PPGR - Gene Detail

Basic Information

Gene Structure

Domain

Regulation&
Interaction

Annotation

Orthologus Group

Expresssion

Pathway

Basic Information

Gene ID	MD10G1110500.v1.1 View in Genome Browser
Position	Chr10:18186886-18187319 (-) 433bp
Gene Type	gene
Gene Description (Protein Product)	ER to Golgi vesicle-mediated transport
Organism	Malus domestica
Also AS	MD10G1110500AT2G47850

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)	MD13G1230500.v1.1 Protein transport protein Sec24-like MD15G1281700.v1.1 Protein transport protein Sec24-like MD16G1235300.v1.1 Protein transport protein Sec24-like
Regulatory gene	MD00G1020600.v1.1 B3 domain-containing MD00G1022000.v1.1 B3 domain-containing MD00G1022100.v1.1 B3 domain-containing

Load All Networks

Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Expression Profile

DataSet	Number of Samples expressed(TPM>1)	Mean	Min	Max	Standard deviation(SD)	Coeffcient variation(CV)

Select Expression

Pathway

GO Term	Description	GO Category
GO:0000122	negative regulation of transcription by RNA polymerase II	BP
GO:0000165	MAPK cascade	BP
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	BP
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	BP
GO:0000322	storage vacuole	CC
GO:0000323	lytic vacuole	CC
GO:0000324	fungal-type vacuole	CC
GO:0000329	fungal-type vacuole membrane	CC
GO:0000932	P-body	CC
GO:0000956	nuclear-transcribed mRNA catabolic process	BP
GO:0001817	regulation of cytokine production	BP
GO:0001818	negative regulation of cytokine production	BP
GO:0002237	response to molecule of bacterial origin	BP
GO:0002376	immune system process	BP
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	BP
GO:0002478	antigen processing and presentation of exogenous peptide antigen	BP
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	BP
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	BP
GO:0002682	regulation of immune system process	BP
GO:0002683	negative regulation of immune system process	BP
GO:0002791	regulation of peptide secretion	BP
GO:0002793	positive regulation of peptide secretion	BP
GO:0003674	molecular_function	MF
GO:0003676	nucleic acid binding	MF
GO:0003723	RNA binding	MF
GO:0003727	single-stranded RNA binding	MF
GO:0003729	mRNA binding	MF
GO:0003730	mRNA 3'-UTR binding	MF
GO:0005048	signal sequence binding	MF
GO:0005215	transporter activity	MF
GO:0005488	binding	MF
GO:0005515	protein binding	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005634	nucleus	CC
GO:0005737	cytoplasm	CC
GO:0005773	vacuole	CC
GO:0005774	vacuolar membrane	CC
GO:0005783	endoplasmic reticulum	CC
GO:0005789	endoplasmic reticulum membrane	CC
GO:0005798	Golgi-associated vesicle	CC
GO:0005829	cytosol	CC
GO:0006139	nucleobase-containing compound metabolic process	BP
GO:0006355	regulation of DNA-templated transcription	BP
GO:0006357	regulation of transcription by RNA polymerase II	BP
GO:0006401	RNA catabolic process	BP
GO:0006402	mRNA catabolic process	BP
GO:0006403	RNA localization	BP
GO:0006417	regulation of translation	BP
GO:0006464	protein modification process	BP
GO:0006468	protein phosphorylation	BP
GO:0006725	cellular aromatic compound metabolic process	BP
GO:0006793	phosphorus metabolic process	BP
GO:0006796	phosphate-containing compound metabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0006810	transport	BP
GO:0006886	intracellular protein transport	BP
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	BP
GO:0006900	vesicle budding from membrane	BP
GO:0006901	vesicle coating	BP
GO:0006903	vesicle targeting	BP
GO:0006914	autophagy	BP
GO:0006950	response to stress	BP
GO:0006996	organelle organization	BP
GO:0007154	cell communication	BP
GO:0007165	signal transduction	BP
