PPGR - Gene Detail

Basic Information

Gene ID	AmTr_scaff00142.47.v1.0.g View in Genome Browser
Position	AmTr_scaff00142:814917-815666 (+) 749bp
Gene Type	gene
Gene Description (Protein Product)	DNA repair and recombination protein
Organism	Amborella trichopoda
Also AS	AT1G05490AMTR_s00142p00075140

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

AmTr_scaff00147.45.v1.0.g Methylenetetrahydrofolate reductase

AmTr_scaff00145.9.v1.0.g DNA repair protein RAD51 homolog

AmTr_scaff00202.13.v1.0.g Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand

Load All Networks

Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Pathway

KEGG Term	Name	Description
map03440	Homologous recombination	Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.