PPGR - Gene Detail

Basic Information

Gene Structure

Domain

Regulation&
Interaction

Annotation

Orthologus Group

Expresssion

Pathway

Basic Information

Gene ID	CSS0019886.g View in Genome Browser
Position	Chr4:189114388-189116621 (-) 2233bp
Gene Type	gene
Gene Description (Protein Product)	"BRCA2
Organism	Camellia sinensis
Also AS	AT5G01630

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

CSS0036462.g Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination

CSS0040764.g Protein BREAST CANCER SUSCEPTIBILITY 1 homolog

CSS0035665.g BRCT domain-containing protein

Regulatory gene

CSS0004360.g Dof zinc finger protein

CSS0004951.g dof zinc finger protein

CSS0012691.g Dof zinc finger protein

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Expression Profile

DataSet	Number of Samples expressed(TPM>1)	Mean	Min	Max	Standard deviation(SD)	Coeffcient variation(CV)

Select Expression

Pathway

GO Term	Description	GO Category
GO:0000003	reproduction	BP
GO:0000226	microtubule cytoskeleton organization	BP
GO:0000228	nuclear chromosome	CC
GO:0000278	mitotic cell cycle	BP
GO:0000280	nuclear division	BP
GO:0000281	mitotic cytokinesis	BP
GO:0000722	telomere maintenance via recombination	BP
GO:0000723	telomere maintenance	BP
GO:0000724	double-strand break repair via homologous recombination	BP
GO:0000725	recombinational repair	BP
GO:0000781	chromosome, telomeric region	CC
GO:0000784	chromosome, telomeric region	CC
GO:0000793	condensed chromosome	CC
GO:0000794	condensed nuclear chromosome	CC
GO:0000795	synaptonemal complex	CC
GO:0000800	lateral element	CC
GO:0000910	cytokinesis	BP
GO:0001556	oocyte maturation	BP
GO:0001701	in utero embryonic development	BP
GO:0001824	blastocyst development	BP
GO:0001832	blastocyst growth	BP
GO:0001833	inner cell mass cell proliferation	BP
GO:0002020	protease binding	MF
GO:0002376	immune system process	BP
GO:0002520	immune system development	BP
GO:0003006	developmental process involved in reproduction	BP
GO:0003674	molecular_function	MF
GO:0003676	nucleic acid binding	MF
GO:0003677	DNA binding	MF
GO:0003697	single-stranded DNA binding	MF
GO:0003824	catalytic activity	MF
GO:0004402	histone acetyltransferase activity	MF
GO:0005488	binding	MF
GO:0005515	protein binding	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005634	nucleus	CC
GO:0005654	nucleoplasm	CC
GO:0005694	chromosome	CC
GO:0005737	cytoplasm	CC
GO:0005739	mitochondrion	CC
GO:0005813	centrosome	CC
GO:0005815	microtubule organizing center	CC
GO:0005829	cytosol	CC
GO:0005856	cytoskeleton	CC
GO:0006139	nucleobase-containing compound metabolic process	BP
GO:0006259	DNA metabolic process	BP
GO:0006260	DNA replication	BP
GO:0006261	DNA-templated DNA replication	BP
GO:0006275	regulation of DNA replication	BP
GO:0006281	DNA repair	BP
GO:0006289	nucleotide-excision repair	BP
GO:0006302	double-strand break repair	BP
GO:0006310	DNA recombination	BP
GO:0006312	mitotic recombination	BP
GO:0006325	chromatin organization	BP
GO:0006355	regulation of DNA-templated transcription	BP
GO:0006464	protein modification process	BP
GO:0006473	protein acetylation	BP
GO:0006475	internal protein amino acid acetylation	BP
GO:0006725	cellular aromatic compound metabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0006915	apoptotic process	BP
GO:0006950	response to stress	BP
GO:0006974	cellular response to DNA damage stimulus	BP
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	BP
GO:0006996	organelle organization	BP
GO:0007010	cytoskeleton organization	BP
GO:0007017	microtubule-based process	BP
GO:0007049	cell cycle	BP
GO:0007059	chromosome segregation	BP
GO:0007098	centrosome cycle	BP
GO:0007127	meiosis I	BP
GO:0007140	male meiotic nuclear division	BP
GO:0007141	male meiosis I	BP
GO:0007154	cell communication	BP
GO:0007165	signal transduction	BP
GO:0007275	multicellular organism development	BP
GO:0007276	gamete generation	BP
GO:0007281	germ cell development	BP
GO:0007283	spermatogenesis	BP
GO:0007292	female gamete generation	BP
GO:0007346	regulation of mitotic cell cycle	BP
GO:0007399	nervous system development	BP
GO:0007417	central nervous system development	BP
GO:0007420	brain development	BP
GO:0007548	sex differentiation	BP
GO:0007568	aging	BP
GO:0007569	obsolete cell aging	BP