GO:0008104	protein localization	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0008270	zinc ion binding	MF
GO:0009056	catabolic process	BP
GO:0009057	macromolecule catabolic process	BP
GO:0009605	response to external stimulus	BP
GO:0009607	response to biotic stimulus	BP
GO:0009611	response to wounding	BP
GO:0009617	response to bacterium	BP
GO:0009719	response to endogenous stimulus	BP
GO:0009725	response to hormone	BP
GO:0009889	regulation of biosynthetic process	BP
GO:0009890	negative regulation of biosynthetic process	BP
GO:0009892	negative regulation of metabolic process	BP
GO:0009893	positive regulation of metabolic process	BP
GO:0009894	regulation of catabolic process	BP
GO:0009895	negative regulation of catabolic process	BP
GO:0009896	positive regulation of catabolic process	BP
GO:0009987	cellular process	BP
GO:0009991	response to extracellular stimulus	BP
GO:0010033	response to organic substance	BP
GO:0010468	regulation of gene expression	BP
GO:0010494	cytoplasmic stress granule	CC
GO:0010556	regulation of macromolecule biosynthetic process	BP
GO:0010558	negative regulation of macromolecule biosynthetic process	BP
GO:0010604	positive regulation of macromolecule metabolic process	BP
GO:0010605	negative regulation of macromolecule metabolic process	BP
GO:0010608	post-transcriptional regulation of gene expression	BP
GO:0010628	positive regulation of gene expression	BP
GO:0010629	negative regulation of gene expression	BP
GO:0010837	regulation of keratinocyte proliferation	BP
GO:0010869	obsolete regulation of receptor biosynthetic process	BP
GO:0010941	regulation of cell death	BP
GO:0012505	endomembrane system	CC
GO:0012506	vesicle membrane	CC
GO:0012507	ER to Golgi transport vesicle membrane	CC
GO:0014070	response to organic cyclic compound	BP
GO:0015031	protein transport	BP
GO:0015833	peptide transport	BP
GO:0015931	nucleobase-containing compound transport	BP
GO:0016020	membrane	CC
GO:0016043	cellular component organization	BP
GO:0016050	vesicle organization	BP
GO:0016070	RNA metabolic process	BP
GO:0016071	mRNA metabolic process	BP
GO:0016192	vesicle-mediated transport	BP
GO:0016236	macroautophagy	BP
GO:0016310	phosphorylation	BP
GO:0016441	post-transcriptional gene silencing	BP
GO:0016458	obsolete gene silencing	BP
GO:0017091	mRNA 3'-UTR AU-rich region binding	MF
GO:0017148	negative regulation of translation	BP
GO:0019219	regulation of nucleobase-containing compound metabolic process	BP
GO:0019222	regulation of metabolic process	BP
GO:0019439	aromatic compound catabolic process	BP
GO:0019538	protein metabolic process	BP
GO:0019882	antigen processing and presentation	BP
GO:0019884	antigen processing and presentation of exogenous antigen	BP
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	BP
GO:0019899	enzyme binding	MF
GO:0019900	kinase binding	MF
GO:0019901	protein kinase binding	MF
GO:0019955	cytokine binding	MF
GO:0019956	chemokine binding	MF
GO:0019957	C-C chemokine binding	MF
GO:0022607	cellular component assembly	BP
GO:0023014	signal transduction	BP
GO:0023052	signaling	BP
GO:0030117	membrane coat	CC
GO:0030120	vesicle coat	CC
GO:0030127	COPII vesicle coat	CC
GO:0030133	transport vesicle	CC
GO:0030134	COPII-coated ER to Golgi transport vesicle	CC
GO:0030135	coated vesicle	CC
GO:0030658	transport vesicle membrane	CC
GO:0030659	cytoplasmic vesicle membrane	CC
GO:0030660	Golgi-associated vesicle membrane	CC
GO:0030662	coated vesicle membrane	CC
GO:0030856	regulation of epithelial cell differentiation	BP
GO:0031047	RNA-mediated gene silencing	BP
GO:0031072	heat shock protein binding	MF
GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	BP
GO:0031090	organelle membrane	CC
GO:0031098	stress-activated protein kinase signaling cascade	BP
GO:0031323	regulation of cellular metabolic process	BP
