Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
gene-IMY05_C2497000400
View in Genome Browser
Position
JAEQKX010000342.1:19098-21783 (-)
2685bp
Gene Type
gene
Gene Description (Protein Product)
Belongs to the MRE11 RAD32 family
Organism
Salix suchowensis
Also AS AT5G54260

Gene Structure

upstream:
Get Sequence

Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
gene-IMY05_C4349000200 DNA helicase
gene-IMY05_C4891000100 four-way junction helicase activity
gene-IMY05_C4940000100 Belongs to the helicase family. RecQ subfamily

Load All Networks

Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000003 reproduction BP
GO:0000014 single-stranded DNA endodeoxyribonuclease activity MF
GO:0000075 cell cycle checkpoint signaling BP
GO:0000077 DNA damage checkpoint signaling BP
GO:0000217 DNA secondary structure binding MF
GO:0000228 nuclear chromosome CC
GO:0000278 mitotic cell cycle BP
GO:0000280 nuclear division BP
GO:0000403 Y-form DNA binding MF
GO:0000706 meiotic DNA double-strand break processing BP
GO:0000723 telomere maintenance BP
GO:0000724 double-strand break repair via homologous recombination BP
GO:0000725 recombinational repair BP
GO:0000726 obsolete non-recombinational repair BP
GO:0000727 double-strand break repair via break-induced replication BP
GO:0000729 DNA double-strand break processing BP
GO:0000781 chromosome, telomeric region CC
GO:0000784 chromosome, telomeric region CC
GO:0000785 chromatin CC
GO:0000792 heterochromatin CC
GO:0003006 developmental process involved in reproduction BP
GO:0003674 molecular_function MF
GO:0003676 nucleic acid binding MF
GO:0003677 DNA binding MF
GO:0003690 double-stranded DNA binding MF
GO:0003691 double-stranded telomeric DNA binding MF
GO:0003697 single-stranded DNA binding MF
GO:0003824 catalytic activity MF
GO:0004518 nuclease activity MF
GO:0004519 endonuclease activity MF
GO:0004520 DNA endonuclease activity MF
GO:0004527 exonuclease activity MF
GO:0004529 DNA exonuclease activity MF
GO:0004536 deoxyribonuclease activity MF
GO:0005198 structural molecule activity MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005694 chromosome CC
GO:0005737 cytoplasm CC
GO:0005739 mitochondrion CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006281 DNA repair BP
GO:0006284 base-excision repair BP
GO:0006302 double-strand break repair BP
GO:0006303 double-strand break repair via nonhomologous end joining BP
GO:0006310 DNA recombination BP
GO:0006355 regulation of DNA-templated transcription BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0006996 organelle organization BP
GO:0007049 cell cycle BP
GO:0007093 mitotic cell cycle checkpoint signaling BP
GO:0007127 meiosis I BP
GO:0007131 reciprocal meiotic recombination BP
GO:0007154 cell communication BP
GO:0007165 signal transduction BP
GO:0007346 regulation of mitotic cell cycle BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008296 3'-5'-DNA exonuclease activity MF
GO:0008297 single-stranded DNA exodeoxyribonuclease activity MF
GO:0008309 double-stranded DNA exodeoxyribonuclease activity MF
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity MF
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity MF
GO:0008408 3'-5' exonuclease activity MF
GO:0009653 anatomical structure morphogenesis BP
GO:0009889 regulation of biosynthetic process BP
GO:0009987 cellular process BP
GO:0010468 regulation of gene expression BP
GO:0010556 regulation of macromolecule biosynthetic process BP
GO:0010705 meiotic DNA double-strand break processing involved in reciprocal meiotic recombination BP
GO:0010791 DNA double-strand break processing involved in repair via synthesis-dependent strand annealing BP
GO:0016043 cellular component organization BP
GO:0016787 hydrolase activity MF
GO:0016788 hydrolase activity, acting on ester bonds MF
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters MF
GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters MF
GO:0019219 regulation of nucleobase-containing compound metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019953 sexual reproduction BP
GO:0022402 cell cycle process BP
GO:0022413 reproductive process in single-celled organism BP
GO:0022414 reproductive process BP
GO:0023052 signaling BP
GO:0030145 manganese ion binding MF
GO:0030154 cell differentiation BP
GO:0030435 sporulation resulting in formation of a cellular spore BP
GO:0030437 ascospore formation BP
GO:0030870 Mre11 complex CC
GO:0031323 regulation of cellular metabolic process BP
GO:0031326 regulation of cellular biosynthetic process BP
GO:0031570 DNA integrity checkpoint signaling BP
