Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
Potra2n10c20794
View in Genome Browser
Position
chr10:4415876-4425850 (-)
9974bp
Gene Type
gene
Gene Description (Protein Product)
XH domain
Eukaryotic translation initiation factor 2
Organism
Populus tremula
Also AS Potri.010G184900Potri.008G072500Potri.010G184800AT2G40290AT3G48670Potri.010G184900.v4.1Potri.008G072500.v4.1Potri.010G184800.v4.1

Gene Structure

upstream:
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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
Potra2n13c25363 negative regulation of hemoglobin biosynthetic process
Potra2n13c25363 Eukaryotic translation initiation factor 2-alpha kinase
Potra2n13c25364 Protein tyrosine kinase
Regulatory gene
Potra2n10c20356 Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis
Potra2n10c20357 No apical meristem (NAM) protein
Potra2n10c20596 Dof zinc finger protein

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000075 cell cycle checkpoint signaling BP
GO:0000077 DNA damage checkpoint signaling BP
GO:0000278 mitotic cell cycle BP
GO:0002181 cytoplasmic translation BP
GO:0002183 cytoplasmic translational initiation BP
GO:0003674 molecular_function MF
GO:0003676 nucleic acid binding MF
GO:0003723 RNA binding MF
GO:0003729 mRNA binding MF
GO:0003743 translation initiation factor activity MF
GO:0005488 binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005737 cytoplasm CC
GO:0005829 cytosol CC
GO:0005840 ribosome CC
GO:0005850 eukaryotic translation initiation factor 2 complex CC
GO:0005851 eukaryotic translation initiation factor 2B complex CC
GO:0006412 translation BP
GO:0006413 translational initiation BP
GO:0006518 peptide metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0007049 cell cycle BP
GO:0007093 mitotic cell cycle checkpoint signaling BP
GO:0007346 regulation of mitotic cell cycle BP
GO:0008135 translation factor activity, RNA binding MF
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009987 cellular process BP
GO:0010467 gene expression BP
GO:0010564 regulation of cell cycle process BP
GO:0010948 negative regulation of cell cycle process BP
GO:0019538 protein metabolic process BP
GO:0022402 cell cycle process BP
GO:0031570 DNA integrity checkpoint signaling BP
GO:0031571 mitotic G1 DNA damage checkpoint signaling BP
GO:0032991 protein-containing complex CC
GO:0033290 eukaryotic 48S preinitiation complex CC
GO:0033554 cellular response to stress BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0043021 ribonucleoprotein complex binding MF
GO:0043022 ribosome binding MF
GO:0043043 peptide biosynthetic process BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043603 amide metabolic process BP
GO:0043604 amide biosynthetic process BP
GO:0043614 multi-eIF complex CC
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044267 protein metabolic process BP
GO:0044271 cellular nitrogen compound biosynthetic process BP
GO:0044424 obsolete intracellular part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044464 obsolete cell part CC
GO:0044773 mitotic DNA damage checkpoint signaling BP
GO:0044774 mitotic DNA integrity checkpoint signaling BP
GO:0044783 mitotic G1 DNA damage checkpoint signaling BP
GO:0044819 mitotic G1/S transition checkpoint signaling BP
GO:0044877 protein-containing complex binding MF
GO:0045786 negative regulation of cell cycle BP
GO:0045930 negative regulation of mitotic cell cycle BP
GO:0048519 negative regulation of biological process BP
GO:0048523 negative regulation of cellular process BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051716 cellular response to stimulus BP
GO:0051726 regulation of cell cycle BP
GO:0065007 biological regulation BP
GO:0070993 translation preinitiation complex CC
GO:0071704 organic substance metabolic process BP
GO:0097159 organic cyclic compound binding MF
GO:1901363 heterocyclic compound binding MF
GO:1901564 organonitrogen compound metabolic process BP
GO:1901566 organonitrogen compound biosynthetic process BP
GO:1901576 organic substance biosynthetic process BP
GO:1901987 regulation of cell cycle phase transition BP
GO:1901988 negative regulation of cell cycle phase transition BP
GO:1901990 regulation of mitotic cell cycle phase transition BP
GO:1901991 negative regulation of mitotic cell cycle phase transition BP
GO:1902806 regulation of cell cycle G1/S phase transition BP
GO:1902807 negative regulation of cell cycle G1/S phase transition BP
GO:1903047 mitotic cell cycle process BP
GO:1990904 ribonucleoprotein complex CC
GO:2000045 regulation of G1/S transition of mitotic cell cycle BP
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle BP
GO:0005655 nucleolar ribonuclease P complex CC
GO:0005730 nucleolus CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006304 DNA modification BP
GO:0006305 DNA alkylation BP
GO:0006306 DNA methylation BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0009892 negative regulation of metabolic process BP
GO:0010468 regulation of gene expression BP
GO:0010605 negative regulation of macromolecule metabolic process BP
GO:0010629 negative regulation of gene expression BP
GO:0016070 RNA metabolic process BP
GO:0016458 obsolete gene silencing BP
GO:0019222 regulation of metabolic process BP
GO:0030677 ribonuclease P complex CC
GO:0030681 multimeric ribonuclease P complex CC
GO:0031047 RNA-mediated gene silencing BP
GO:0031974 membrane-enclosed lumen CC
GO:0031981 nuclear lumen CC
GO:0032259 methylation BP
GO:0043233 organelle lumen CC
GO:0043412 macromolecule modification BP
GO:0043414 macromolecule methylation BP
GO:0044422 obsolete organelle part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044452 obsolete nucleolar part CC
GO:0044728 obsolete DNA methylation or demethylation BP
GO:0046483 heterocycle metabolic process BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0070013 intracellular organelle lumen CC
GO:0080188 gene silencing by RNA-directed DNA methylation BP
GO:0090304 nucleic acid metabolic process BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1902494 catalytic complex CC
GO:1902555 endoribonuclease complex CC
GO:1905348 endonuclease complex CC
KEGG Term Name Description
map04141 Protein processing in endoplasmic reticulum The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.