GO:0031324	negative regulation of cellular metabolic process	BP
GO:0031325	positive regulation of cellular metabolic process	BP
GO:0031326	regulation of cellular biosynthetic process	BP
GO:0031327	negative regulation of cellular biosynthetic process	BP
GO:0031329	regulation of cellular catabolic process	BP
GO:0031330	negative regulation of cellular catabolic process	BP
GO:0031331	positive regulation of cellular catabolic process	BP
GO:0031347	regulation of defense response	BP
GO:0031348	negative regulation of defense response	BP
GO:0031410	cytoplasmic vesicle	CC
GO:0031667	response to nutrient levels	BP
GO:0031960	response to corticosteroid	BP
GO:0031982	vesicle	CC
GO:0031984	organelle subcompartment	CC
GO:0032101	regulation of response to external stimulus	BP
GO:0032102	negative regulation of response to external stimulus	BP
GO:0032268	regulation of protein metabolic process	BP
GO:0032269	negative regulation of protein metabolic process	BP
GO:0032496	response to lipopolysaccharide	BP
GO:0032663	regulation of interleukin-2 production	BP
GO:0032680	regulation of tumor necrosis factor production	BP
GO:0032703	negative regulation of interleukin-2 production	BP
GO:0032870	cellular response to hormone stimulus	BP
GO:0032879	regulation of localization	BP
GO:0032880	regulation of protein localization	BP
GO:0032897	negative regulation of viral transcription	BP
GO:0032991	protein-containing complex	CC
GO:0033036	macromolecule localization	BP
GO:0033218	amide binding	MF
GO:0033554	cellular response to stress	BP
GO:0033993	response to lipid	BP
GO:0034097	response to cytokine	BP
GO:0034248	regulation of amide metabolic process	BP
GO:0034249	negative regulation of amide metabolic process	BP
GO:0034612	response to tumor necrosis factor	BP
GO:0034613	protein localization	BP
GO:0034622	protein-containing complex assembly	BP
GO:0034641	cellular nitrogen compound metabolic process	BP
GO:0034655	nucleobase-containing compound catabolic process	BP
GO:0035194	RNA-mediated post-transcriptional gene silencing	BP
GO:0035195	miRNA-mediated gene silencing	BP
GO:0035278	miRNA-mediated gene silencing by inhibition of translation	BP
GO:0035459	vesicle cargo loading	BP
GO:0035556	intracellular signal transduction	BP
GO:0035770	ribonucleoprotein granule	CC
GO:0035925	mRNA 3'-UTR AU-rich region binding	MF
GO:0036211	protein modification process	BP
GO:0036464	cytoplasmic ribonucleoprotein granule	CC
GO:0038066	p38MAPK cascade	BP
GO:0040029	epigenetic regulation of gene expression	BP
GO:0040033	sRNA-mediated gene silencing	BP
GO:0042035	regulation of cytokine production	BP
GO:0042036	negative regulation of cytokine production	BP
GO:0042127	regulation of cell population proliferation	BP
GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	CC
GO:0042221	response to chemical	BP
GO:0042277	peptide binding	MF
GO:0042592	homeostatic process	BP
GO:0042594	response to starvation	BP
GO:0042632	cholesterol homeostasis	BP
GO:0042886	amide transport	BP
GO:0042981	regulation of apoptotic process	BP
GO:0043067	regulation of programmed cell death	BP
GO:0043086	negative regulation of catalytic activity	BP
GO:0043167	ion binding	MF
GO:0043169	cation binding	MF
GO:0043170	macromolecule metabolic process	BP
GO:0043207	response to external biotic stimulus	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043228	non-membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0043232	intracellular non-membrane-bounded organelle	CC
GO:0043412	macromolecule modification	BP
GO:0043487	regulation of RNA stability	BP
GO:0043488	regulation of mRNA stability	BP
GO:0043489	RNA stabilization	BP
GO:0043900	obsolete regulation of multi-organism process	BP
GO:0043901	obsolete negative regulation of multi-organism process	BP
GO:0043903	regulation of biological process involved in symbiotic interaction	BP
GO:0043933	protein-containing complex organization	BP
GO:0044085	cellular component biogenesis	BP
GO:0044092	negative regulation of molecular function	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044248	cellular catabolic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044265	cellular macromolecule catabolic process	BP
GO:0044267	protein metabolic process	BP
GO:0044270	cellular nitrogen compound catabolic process	BP
GO:0044344	cellular response to fibroblast growth factor stimulus	BP
GO:0044422	obsolete organelle part	CC
GO:0044424	obsolete intracellular part	CC
GO:0044425	obsolete membrane part	CC
GO:0044432	obsolete endoplasmic reticulum part	CC
GO:0044433	obsolete cytoplasmic vesicle part	CC
GO:0044437	obsolete vacuolar part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044446	obsolete intracellular organelle part	CC
GO:0044464	obsolete cell part	CC
GO:0045076	regulation of interleukin-2 production	BP
GO:0045085	negative regulation of interleukin-2 production	BP
GO:0045184	establishment of protein localization	BP
GO:0045595	regulation of cell differentiation	BP
GO:0045596	negative regulation of cell differentiation	BP
GO:0045597	positive regulation of cell differentiation	BP
GO:0045598	regulation of fat cell differentiation	BP
GO:0045600	positive regulation of fat cell differentiation	BP
GO:0045604	regulation of epidermal cell differentiation	BP
GO:0045616	regulation of keratinocyte differentiation	BP
GO:0045637	regulation of myeloid cell differentiation	BP
GO:0045638	negative regulation of myeloid cell differentiation	BP
GO:0045646	regulation of erythrocyte differentiation	BP
GO:0045647	negative regulation of erythrocyte differentiation	BP
GO:0045682	regulation of epidermis development	BP
GO:0045714	obsolete regulation of low-density lipoprotein particle receptor biosynthetic process	BP
GO:0045892	negative regulation of DNA-templated transcription	BP
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	BP
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	BP
GO:0045974	regulation of translation, ncRNA-mediated	BP
GO:0046483	heterocycle metabolic process	BP
GO:0046700	heterocycle catabolic process	BP
GO:0046782	regulation of viral transcription	BP
GO:0046872	metal ion binding	MF
GO:0046907	intracellular transport	BP
GO:0046914	transition metal ion binding	MF
GO:0048002	antigen processing and presentation of peptide antigen	BP
GO:0048193	Golgi vesicle transport	BP
GO:0048194	Golgi vesicle budding	BP
GO:0048199	vesicle targeting, to, from or within Golgi	BP
GO:0048207	vesicle targeting, rough ER to cis-Golgi	BP
GO:0048208	COPII vesicle coating	BP
GO:0048255	mRNA stabilization	BP
GO:0048475	coated membrane	CC
GO:0048518	positive regulation of biological process	BP
GO:0048519	negative regulation of biological process	BP
GO:0048522	positive regulation of cellular process	BP
GO:0048523	negative regulation of cellular process	BP
GO:0048525	negative regulation of viral process	BP
GO:0048545	response to steroid hormone	BP
GO:0048583	regulation of response to stimulus	BP
GO:0048585	negative regulation of response to stimulus	BP
GO:0048878	chemical homeostasis	BP
GO:0050657	nucleic acid transport	BP
GO:0050658	RNA transport	BP
GO:0050678	regulation of epithelial cell proliferation	BP
GO:0050708	regulation of protein secretion	BP
GO:0050714	positive regulation of protein secretion	BP
GO:0050727	regulation of inflammatory response	BP
GO:0050728	negative regulation of inflammatory response	BP
GO:0050779	RNA destabilization	BP
GO:0050789	regulation of biological process	BP
GO:0050790	regulation of catalytic activity	BP
GO:0050792	regulation of viral process	BP
GO:0050793	regulation of developmental process	BP
