Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
gene-IMY05_C4520000200
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Position
JAEQKX010000729.1:7934-9650 (+)
1716bp
Gene Type
gene
Gene Description (Protein Product)
Belongs to the ubiquitin-conjugating enzyme family
Organism
Salix suchowensis
Also AS AT5G41700

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
gene-IMY05_C4876000300 Anaphase-promoting complex subunit 11 RING-H2 finger
gene-IMY05_C4607000500 ubiquitin activating enzyme
gene-IMY05_C4607000600 ubiquitin activating enzyme

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000151 ubiquitin ligase complex CC
GO:0000152 nuclear ubiquitin ligase complex CC
GO:0000209 protein polyubiquitination BP
GO:0000502 proteasome complex CC
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0004842 ubiquitin-protein transferase activity MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005737 cytoplasm CC
GO:0006355 regulation of DNA-templated transcription BP
GO:0006357 regulation of transcription by RNA polymerase II BP
GO:0006464 protein modification process BP
GO:0006508 proteolysis BP
GO:0006511 ubiquitin-dependent protein catabolic process BP
GO:0006513 protein monoubiquitination BP
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006984 ER-nucleus signaling pathway BP
GO:0006991 response to sterol depletion BP
GO:0007088 regulation of mitotic nuclear division BP
GO:0007154 cell communication BP
GO:0007165 signal transduction BP
GO:0007346 regulation of mitotic cell cycle BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009056 catabolic process BP
GO:0009057 macromolecule catabolic process BP
GO:0009266 response to temperature stimulus BP
GO:0009408 response to heat BP
GO:0009628 response to abiotic stimulus BP
GO:0009889 regulation of biosynthetic process BP
GO:0009891 positive regulation of biosynthetic process BP
GO:0009893 positive regulation of metabolic process BP
GO:0009896 positive regulation of catabolic process BP
GO:0009987 cellular process BP
GO:0010033 response to organic substance BP
GO:0010467 gene expression BP
GO:0010468 regulation of gene expression BP
GO:0010498 proteasomal protein catabolic process BP
GO:0010556 regulation of macromolecule biosynthetic process BP
GO:0010557 positive regulation of macromolecule biosynthetic process BP
GO:0010559 regulation of glycoprotein biosynthetic process BP
GO:0010564 regulation of cell cycle process BP
GO:0010604 positive regulation of macromolecule metabolic process BP
GO:0010628 positive regulation of gene expression BP
GO:0010638 positive regulation of organelle organization BP
GO:0010965 regulation of mitotic sister chromatid separation BP
GO:0016485 protein processing BP
GO:0016567 protein ubiquitination BP
GO:0016740 transferase activity MF
GO:0019005 SCF ubiquitin ligase complex CC
GO:0019219 regulation of nucleobase-containing compound metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019538 protein metabolic process BP
GO:0019787 ubiquitin-like protein transferase activity MF
GO:0019941 modification-dependent protein catabolic process BP
GO:0023052 signaling BP
GO:0030071 regulation of mitotic metaphase/anaphase transition BP
GO:0030163 protein catabolic process BP
GO:0030674 protein-macromolecule adaptor activity MF
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process BP
GO:0031323 regulation of cellular metabolic process BP
GO:0031325 positive regulation of cellular metabolic process BP
GO:0031326 regulation of cellular biosynthetic process BP
GO:0031328 positive regulation of cellular biosynthetic process BP
GO:0031331 positive regulation of cellular catabolic process BP
GO:0031399 regulation of protein modification process BP
GO:0031461 cullin-RING ubiquitin ligase complex CC
GO:0032182 ubiquitin-like protein binding MF
GO:0032268 regulation of protein metabolic process BP
GO:0032270 positive regulation of protein metabolic process BP
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process BP
GO:0032446 protein modification by small protein conjugation BP
GO:0032933 SREBP signaling pathway BP
GO:0032991 protein-containing complex CC
GO:0033043 regulation of organelle organization BP
GO:0033044 regulation of chromosome organization BP
GO:0033045 regulation of sister chromatid segregation BP
GO:0033047 regulation of mitotic sister chromatid segregation BP
GO:0033554 cellular response to stress BP
GO:0034605 cellular response to heat BP
GO:0035103 sterol regulatory element binding protein cleavage BP
GO:0035966 response to topologically incorrect protein BP
GO:0035967 cellular response to topologically incorrect protein BP
GO:0036211 protein modification process BP
GO:0042221 response to chemical BP
GO:0043130 ubiquitin binding MF
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process BP
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway BP
