Basic Information
Gene ID
gene-IMY05_C4910000200
Position
JAEQKX010001094.1:13608-14764 (-)
1156bp
Gene Type
gene
Gene Description (Protein Product)
GLE1-like protein
Organism
Also AS

Gene Structure

upstream:

Domain
Database EntryID E-Value Start end InterPro ID Description


Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
GO Term Description GO Category
GO:0000822 inositol hexakisphosphate binding MF
GO:0003674 molecular_function MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005543 phospholipid binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005635 nuclear envelope CC
GO:0005643 nuclear pore CC
GO:0005737 cytoplasm CC
GO:0005739 mitochondrion CC
GO:0006403 RNA localization BP
GO:0006405 RNA export from nucleus BP
GO:0006406 mRNA export from nucleus BP
GO:0006417 regulation of translation BP
GO:0006446 regulation of translational initiation BP
GO:0006449 regulation of translational termination BP
GO:0006611 protein export from nucleus BP
GO:0006810 transport BP
GO:0006886 intracellular protein transport BP
GO:0006913 nucleocytoplasmic transport BP
GO:0008047 enzyme activator activity MF
GO:0008104 protein localization BP
GO:0008144 obsolete drug binding MF
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008289 lipid binding MF
GO:0009889 regulation of biosynthetic process BP
GO:0010467 gene expression BP
GO:0010468 regulation of gene expression BP
GO:0010556 regulation of macromolecule biosynthetic process BP
GO:0010608 post-transcriptional regulation of gene expression BP
GO:0012505 endomembrane system CC
GO:0015031 protein transport BP
GO:0015833 peptide transport BP
GO:0015931 nucleobase-containing compound transport BP
GO:0016020 membrane CC
GO:0016021 membrane CC
GO:0016973 poly(A)+ mRNA export from nucleus BP
GO:0019222 regulation of metabolic process BP
GO:0030234 enzyme regulator activity MF
GO:0031224 obsolete intrinsic component of membrane CC
GO:0031323 regulation of cellular metabolic process BP
GO:0031326 regulation of cellular biosynthetic process BP
GO:0031369 translation initiation factor binding MF
GO:0031503 protein-containing complex localization BP
GO:0031967 organelle envelope CC
GO:0031974 membrane-enclosed lumen CC
GO:0031975 envelope CC
GO:0031981 nuclear lumen CC
GO:0032268 regulation of protein metabolic process BP
GO:0032991 protein-containing complex CC
GO:0033036 macromolecule localization BP
GO:0034248 regulation of amide metabolic process BP
GO:0034399 nuclear periphery CC
GO:0034613 protein localization BP
GO:0036094 small molecule binding MF
GO:0042886 amide transport BP
GO:0043085 positive regulation of catalytic activity BP
GO:0043167 ion binding MF
GO:0043168 anion binding MF
GO:0043170 macromolecule metabolic process BP
GO:0043178 alcohol binding MF
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0043244 regulation of protein-containing complex disassembly BP
GO:0044093 positive regulation of molecular function BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044425 obsolete membrane part CC
GO:0044428 obsolete nuclear part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0044614 nuclear pore cytoplasmic filaments CC
GO:0045184 establishment of protein localization BP
GO:0046907 intracellular transport BP
GO:0050657 nucleic acid transport BP
GO:0050658 RNA transport BP
GO:0050789 regulation of biological process BP
GO:0050790 regulation of catalytic activity BP
GO:0050794 regulation of cellular process BP
GO:0051028 mRNA transport BP
GO:0051128 regulation of cellular component organization BP
GO:0051168 nuclear export BP
GO:0051169 nuclear transport BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051179 localization BP
GO:0051234 establishment of localization BP
GO:0051236 establishment of RNA localization BP
GO:0051246 regulation of protein metabolic process BP
GO:0051641 cellular localization BP
GO:0051649 establishment of localization in cell BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0065007 biological regulation BP
GO:0065009 regulation of molecular function BP
GO:0070013 intracellular organelle lumen CC
GO:0070727 cellular macromolecule localization BP
GO:0071166 ribonucleoprotein complex localization BP
GO:0071426 obsolete ribonucleoprotein complex export from nucleus BP
GO:0071427 obsolete mRNA-containing ribonucleoprotein complex export from nucleus BP
GO:0071702 organic substance transport BP
GO:0071704 organic substance metabolic process BP
GO:0071705 nitrogen compound transport BP
GO:0080090 regulation of primary metabolic process BP
GO:0098772 molecular function regulator activity MF
GO:2000112 regulation of cellular macromolecule biosynthetic process BP
KEGG Term Name Description
map03015 mRNA surveillance pathway The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
map03013 RNA transport RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation.