PPGR - Gene Detail

Basic Information

Gene ID	SESE_111277.g View in Genome Browser
Position	Scaffold_58921:1-12784 (+) 12783bp
Gene Type	gene
Gene Description (Protein Product)	COP9 signalosome complex subunit
Organism	Sequoia sempervirens
Also AS	AT5G42970

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Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

SESE_146426.g protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Involved in CSN's deneddylation derubylation activity. Required for the deneddylation of all cullins. Essential for the structural integrity of the CSN holocomplex

SESE_111512.g COP9 signalosome complex subunit

SESE_121556.g JAB/MPN domain

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Pathway

GO Term	Description	GO Category
GO:0000338	protein deneddylation	BP
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005634	nucleus	CC
GO:0005737	cytoplasm	CC
GO:0005829	cytosol	CC
GO:0006464	protein modification process	BP
GO:0006508	proteolysis	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0007346	regulation of mitotic cell cycle	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0008180	COP9 signalosome	CC
GO:0009987	cellular process	BP
GO:0010389	regulation of G2/M transition of mitotic cell cycle	BP
GO:0010564	regulation of cell cycle process	BP
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	BP
GO:0019538	protein metabolic process	BP
GO:0032991	protein-containing complex	CC
GO:0036211	protein modification process	BP
GO:0043170	macromolecule metabolic process	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0043412	macromolecule modification	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044267	protein metabolic process	BP
GO:0044422	obsolete organelle part	CC
GO:0044424	obsolete intracellular part	CC
GO:0044428	obsolete nuclear part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044446	obsolete intracellular organelle part	CC
GO:0044464	obsolete cell part	CC
GO:0045787	positive regulation of cell cycle	BP
GO:0045931	positive regulation of mitotic cell cycle	BP
GO:0048518	positive regulation of biological process	BP
GO:0048522	positive regulation of cellular process	BP
GO:0050789	regulation of biological process	BP
GO:0050794	regulation of cellular process	BP
GO:0051726	regulation of cell cycle	BP
GO:0065007	biological regulation	BP
GO:0070646	protein modification by small protein removal	BP
GO:0070647	protein modification by small protein conjugation or removal	BP
GO:0071704	organic substance metabolic process	BP
GO:0090068	positive regulation of cell cycle process	BP
GO:1901564	organonitrogen compound metabolic process	BP
GO:1901987	regulation of cell cycle phase transition	BP
GO:1901989	positive regulation of cell cycle phase transition	BP
GO:1901990	regulation of mitotic cell cycle phase transition	BP
GO:1901992	positive regulation of mitotic cell cycle phase transition	BP
GO:1902749	regulation of cell cycle G2/M phase transition	BP
GO:1902751	positive regulation of cell cycle G2/M phase transition	BP