Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0000375 | RNA splicing, via transesterification reactions | BP |
| GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | BP |
| GO:0000398 | mRNA splicing, via spliceosome | BP |
| GO:0000932 | P-body | CC |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005634 | nucleus | CC |
| GO:0005681 | spliceosomal complex | CC |
| GO:0005688 | U6 snRNP | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005829 | cytosol | CC |
| GO:0006139 | nucleobase-containing compound metabolic process | BP |
| GO:0006396 | RNA processing | BP |
| GO:0006397 | mRNA processing | BP |
| GO:0006725 | cellular aromatic compound metabolic process | BP |
| GO:0006807 | nitrogen compound metabolic process | BP |
| GO:0008150 | biological_process | BP |
| GO:0008152 | metabolic process | BP |
| GO:0008380 | RNA splicing | BP |
| GO:0009987 | cellular process | BP |
| GO:0010467 | gene expression | BP |
| GO:0016070 | RNA metabolic process | BP |
| GO:0016071 | mRNA metabolic process | BP |
| GO:0030532 | small nuclear ribonucleoprotein complex | CC |
| GO:0032991 | protein-containing complex | CC |
| GO:0034641 | cellular nitrogen compound metabolic process | BP |
| GO:0035770 | ribonucleoprotein granule | CC |
| GO:0036464 | cytoplasmic ribonucleoprotein granule | CC |
| GO:0043170 | macromolecule metabolic process | BP |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043228 | non-membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043231 | intracellular membrane-bounded organelle | CC |
| GO:0043232 | intracellular non-membrane-bounded organelle | CC |
| GO:0044237 | cellular metabolic process | BP |
| GO:0044238 | primary metabolic process | BP |
| GO:0044422 | obsolete organelle part | CC |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044428 | obsolete nuclear part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044446 | obsolete intracellular organelle part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0046483 | heterocycle metabolic process | BP |
| GO:0046540 | U4/U6 x U5 tri-snRNP complex | CC |
| GO:0071011 | precatalytic spliceosome | CC |
| GO:0071013 | catalytic step 2 spliceosome | CC |
| GO:0071704 | organic substance metabolic process | BP |
| GO:0090304 | nucleic acid metabolic process | BP |
| GO:0097525 | spliceosomal snRNP complex | CC |
| GO:0097526 | spliceosomal tri-snRNP complex | CC |
| GO:0120114 | Sm-like protein family complex | CC |
| GO:1901360 | organic cyclic compound metabolic process | BP |
| GO:1902494 | catalytic complex | CC |
| GO:1990726 | Lsm1-7-Pat1 complex | CC |
| GO:1990904 | ribonucleoprotein complex | CC |
| KEGG Term | Name | Description |
|---|---|---|
| map03040 | Spliceosome | After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. |
| map03018 | RNA degradation | The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. |