GO:0008022	obsolete protein C-terminus binding	MF
GO:0008080	N-acetyltransferase activity	MF
GO:0008092	cytoskeletal protein binding	MF
GO:0008104	protein localization	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0008156	negative regulation of DNA replication	BP
GO:0008219	cell death	BP
GO:0008283	cell population proliferation	BP
GO:0008285	negative regulation of cell population proliferation	BP
GO:0008406	gonad development	BP
GO:0008585	female gonad development	BP
GO:0008608	attachment of spindle microtubules to kinetochore	BP
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	BP
GO:0009058	biosynthetic process	BP
GO:0009059	macromolecule biosynthetic process	BP
GO:0009314	response to radiation	BP
GO:0009411	response to UV	BP
GO:0009416	response to light stimulus	BP
GO:0009628	response to abiotic stimulus	BP
GO:0009790	embryo development	BP
GO:0009792	embryo development ending in birth or egg hatching	BP
GO:0009889	regulation of biosynthetic process	BP
GO:0009890	negative regulation of biosynthetic process	BP
GO:0009891	positive regulation of biosynthetic process	BP
GO:0009892	negative regulation of metabolic process	BP
GO:0009893	positive regulation of metabolic process	BP
GO:0009987	cellular process	BP
GO:0009994	oocyte differentiation	BP
GO:0010165	response to X-ray	BP
GO:0010212	response to ionizing radiation	BP
GO:0010225	response to UV-C	BP
GO:0010332	response to gamma radiation	BP
GO:0010468	regulation of gene expression	BP
GO:0010484	histone H3 acetyltransferase activity	MF
GO:0010485	histone H4 acetyltransferase activity	MF
GO:0010556	regulation of macromolecule biosynthetic process	BP
GO:0010557	positive regulation of macromolecule biosynthetic process	BP
GO:0010558	negative regulation of macromolecule biosynthetic process	BP
GO:0010564	regulation of cell cycle process	BP
GO:0010604	positive regulation of macromolecule metabolic process	BP
GO:0010605	negative regulation of macromolecule metabolic process	BP
GO:0010628	positive regulation of gene expression	BP
GO:0012501	programmed cell death	BP
GO:0012505	endomembrane system	CC
GO:0015630	microtubule cytoskeleton	CC
GO:0015631	tubulin binding	MF
GO:0016043	cellular component organization	BP
GO:0016407	acetyltransferase activity	MF
GO:0016410	N-acyltransferase activity	MF
GO:0016569	obsolete covalent chromatin modification	BP
GO:0016570	histone modification	BP
GO:0016573	histone acetylation	BP
GO:0016740	transferase activity	MF
GO:0016746	acyltransferase activity	MF
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	MF
GO:0018193	peptidyl-amino acid modification	BP
GO:0018205	peptidyl-lysine modification	BP
GO:0018393	internal peptidyl-lysine acetylation	BP
GO:0018394	peptidyl-lysine acetylation	BP
GO:0019219	regulation of nucleobase-containing compound metabolic process	BP
GO:0019222	regulation of metabolic process	BP
GO:0019538	protein metabolic process	BP
GO:0019899	enzyme binding	MF
GO:0019953	sexual reproduction	BP
GO:0021700	developmental maturation	BP
GO:0022402	cell cycle process	BP
GO:0022412	cellular process involved in reproduction in multicellular organism	BP
GO:0022414	reproductive process	BP
GO:0023052	signaling	BP
GO:0030097	hemopoiesis	BP
GO:0030141	secretory granule	CC
GO:0030154	cell differentiation	BP
GO:0030330	DNA damage response, signal transduction by p53 class mediator	BP
GO:0030879	mammary gland development	BP
GO:0031023	microtubule organizing center organization	BP
GO:0031297	replication fork processing	BP
GO:0031323	regulation of cellular metabolic process	BP
GO:0031324	negative regulation of cellular metabolic process	BP
GO:0031325	positive regulation of cellular metabolic process	BP
GO:0031326	regulation of cellular biosynthetic process	BP
GO:0031327	negative regulation of cellular biosynthetic process	BP
GO:0031328	positive regulation of cellular biosynthetic process	BP
GO:0031410	cytoplasmic vesicle	CC
GO:0031619	homologous chromosome orientation involved in meiotic metaphase I plate congression	BP
GO:0031974	membrane-enclosed lumen	CC
GO:0031981	nuclear lumen	CC
GO:0031982	vesicle	CC
GO:0032200	telomere organization	BP
GO:0032465	regulation of cytokinesis	BP
GO:0032501	multicellular organismal process	BP
GO:0032502	developmental process	BP