GO:0043170 macromolecule metabolic process BP
GO:0043224 nuclear SCF ubiquitin ligase complex CC
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043412 macromolecule modification BP
GO:0043632 modification-dependent macromolecule catabolic process BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044248 cellular catabolic process BP
GO:0044257 protein catabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044265 cellular macromolecule catabolic process BP
GO:0044267 protein metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0045732 positive regulation of protein catabolic process BP
GO:0045787 positive regulation of cell cycle BP
GO:0045840 positive regulation of mitotic nuclear division BP
GO:0045842 positive regulation of mitotic metaphase/anaphase transition BP
GO:0045862 positive regulation of proteolysis BP
GO:0045893 positive regulation of DNA-templated transcription BP
GO:0045931 positive regulation of mitotic cell cycle BP
GO:0045935 positive regulation of nucleobase-containing compound metabolic process BP
GO:0045944 positive regulation of transcription by RNA polymerase II BP
GO:0048518 positive regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051128 regulation of cellular component organization BP
GO:0051130 positive regulation of cellular component organization BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051173 positive regulation of nitrogen compound metabolic process BP
GO:0051246 regulation of protein metabolic process BP
GO:0051247 positive regulation of protein metabolic process BP
GO:0051252 regulation of RNA metabolic process BP
GO:0051254 positive regulation of RNA metabolic process BP
GO:0051603 proteolysis involved in protein catabolic process BP
GO:0051604 protein maturation BP
GO:0051716 cellular response to stimulus BP
GO:0051726 regulation of cell cycle BP
GO:0051781 positive regulation of cell division BP
GO:0051783 regulation of nuclear division BP
GO:0051785 positive regulation of nuclear division BP
GO:0051788 response to misfolded protein BP
GO:0051983 regulation of chromosome segregation BP
GO:0051984 positive regulation of chromosome segregation BP
GO:0060049 regulation of protein glycosylation BP
GO:0060090 molecular adaptor activity MF
GO:0060255 regulation of macromolecule metabolic process BP
GO:0061631 ubiquitin conjugating enzyme activity MF
GO:0061650 ubiquitin-like protein conjugating enzyme activity MF
GO:0062033 positive regulation of mitotic sister chromatid segregation BP
GO:0065007 biological regulation BP
GO:0070647 protein modification by small protein conjugation or removal BP
GO:0070887 cellular response to chemical stimulus BP
GO:0071218 cellular response to misfolded protein BP
GO:0071310 cellular response to organic substance BP
GO:0071501 cellular response to sterol depletion BP
GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system BP
GO:0071704 organic substance metabolic process BP
GO:0080090 regulation of primary metabolic process BP
GO:0090068 positive regulation of cell cycle process BP
GO:0140096 catalytic activity, acting on a protein MF
GO:1901564 organonitrogen compound metabolic process BP
GO:1901565 organonitrogen compound catabolic process BP
GO:1901575 organic substance catabolic process BP
GO:1901800 positive regulation of proteasomal protein catabolic process BP
GO:1901970 positive regulation of mitotic sister chromatid separation BP
GO:1901987 regulation of cell cycle phase transition BP
GO:1901989 positive regulation of cell cycle phase transition BP
GO:1901990 regulation of mitotic cell cycle phase transition BP
GO:1901992 positive regulation of mitotic cell cycle phase transition BP
GO:1902099 regulation of metaphase/anaphase transition of cell cycle BP
GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle BP
GO:1902494 catalytic complex CC
GO:1902680 positive regulation of RNA biosynthetic process BP
GO:1903018 regulation of glycoprotein metabolic process BP
GO:1903052 positive regulation of proteolysis involved in protein catabolic process BP
GO:1903364 positive regulation of protein catabolic process BP
GO:1903506 regulation of nucleic acid-templated transcription BP
GO:1903508 positive regulation of nucleic acid-templated transcription BP
GO:1905368 peptidase complex CC
GO:1905369 endopeptidase complex CC
GO:1905818 regulation of chromosome separation BP
GO:1905820 positive regulation of chromosome separation BP
GO:1990234 transferase complex CC
GO:2000112 regulation of cellular macromolecule biosynthetic process BP
GO:2001141 regulation of RNA biosynthetic process BP
GO:2001252 positive regulation of chromosome organization BP
KEGG Term Name Description
map04141 Protein processing in endoplasmic reticulum The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
map04120 Ubiquitin mediated proteolysis Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.