Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
gene-IMY05_C4514000300
View in Genome Browser
Position
JAEQKX010000723.1:34738-38034 (+)
3296bp
Gene Type
gene
Gene Description (Protein Product)
Belongs to the cullin family
Organism
Salix suchowensis
Also AS AT4G02570

Gene Structure

upstream:
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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
gene-IMY05_C4876000300 Anaphase-promoting complex subunit 11 RING-H2 finger
gene-IMY05_C4591000300 TATA-binding protein interacting (TIP20)
gene-IMY05_C4879000700 Belongs to the ubiquitin-conjugating enzyme family

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000082 G1/S transition of mitotic cell cycle BP
GO:0000086 G2/M transition of mitotic cell cycle BP
GO:0000151 ubiquitin ligase complex CC
GO:0000152 nuclear ubiquitin ligase complex CC
GO:0000278 mitotic cell cycle BP
GO:0003674 molecular_function MF
GO:0003676 nucleic acid binding MF
GO:0003677 DNA binding MF
GO:0003688 DNA replication origin binding MF
GO:0003690 double-stranded DNA binding MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0006275 regulation of DNA replication BP
GO:0006508 proteolysis BP
GO:0006511 ubiquitin-dependent protein catabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0007049 cell cycle BP
GO:0007346 regulation of mitotic cell cycle BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008156 negative regulation of DNA replication BP
GO:0009056 catabolic process BP
GO:0009057 macromolecule catabolic process BP
GO:0009889 regulation of biosynthetic process BP
GO:0009890 negative regulation of biosynthetic process BP
GO:0009892 negative regulation of metabolic process BP
GO:0009987 cellular process BP
GO:0010498 proteasomal protein catabolic process BP
GO:0010556 regulation of macromolecule biosynthetic process BP
GO:0010558 negative regulation of macromolecule biosynthetic process BP
GO:0010564 regulation of cell cycle process BP
GO:0010605 negative regulation of macromolecule metabolic process BP
GO:0010948 negative regulation of cell cycle process BP
GO:0019005 SCF ubiquitin ligase complex CC
GO:0019219 regulation of nucleobase-containing compound metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019538 protein metabolic process BP
GO:0019899 enzyme binding MF
GO:0019941 modification-dependent protein catabolic process BP
GO:0022402 cell cycle process BP
GO:0030163 protein catabolic process BP
GO:0030174 regulation of DNA-templated DNA replication initiation BP
GO:0030674 protein-macromolecule adaptor activity MF
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process BP
GO:0031323 regulation of cellular metabolic process BP
GO:0031324 negative regulation of cellular metabolic process BP
GO:0031326 regulation of cellular biosynthetic process BP
GO:0031327 negative regulation of cellular biosynthetic process BP
GO:0031461 cullin-RING ubiquitin ligase complex CC
GO:0031625 ubiquitin protein ligase binding MF
GO:0032297 negative regulation of DNA-templated DNA replication initiation BP
GO:0032991 protein-containing complex CC
GO:0033262 regulation of nuclear cell cycle DNA replication BP
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process BP
GO:0043170 macromolecule metabolic process BP
GO:0043224 nuclear SCF ubiquitin ligase complex CC
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043565 sequence-specific DNA binding MF
GO:0043632 modification-dependent macromolecule catabolic process BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044248 cellular catabolic process BP
GO:0044257 protein catabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044265 cellular macromolecule catabolic process BP
GO:0044267 protein metabolic process BP
GO:0044389 ubiquitin-like protein ligase binding MF
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0044770 cell cycle phase transition BP
GO:0044772 mitotic cell cycle phase transition BP
GO:0044839 cell cycle G2/M phase transition BP
GO:0044843 cell cycle G1/S phase transition BP
GO:0045786 negative regulation of cell cycle BP
GO:0045930 negative regulation of mitotic cell cycle BP
GO:0045934 negative regulation of nucleobase-containing compound metabolic process BP
GO:0048519 negative regulation of biological process BP
GO:0048523 negative regulation of cellular process BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0051052 regulation of DNA metabolic process BP
GO:0051053 negative regulation of DNA metabolic process BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051172 negative regulation of nitrogen compound metabolic process BP
GO:0051603 proteolysis involved in protein catabolic process BP
GO:0051726 regulation of cell cycle BP
GO:0060090 molecular adaptor activity MF
GO:0060255 regulation of macromolecule metabolic process BP
GO:0065007 biological regulation BP
GO:0071704 organic substance metabolic process BP
GO:0080090 regulation of primary metabolic process BP
GO:0090329 regulation of DNA-templated DNA replication BP
GO:0097159 organic cyclic compound binding MF
GO:1901363 heterocyclic compound binding MF
GO:1901564 organonitrogen compound metabolic process BP
GO:1901565 organonitrogen compound catabolic process BP
GO:1901575 organic substance catabolic process BP
GO:1902494 catalytic complex CC
GO:1902576 negative regulation of nuclear cell cycle DNA replication BP
GO:1903047 mitotic cell cycle process BP
GO:1903463 regulation of mitotic cell cycle DNA replication BP
GO:1903464 negative regulation of mitotic cell cycle DNA replication BP
GO:1903466 regulation of mitotic DNA replication initiation BP
GO:1903467 negative regulation of mitotic DNA replication initiation BP
GO:1990234 transferase complex CC
GO:1990837 sequence-specific double-stranded DNA binding MF
GO:2000104 negative regulation of DNA-templated DNA replication BP
GO:2000112 regulation of cellular macromolecule biosynthetic process BP
GO:2000113 negative regulation of cellular macromolecule biosynthetic process BP
KEGG Term Name Description
map04141 Protein processing in endoplasmic reticulum The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
map04120 Ubiquitin mediated proteolysis Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.