GO:0031573 mitotic intra-S DNA damage checkpoint signaling BP
GO:0031974 membrane-enclosed lumen CC
GO:0031981 nuclear lumen CC
GO:0032200 telomere organization BP
GO:0032502 developmental process BP
GO:0032505 reproduction of a single-celled organism BP
GO:0032947 molecular adaptor activity MF
GO:0032991 protein-containing complex CC
GO:0033554 cellular response to stress BP
GO:0034293 sexual sporulation BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0035556 intracellular signal transduction BP
GO:0035753 maintenance of DNA trinucleotide repeats BP
GO:0035825 homologous recombination BP
GO:0035861 site of double-strand break CC
GO:0042138 meiotic DNA double-strand break formation BP
GO:0042162 telomeric DNA binding MF
GO:0042592 homeostatic process BP
GO:0042769 obsolete DNA damage response, detection of DNA damage BP
GO:0042770 signal transduction in response to DNA damage BP
GO:0043047 single-stranded telomeric DNA binding MF
GO:0043167 ion binding MF
GO:0043169 cation binding MF
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0043565 sequence-specific DNA binding MF
GO:0043570 maintenance of DNA repeat elements BP
GO:0043934 sporulation BP
GO:0043935 sexual sporulation resulting in formation of a cellular spore BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044427 obsolete chromosomal part CC
GO:0044428 obsolete nuclear part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044454 obsolete nuclear chromosome part CC
GO:0044464 obsolete cell part CC
GO:0044703 multi-organism reproductive process BP
GO:0044773 mitotic DNA damage checkpoint signaling BP
GO:0044774 mitotic DNA integrity checkpoint signaling BP
GO:0045003 double-strand break repair via synthesis-dependent strand annealing BP
GO:0045027 DNA end binding MF
GO:0045786 negative regulation of cell cycle BP
GO:0045930 negative regulation of mitotic cell cycle BP
GO:0046483 heterocycle metabolic process BP
GO:0046872 metal ion binding MF
GO:0046914 transition metal ion binding MF
GO:0048285 organelle fission BP
GO:0048468 cell development BP
GO:0048519 negative regulation of biological process BP
GO:0048523 negative regulation of cellular process BP
GO:0048646 anatomical structure formation involved in morphogenesis BP
GO:0048856 anatomical structure development BP
GO:0048869 cellular developmental process BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051037 regulation of transcription involved in meiotic cell cycle BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051252 regulation of RNA metabolic process BP
GO:0051276 chromosome organization BP
GO:0051321 meiotic cell cycle BP
GO:0051606 detection of stimulus BP
GO:0051704 obsolete multi-organism process BP
GO:0051716 cellular response to stimulus BP
GO:0051726 regulation of cell cycle BP
GO:0051880 G-quadruplex DNA binding MF
GO:0060249 anatomical structure homeostasis BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0061982 meiosis I cell cycle process BP
GO:0065007 biological regulation BP
GO:0065008 regulation of biological quality BP
GO:0070013 intracellular organelle lumen CC
GO:0071704 organic substance metabolic process BP
GO:0071840 cellular component organization or biogenesis BP
GO:0072395 cell cycle checkpoint signaling BP
GO:0072401 DNA integrity checkpoint signaling BP
GO:0072422 DNA damage checkpoint signaling BP
GO:0080090 regulation of primary metabolic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0090305 nucleic acid phosphodiester bond hydrolysis BP
GO:0090734 site of DNA damage CC
GO:0097159 organic cyclic compound binding MF
GO:0097551 mitochondrial double-strand break repair BP
GO:0097552 mitochondrial double-strand break repair via homologous recombination BP
GO:0098687 chromosomal region CC
GO:0098847 sequence-specific single stranded DNA binding MF
GO:0140013 meiotic nuclear division BP
GO:0140097 catalytic activity, acting on DNA MF
GO:1901360 organic cyclic compound metabolic process BP
GO:1901363 heterocyclic compound binding MF
GO:1903046 meiotic cell cycle process BP
GO:1903047 mitotic cell cycle process BP
GO:1903506 regulation of nucleic acid-templated transcription BP
GO:1990421 chromosome, subtelomeric region CC
GO:1990898 meiotic DNA double-strand break clipping BP
GO:1990918 double-strand break repair involved in meiotic recombination BP
GO:2000112 regulation of cellular macromolecule biosynthetic process BP
GO:2001141 regulation of RNA biosynthetic process BP
KEGG Term Name Description
map03450 Non-homologous end-joining Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
map03440 Homologous recombination Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.