GO:0050794	regulation of cellular process	BP
GO:0050896	response to stimulus	BP
GO:0051028	mRNA transport	BP
GO:0051046	regulation of secretion	BP
GO:0051047	positive regulation of secretion	BP
GO:0051049	regulation of transport	BP
GO:0051050	positive regulation of transport	BP
GO:0051093	negative regulation of developmental process	BP
GO:0051094	positive regulation of developmental process	BP
GO:0051171	regulation of nitrogen compound metabolic process	BP
GO:0051172	negative regulation of nitrogen compound metabolic process	BP
GO:0051173	positive regulation of nitrogen compound metabolic process	BP
GO:0051179	localization	BP
GO:0051222	positive regulation of protein transport	BP
GO:0051223	regulation of protein transport	BP
GO:0051234	establishment of localization	BP
GO:0051236	establishment of RNA localization	BP
GO:0051239	regulation of multicellular organismal process	BP
GO:0051241	negative regulation of multicellular organismal process	BP
GO:0051246	regulation of protein metabolic process	BP
GO:0051248	negative regulation of protein metabolic process	BP
GO:0051252	regulation of RNA metabolic process	BP
GO:0051253	negative regulation of RNA metabolic process	BP
GO:0051254	positive regulation of RNA metabolic process	BP
GO:0051338	regulation of transferase activity	BP
GO:0051348	negative regulation of transferase activity	BP
GO:0051384	response to glucocorticoid	BP
GO:0051403	stress-activated MAPK cascade	BP
GO:0051640	organelle localization	BP
GO:0051641	cellular localization	BP
GO:0051648	vesicle localization	BP
GO:0051649	establishment of localization in cell	BP
GO:0051650	establishment of vesicle localization	BP
GO:0051656	establishment of organelle localization	BP
GO:0051668	localization within membrane	BP
GO:0051704	obsolete multi-organism process	BP
GO:0051707	response to other organism	BP
GO:0051716	cellular response to stimulus	BP
GO:0055088	lipid homeostasis	BP
GO:0055092	sterol homeostasis	BP
GO:0060147	regulation of post-transcriptional gene silencing	BP
GO:0060148	positive regulation of post-transcriptional gene silencing	BP
GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening	BP
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	BP
GO:0060255	regulation of macromolecule metabolic process	BP
GO:0060341	regulation of cellular localization	BP
GO:0060964	regulation of miRNA-mediated gene silencing	BP
GO:0060966	regulation of gene silencing by RNA	BP
GO:0060968	obsolete regulation of gene silencing	BP
GO:0061013	regulation of mRNA catabolic process	BP
GO:0061014	positive regulation of mRNA catabolic process	BP
GO:0061024	membrane organization	BP
GO:0061157	mRNA destabilization	BP
GO:0061158	3'-UTR-mediated mRNA destabilization	BP
GO:0061919	process utilizing autophagic mechanism	BP
GO:0065003	protein-containing complex assembly	BP
GO:0065007	biological regulation	BP
GO:0065008	regulation of biological quality	BP
GO:0065009	regulation of molecular function	BP
GO:0070063	RNA polymerase binding	MF
GO:0070201	regulation of establishment of protein localization	BP
GO:0070727	cellular macromolecule localization	BP
GO:0070848	response to growth factor	BP
GO:0070849	response to epidermal growth factor	BP
GO:0070887	cellular response to chemical stimulus	BP
GO:0070935	3'-UTR-mediated mRNA stabilization	BP
GO:0070971	endoplasmic reticulum exit site	CC
GO:0071216	cellular response to biotic stimulus	BP
GO:0071219	cellular response to molecule of bacterial origin	BP
GO:0071222	cellular response to lipopolysaccharide	BP
GO:0071310	cellular response to organic substance	BP
GO:0071345	cellular response to cytokine stimulus	BP
GO:0071356	cellular response to tumor necrosis factor	BP
GO:0071363	cellular response to growth factor stimulus	BP
GO:0071364	cellular response to epidermal growth factor stimulus	BP
