cellular biosynthetic process	BP
GO:0044255	cellular lipid metabolic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044267	protein metabolic process	BP
GO:0044281	small molecule metabolic process	BP
GO:0044422	obsolete organelle part	CC
GO:0044424	obsolete intracellular part	CC
GO:0044425	obsolete membrane part	CC
GO:0044432	obsolete endoplasmic reticulum part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044446	obsolete intracellular organelle part	CC
GO:0044464	obsolete cell part	CC
GO:0045017	glycerolipid biosynthetic process	BP
GO:0046467	membrane lipid biosynthetic process	BP
GO:0046474	glycerophospholipid biosynthetic process	BP
GO:0046486	glycerolipid metabolic process	BP
GO:0046488	phosphatidylinositol metabolic process	BP
GO:0050790	regulation of catalytic activity	BP
GO:0065007	biological regulation	BP
GO:0065009	regulation of molecular function	BP
GO:0070085	glycosylation	BP
GO:0071704	organic substance metabolic process	BP
GO:0090407	organophosphate biosynthetic process	BP
GO:0097502	mannosylation	BP
GO:0098772	molecular function regulator activity	MF
GO:0098827	endoplasmic reticulum subcompartment	CC
GO:1901135	carbohydrate derivative metabolic process	BP
GO:1901137	carbohydrate derivative biosynthetic process	BP
GO:1901564	organonitrogen compound metabolic process	BP
GO:1901566	organonitrogen compound biosynthetic process	BP
GO:1901576	organic substance biosynthetic process	BP
GO:1901615	organic hydroxy compound metabolic process	BP
GO:1902494	catalytic complex	CC
GO:1903509	liposaccharide metabolic process	BP
GO:1990234	transferase complex	CC

KEGG Term	Name	Description
map01100	Metabolic pathways	-
map00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis gene result in a genetic disorder, paroxysmal nocturnal hemoglobinuria.
map00510	N-Glycan biosynthesis	N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119].