PPGR - Gene Detail

Basic Information

Gene ID	JhiChr08G10326.g View in Genome Browser
Position	chr8:3042862-3050753 (-) 7891bp
Gene Type	gene
Gene Description (Protein Product)	DNA ligase
Organism	Juglans hindsii
Also AS	AT5G57160

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Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

JhiChr11G12565.g Double-strand break repair protein

JhiChr14G10158.g DNA replication ATP-dependent helicase nuclease

JhiChr13G10784.g Crossover junction endonuclease

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Pathway

GO Term	Description	GO Category
GO:0000726	obsolete non-recombinational repair	BP
GO:0003674	molecular_function	MF
GO:0003824	catalytic activity	MF
GO:0003909	DNA ligase activity	MF
GO:0003910	DNA ligase (ATP) activity	MF
GO:0005575	cellular_component	CC
GO:0005576	extracellular region	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005634	nucleus	CC
GO:0005737	cytoplasm	CC
GO:0005911	cell-cell junction	CC
GO:0006139	nucleobase-containing compound metabolic process	BP
GO:0006259	DNA metabolic process	BP
GO:0006266	DNA ligation	BP
GO:0006281	DNA repair	BP
GO:0006289	nucleotide-excision repair	BP
GO:0006297	nucleotide-excision repair, DNA gap filling	BP
GO:0006302	double-strand break repair	BP
GO:0006303	double-strand break repair via nonhomologous end joining	BP
GO:0006725	cellular aromatic compound metabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0006950	response to stress	BP
GO:0006974	cellular response to DNA damage stimulus	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0009314	response to radiation	BP
GO:0009506	plasmodesma	CC
GO:0009628	response to abiotic stimulus	BP
GO:0009987	cellular process	BP
GO:0010165	response to X-ray	BP
GO:0010212	response to ionizing radiation	BP
GO:0016874	ligase activity	MF
GO:0016886	ligase activity, forming phosphoric ester bonds	MF
GO:0030054	cell junction	CC
GO:0032807	DNA ligase IV complex	CC
GO:0032991	protein-containing complex	CC
GO:0033554	cellular response to stress	BP
GO:0034641	cellular nitrogen compound metabolic process	BP
GO:0043170	macromolecule metabolic process	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044422	obsolete organelle part	CC
GO:0044424	obsolete intracellular part	CC
GO:0044428	obsolete nuclear part	CC
GO:0044446	obsolete intracellular organelle part	CC
GO:0044464	obsolete cell part	CC
GO:0046483	heterocycle metabolic process	BP
GO:0048046	apoplast	CC
GO:0050896	response to stimulus	BP
GO:0051103	DNA ligation involved in DNA repair	BP
GO:0051716	cellular response to stimulus	BP
GO:0055044	symplast	CC
GO:0071704	organic substance metabolic process	BP
GO:0090304	nucleic acid metabolic process	BP
GO:0140097	catalytic activity, acting on DNA	MF
GO:1901360	organic cyclic compound metabolic process	BP

KEGG Term	Name	Description
map03450	Non-homologous end-joining	Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.