GO:0032504	multicellular organism reproduction	BP
GO:0032991	protein-containing complex	CC
GO:0033036	macromolecule localization	BP
GO:0033260	nuclear DNA replication	BP
GO:0033365	protein localization to organelle	BP
GO:0033554	cellular response to stress	BP
GO:0033593	BRCA2-MAGE-D1 complex	CC
GO:0033599	regulation of mammary gland epithelial cell proliferation	BP
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	BP
GO:0034212	peptide N-acetyltransferase activity	MF
GO:0034502	protein localization to chromosome	BP
GO:0034613	protein localization	BP
GO:0034641	cellular nitrogen compound metabolic process	BP
GO:0034645	cellular macromolecule biosynthetic process	BP
GO:0035264	multicellular organism growth	BP
GO:0035556	intracellular signal transduction	BP
GO:0036211	protein modification process	BP
GO:0040007	growth	BP
GO:0042127	regulation of cell population proliferation	BP
GO:0042592	homeostatic process	BP
GO:0042770	signal transduction in response to DNA damage	BP
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	BP
GO:0042772	DNA damage response, signal transduction resulting in transcription	BP
GO:0042802	identical protein binding	MF
GO:0043009	chordate embryonic development	BP
GO:0043015	gamma-tubulin binding	MF
GO:0043060	meiotic metaphase I plate congression	BP
GO:0043170	macromolecule metabolic process	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043228	non-membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0043232	intracellular non-membrane-bounded organelle	CC
GO:0043233	organelle lumen	CC
GO:0043412	macromolecule modification	BP
GO:0043543	protein acylation	BP
GO:0043966	histone H3 acetylation	BP
GO:0043967	histone H4 acetylation	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044249	cellular biosynthetic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044267	protein metabolic process	BP
GO:0044422	obsolete organelle part	CC
GO:0044424	obsolete intracellular part	CC
GO:0044427	obsolete chromosomal part	CC
GO:0044428	obsolete nuclear part	CC
GO:0044430	obsolete cytoskeletal part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044446	obsolete intracellular organelle part	CC
GO:0044454	obsolete nuclear chromosome part	CC
GO:0044464	obsolete cell part	CC
GO:0044703	multi-organism reproductive process	BP
GO:0044786	cell cycle DNA replication	BP
GO:0045005	DNA-templated DNA replication maintenance of fidelity	BP
GO:0045132	meiotic chromosome segregation	BP
GO:0045137	development of primary sexual characteristics	BP
GO:0045143	homologous chromosome segregation	BP
GO:0045184	establishment of protein localization	BP
GO:0045787	positive regulation of cell cycle	BP
GO:0045893	positive regulation of DNA-templated transcription	BP
GO:0045931	positive regulation of mitotic cell cycle	BP
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	BP
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	BP
GO:0046483	heterocycle metabolic process	BP
GO:0046545	development of primary female sexual characteristics	BP
GO:0046660	female sex differentiation	BP
GO:0048232	male gamete generation	BP
GO:0048285	organelle fission	BP
GO:0048468	cell development	BP
GO:0048469	cell maturation	BP
GO:0048477	oogenesis	BP
GO:0048478	replication fork protection	BP
GO:0048513	animal organ development	BP
GO:0048518	positive regulation of biological process	BP
GO:0048519	negative regulation of biological process	BP
GO:0048522	positive regulation of cellular process	BP
GO:0048523	negative regulation of cellular process	BP
GO:0048534	hematopoietic or lymphoid organ development	BP
GO:0048589	developmental growth	BP
GO:0048599	oocyte development	BP
GO:0048608	reproductive structure development	BP
GO:0048609	multicellular organismal reproductive process	BP
GO:0048731	system development	BP
GO:0048732	gland development	BP
GO:0048856	anatomical structure development	BP
GO:0048869	cellular developmental process	BP
GO:0050000	chromosome localization	BP
GO:0050678	regulation of epithelial cell proliferation	BP
GO:0050680	negative regulation of epithelial cell proliferation	BP
GO:0050789	regulation of biological process	BP
GO:0050793	regulation of developmental process	BP
GO:0050794	regulation of cellular process	BP
GO:0050896	response to stimulus	BP
