Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
EVM0028573
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Position
GWHASIS00001971:32387972-32394493 (+)
6521bp
Gene Type
gene
Gene Description (Protein Product)
DNA polymerase
Organism
Acer catalpifolium
Also AS AT1G10520

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
EVM0029460 DNA-(Apurinic or apyrimidinic site) lyase
EVM0031220 DNA-(Apurinic or apyrimidinic site) lyase
EVM0033944 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication; cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base; leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway; by cleaving within the apurinic apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA; and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA
Regulatory gene
EVM0000322 G-box-binding factor
EVM0000691 radialis-like
EVM0001273 -

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000724 double-strand break repair via homologous recombination BP
GO:0000725 recombinational repair BP
GO:0000726 obsolete non-recombinational repair BP
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0003887 DNA-directed DNA polymerase activity MF
GO:0005488 binding MF
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006281 DNA repair BP
GO:0006284 base-excision repair BP
GO:0006285 base-excision repair, AP site formation BP
GO:0006287 base-excision repair, gap-filling BP
GO:0006302 double-strand break repair BP
GO:0006303 double-strand break repair via nonhomologous end joining BP
GO:0006310 DNA recombination BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009987 cellular process BP
GO:0016740 transferase activity MF
GO:0016772 transferase activity, transferring phosphorus-containing groups MF
GO:0016779 nucleotidyltransferase activity MF
GO:0016829 lyase activity MF
GO:0016835 carbon-oxygen lyase activity MF
GO:0018130 heterocycle biosynthetic process BP
GO:0019438 aromatic compound biosynthetic process BP
GO:0030145 manganese ion binding MF
GO:0033554 cellular response to stress BP
GO:0034061 DNA polymerase activity MF
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0034654 nucleobase-containing compound biosynthetic process BP
GO:0043167 ion binding MF
GO:0043169 cation binding MF
GO:0043170 macromolecule metabolic process BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044271 cellular nitrogen compound biosynthetic process BP
GO:0046483 heterocycle metabolic process BP
GO:0046872 metal ion binding MF
GO:0046914 transition metal ion binding MF
GO:0050896 response to stimulus BP
GO:0051575 5'-deoxyribose-5-phosphate lyase activity MF
GO:0051716 cellular response to stimulus BP
GO:0071704 organic substance metabolic process BP
GO:0071897 DNA biosynthetic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0097510 base-excision repair, AP site formation via deaminated base removal BP
GO:0140097 catalytic activity, acting on DNA MF
GO:1901360 organic cyclic compound metabolic process BP
GO:1901362 organic cyclic compound biosynthetic process BP
GO:1901576 organic substance biosynthetic process BP
KEGG Term Name Description
map03450 Non-homologous end-joining Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
map03410 Base excision repair Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.