GO:0071383	cellular response to steroid hormone stimulus	BP
GO:0071384	cellular response to corticosteroid stimulus	BP
GO:0071385	cellular response to glucocorticoid stimulus	BP
GO:0071396	cellular response to lipid	BP
GO:0071407	cellular response to organic cyclic compound	BP
GO:0071495	cellular response to endogenous stimulus	BP
GO:0071702	organic substance transport	BP
GO:0071704	organic substance metabolic process	BP
GO:0071705	nitrogen compound transport	BP
GO:0071774	response to fibroblast growth factor	BP
GO:0071840	cellular component organization or biogenesis	BP
GO:0071889	14-3-3 protein binding	MF
GO:0080090	regulation of primary metabolic process	BP
GO:0080134	regulation of response to stress	BP
GO:0090087	regulation of peptide transport	BP
GO:0090110	COPII-coated vesicle cargo loading	BP
GO:0090114	COPII-coated vesicle budding	BP
GO:0090304	nucleic acid metabolic process	BP
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	BP
GO:0097012	response to granulocyte macrophage colony-stimulating factor	BP
GO:0097159	organic cyclic compound binding	MF
GO:0097708	intracellular vesicle	CC
GO:0098588	bounding membrane of organelle	CC
GO:0098796	membrane protein complex	CC
GO:0098805	membrane	CC
GO:0098827	endoplasmic reticulum subcompartment	CC
GO:0098852	lytic vacuole membrane	CC
GO:1900151	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	BP
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	BP
GO:1901360	organic cyclic compound metabolic process	BP
GO:1901361	organic cyclic compound catabolic process	BP
GO:1901363	heterocyclic compound binding	MF
GO:1901564	organonitrogen compound metabolic process	BP
GO:1901575	organic substance catabolic process	BP
GO:1901700	response to oxygen-containing compound	BP
GO:1901701	cellular response to oxygen-containing compound	BP
GO:1901834	regulation of deadenylation-independent decapping of nuclear-transcribed mRNA	BP
GO:1901835	positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA	BP
GO:1902172	regulation of keratinocyte apoptotic process	BP
GO:1902369	negative regulation of RNA catabolic process	BP
GO:1902373	negative regulation of mRNA catabolic process	BP
GO:1902679	negative regulation of RNA biosynthetic process	BP
GO:1903311	regulation of mRNA metabolic process	BP
GO:1903312	negative regulation of mRNA metabolic process	BP
GO:1903313	positive regulation of mRNA metabolic process	BP
GO:1903506	regulation of nucleic acid-templated transcription	BP
GO:1903507	negative regulation of nucleic acid-templated transcription	BP
GO:1903530	regulation of secretion by cell	BP
GO:1903532	positive regulation of secretion by cell	BP
GO:1903555	regulation of tumor necrosis factor superfamily cytokine production	BP
GO:1903706	regulation of hemopoiesis	BP
GO:1903707	negative regulation of hemopoiesis	BP
GO:1904035	regulation of epithelial cell apoptotic process	BP
GO:1904245	regulation of polynucleotide adenylyltransferase activity	BP
GO:1904246	negative regulation of polynucleotide adenylyltransferase activity	BP
GO:1904580	regulation of intracellular mRNA localization	BP
GO:1904582	positive regulation of intracellular mRNA localization	BP
GO:1904951	positive regulation of establishment of protein localization	BP
GO:1990904	ribonucleoprotein complex	CC
GO:2000026	regulation of multicellular organismal development	BP
GO:2000112	regulation of cellular macromolecule biosynthetic process	BP
GO:2000113	negative regulation of cellular macromolecule biosynthetic process	BP
GO:2000637	positive regulation of miRNA-mediated gene silencing	BP
GO:2001141	regulation of RNA biosynthetic process	BP

KEGG Term	Name	Description
map04141	Protein processing in endoplasmic reticulum	The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.