GO:0051052	regulation of DNA metabolic process	BP
GO:0051053	negative regulation of DNA metabolic process	BP
GO:0051093	negative regulation of developmental process	BP
GO:0051171	regulation of nitrogen compound metabolic process	BP
GO:0051172	negative regulation of nitrogen compound metabolic process	BP
GO:0051173	positive regulation of nitrogen compound metabolic process	BP
GO:0051179	localization	BP
GO:0051234	establishment of localization	BP
GO:0051239	regulation of multicellular organismal process	BP
GO:0051241	negative regulation of multicellular organismal process	BP
GO:0051252	regulation of RNA metabolic process	BP
GO:0051254	positive regulation of RNA metabolic process	BP
GO:0051276	chromosome organization	BP
GO:0051298	centrosome duplication	BP
GO:0051301	cell division	BP
GO:0051302	regulation of cell division	BP
GO:0051303	establishment of chromosome localization	BP
GO:0051310	metaphase plate congression	BP
GO:0051311	meiotic metaphase plate congression	BP
GO:0051316	attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation	BP
GO:0051321	meiotic cell cycle	BP
GO:0051455	monopolar spindle attachment to meiosis I kinetochore	BP
GO:0051640	organelle localization	BP
GO:0051641	cellular localization	BP
GO:0051649	establishment of localization in cell	BP
GO:0051656	establishment of organelle localization	BP
GO:0051704	obsolete multi-organism process	BP
GO:0051716	cellular response to stimulus	BP
GO:0051726	regulation of cell cycle	BP
GO:0060249	anatomical structure homeostasis	BP
GO:0060255	regulation of macromolecule metabolic process	BP
GO:0060322	head development	BP
GO:0061458	reproductive system development	BP
GO:0061640	cytoskeleton-dependent cytokinesis	BP
GO:0061733	peptide-lysine-N-acetyltransferase activity	MF
GO:0061982	meiosis I cell cycle process	BP
GO:0065007	biological regulation	BP
GO:0065008	regulation of biological quality	BP
GO:0070013	intracellular organelle lumen	CC
GO:0070198	protein localization to chromosome, telomeric region	BP
GO:0070199	establishment of protein localization to chromosome	BP
GO:0070200	establishment of protein localization to telomere	BP
GO:0070727	cellular macromolecule localization	BP
GO:0071695	anatomical structure maturation	BP
GO:0071704	organic substance metabolic process	BP
GO:0071840	cellular component organization or biogenesis	BP
GO:0072331	signal transduction by p53 class mediator	BP
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	BP
GO:0072594	establishment of protein localization to organelle	BP
GO:0080090	regulation of primary metabolic process	BP
GO:0090304	nucleic acid metabolic process	BP
GO:0090329	regulation of DNA-templated DNA replication	BP
GO:0097159	organic cyclic compound binding	MF
GO:0097190	apoptotic signaling pathway	BP
GO:0097193	intrinsic apoptotic signaling pathway	BP
GO:0097708	intracellular vesicle	CC
GO:0098687	chromosomal region	CC
GO:0098813	nuclear chromosome segregation	BP
GO:0099086	synaptonemal structure	CC
GO:0099503	secretory vesicle	CC
GO:0140013	meiotic nuclear division	BP
GO:1901360	organic cyclic compound metabolic process	BP
GO:1901363	heterocyclic compound binding	MF
GO:1901564	organonitrogen compound metabolic process	BP
GO:1901576	organic substance biosynthetic process	BP
GO:1902298	cell cycle DNA replication maintenance of fidelity	BP
GO:1902680	positive regulation of RNA biosynthetic process	BP
GO:1902969	mitotic DNA replication	BP
GO:1903046	meiotic cell cycle process	BP
GO:1903047	mitotic cell cycle process	BP
GO:1903506	regulation of nucleic acid-templated transcription	BP
GO:1903508	positive regulation of nucleic acid-templated transcription	BP
GO:1990426	mitotic recombination-dependent replication fork processing	BP
GO:1990505	mitotic DNA replication maintenance of fidelity	BP
GO:2000026	regulation of multicellular organismal development	BP
GO:2000104	negative regulation of DNA-templated DNA replication	BP
GO:2000112	regulation of cellular macromolecule biosynthetic process	BP
GO:2000113	negative regulation of cellular macromolecule biosynthetic process	BP
GO:2001141	regulation of RNA biosynthetic process	BP

KEGG Term	Name	Description
map03440	Homologous recombination	Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.