Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Expresssion
Pathway
Basic Information
Gene ID
PSME_31782.g
Position
jcf7190000051017:14598-15589 (-)
991bp
Gene Type
gene
Gene Description (Protein Product)
"Catalytic subunit of the molybdopterin synthase complex
Organism
Pseudotsuga menziesii
Also AS AT2G43760

Gene Structure

upstream:
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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
PSME_44879.g Molybdopterin biosynthesis protein
PSME_40438.g Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form
PSME_34005.g Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor
Regulatory gene
PSME_00050.g ethylene-responsive transcription factor
PSME_00087.g ethylene-responsive transcription factor
PSME_00128.g ethylene-responsive transcription factor

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005737 cytoplasm CC
GO:0005829 cytosol CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006163 purine nucleotide metabolic process BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006732 obsolete coenzyme metabolic process BP
GO:0006753 nucleoside phosphate metabolic process BP
GO:0006793 phosphorus metabolic process BP
GO:0006796 phosphate-containing compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009058 biosynthetic process BP
GO:0009116 nucleoside metabolic process BP
GO:0009117 nucleotide metabolic process BP
GO:0009119 ribonucleoside metabolic process BP
GO:0009141 nucleoside triphosphate metabolic process BP
GO:0009144 purine nucleoside triphosphate metabolic process BP
GO:0009150 purine ribonucleotide metabolic process BP
GO:0009199 ribonucleoside triphosphate metabolic process BP
GO:0009205 purine ribonucleoside triphosphate metabolic process BP
GO:0009259 ribonucleotide metabolic process BP
GO:0009987 cellular process BP
GO:0016740 transferase activity MF
GO:0016782 transferase activity, transferring sulphur-containing groups MF
GO:0016783 sulfurtransferase activity MF
GO:0018130 heterocycle biosynthetic process BP
GO:0019538 protein metabolic process BP
GO:0019637 organophosphate metabolic process BP
GO:0019693 ribose phosphate metabolic process BP
GO:0030366 molybdopterin synthase activity MF
GO:0032324 molybdopterin cofactor biosynthetic process BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0042278 purine nucleoside metabolic process BP
GO:0043170 macromolecule metabolic process BP
GO:0043545 molybdopterin cofactor metabolic process BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044267 protein metabolic process BP
GO:0044281 small molecule metabolic process BP
GO:0044424 obsolete intracellular part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044464 obsolete cell part CC
GO:0046039 GTP metabolic process BP
GO:0046128 purine ribonucleoside metabolic process BP
GO:0046483 heterocycle metabolic process BP
GO:0051186 obsolete cofactor metabolic process BP
GO:0051188 obsolete cofactor biosynthetic process BP
GO:0051189 prosthetic group metabolic process BP
GO:0055086 nucleobase-containing small molecule metabolic process BP
GO:0071704 organic substance metabolic process BP
GO:0072521 purine-containing compound metabolic process BP
GO:0090407 organophosphate biosynthetic process BP
GO:1901068 guanosine-containing compound metabolic process BP
GO:1901135 carbohydrate derivative metabolic process BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1901362 organic cyclic compound biosynthetic process BP
GO:1901564 organonitrogen compound metabolic process BP
GO:1901566 organonitrogen compound biosynthetic process BP
GO:1901576 organic substance biosynthetic process BP
GO:1901657 glycosyl compound metabolic process BP
KEGG Term Name Description
map04122 Sulfur relay system Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein modification evolved from prokaryotic sulfurtransfer systems. Molybdenum cofactor (Moco) and thiamin are sulfur-containing cofactors whose biosynthesis includes a key sulfur transfer step that uses unique sulfur carrier proteins, MoaD and ThiS. Ubiquitin, MoaD, and ThiS are all structurally related proteins whose C-termini are activated through adenylation by homologous E1-like enzymes. s2T biosynthesis may share similar chemistry with Moco and thiamin synthesis. In Saccharomyces cerevisiae, Urm1 and Uba4 function as part of a ubl protein conjugation system, though they have sequence homology to bacterial sulfur-transfer enzymes and the ability to function in sulfur transfer.
map01100 Metabolic pathways -
map00790 Folate biosynthesis -