PPGR - Gene Detail

Basic Information

Gene ID	EVM0023464 View in Genome Browser
Position	GWHASIS00000001:6070462-6076802 (-) 6340bp
Gene Type	gene
Gene Description (Protein Product)	Threonylcarbamoyladenosine tRNA
Organism	Acer catalpifolium
Also AS	AT1G72090

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

EVM0027179 Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys); tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs; an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

EVM0027717 Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys); tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP); then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently; a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor

EVM0025613 tRNA (Guanine(26)-N(2))-dimethyltransferase

Regulatory gene

EVM0000098 DnaJ homolog; subfamily C; member

EVM0001481 Transcription factor

EVM0003288 transcription factor

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Pathway

GO Term	Description	GO Category
GO:0003674	molecular_function	MF
GO:0003824	catalytic activity	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005737	cytoplasm	CC
GO:0005783	endoplasmic reticulum	CC
GO:0006139	nucleobase-containing compound metabolic process	BP
GO:0006396	RNA processing	BP
GO:0006399	tRNA metabolic process	BP
GO:0006400	tRNA modification	BP
GO:0006725	cellular aromatic compound metabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0008033	tRNA processing	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0009451	RNA modification	BP
GO:0009987	cellular process	BP
GO:0010467	gene expression	BP
GO:0012505	endomembrane system	CC
GO:0016070	RNA metabolic process	BP
GO:0016740	transferase activity	MF
GO:0016782	transferase activity, transferring sulphur-containing groups	MF
GO:0034470	ncRNA processing	BP
GO:0034641	cellular nitrogen compound metabolic process	BP
GO:0034660	ncRNA metabolic process	BP
GO:0035596	methylthiotransferase activity	MF
GO:0035598	N6-threonylcarbomyladenosine methylthiotransferase activity	MF
GO:0035600	tRNA methylthiolation	BP
GO:0043170	macromolecule metabolic process	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0043412	macromolecule modification	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044424	obsolete intracellular part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044464	obsolete cell part	CC
GO:0046483	heterocycle metabolic process	BP
GO:0050497	alkylthioltransferase activity	MF
GO:0071704	organic substance metabolic process	BP
GO:0090304	nucleic acid metabolic process	BP
GO:1901360	organic cyclic compound metabolic process	BP