PPGR - Gene Detail

Basic Information

Gene Structure

Domain

Regulation&
Interaction

Annotation

Orthologus Group

Pathway

Basic Information

Gene ID	gene-IMY05_C4432000700 View in Genome Browser
Position	JAEQKX010000655.1:20606-22857 (+) 2251bp
Gene Type	gene
Gene Description (Protein Product)	repair protein
Organism	Salix suchowensis
Also AS	AT2G31970

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Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

gene-IMY05_C4465000300 Telomere-length maintenance and DNA damage repair

gene-IMY05_C4891000100 four-way junction helicase activity

gene-IMY05_C4534000200 Structural maintenance of chromosomes protein

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Pathway

GO Term	Description	GO Category
GO:0000003	reproduction	BP
GO:0000018	regulation of DNA recombination	BP
GO:0000075	cell cycle checkpoint signaling	BP
GO:0000077	DNA damage checkpoint signaling	BP
GO:0000166	nucleotide binding	MF
GO:0000228	nuclear chromosome	CC
GO:0000278	mitotic cell cycle	BP
GO:0000280	nuclear division	BP
GO:0000706	meiotic DNA double-strand break processing	BP
GO:0000722	telomere maintenance via recombination	BP
GO:0000723	telomere maintenance	BP
GO:0000724	double-strand break repair via homologous recombination	BP
GO:0000725	recombinational repair	BP
GO:0000726	obsolete non-recombinational repair	BP
GO:0000727	double-strand break repair via break-induced replication	BP
GO:0000729	DNA double-strand break processing	BP
GO:0000781	chromosome, telomeric region	CC
GO:0000784	chromosome, telomeric region	CC
GO:0000785	chromatin	CC
GO:0000790	chromatin	CC
GO:0000793	condensed chromosome	CC
GO:0000794	condensed nuclear chromosome	CC
GO:0003674	molecular_function	MF
GO:0003676	nucleic acid binding	MF
GO:0003677	DNA binding	MF
GO:0003678	DNA helicase activity	MF
GO:0003690	double-stranded DNA binding	MF
GO:0003691	double-stranded telomeric DNA binding	MF
GO:0003697	single-stranded DNA binding	MF
GO:0003824	catalytic activity	MF
GO:0004003	DNA helicase activity	MF
GO:0004017	adenylate kinase activity	MF
GO:0004386	helicase activity	MF
GO:0005488	binding	MF
GO:0005524	ATP binding	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005634	nucleus	CC
GO:0005694	chromosome	CC
GO:0005737	cytoplasm	CC
GO:0005739	mitochondrion	CC
GO:0006139	nucleobase-containing compound metabolic process	BP
GO:0006259	DNA metabolic process	BP
GO:0006260	DNA replication	BP
GO:0006261	DNA-templated DNA replication	BP
GO:0006278	RNA-templated DNA biosynthetic process	BP
GO:0006281	DNA repair	BP
GO:0006284	base-excision repair	BP
GO:0006302	double-strand break repair	BP
GO:0006303	double-strand break repair via nonhomologous end joining	BP
GO:0006310	DNA recombination	BP
GO:0006312	mitotic recombination	BP
GO:0006725	cellular aromatic compound metabolic process	BP
GO:0006753	nucleoside phosphate metabolic process	BP
GO:0006793	phosphorus metabolic process	BP
GO:0006796	phosphate-containing compound metabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0006950	response to stress	BP
GO:0006974	cellular response to DNA damage stimulus	BP
GO:0006996	organelle organization	BP
GO:0007004	telomere maintenance via telomerase	BP
GO:0007049	cell cycle	BP
GO:0007093	mitotic cell cycle checkpoint signaling	BP
GO:0007127	meiosis I	BP
GO:0007131	reciprocal meiotic recombination	BP
GO:0007154	cell communication	BP
GO:0007165	signal transduction	BP
GO:0007346	regulation of mitotic cell cycle	BP
GO:0008026	helicase activity	MF
GO:0008094	ATP-dependent activity, acting on DNA	MF
GO:0008144	obsolete drug binding	MF
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0009058	biosynthetic process	BP
GO:0009059	macromolecule biosynthetic process	BP
GO:0009117	nucleotide metabolic process	BP
GO:0009123	nucleoside monophosphate metabolic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0009892	negative regulation of metabolic process	BP
GO:0009987	cellular process	BP
GO:0010520	regulation of reciprocal meiotic recombination	BP
GO:0010564	regulation of cell cycle process	BP
GO:0010605	negative regulation of macromolecule metabolic process	BP
GO:0010705	meiotic DNA double-strand break processing involved in reciprocal meiotic recombination	BP
GO:0010833	telomere maintenance via telomere lengthening	BP
GO:0016043	cellular component organization	BP
GO:0016233	telomere capping	BP
GO:0016301	kinase activity	MF
GO:0016310	phosphorylation	BP
GO:0016462	pyrophosphatase activity	MF
GO:0016740	transferase activity	MF
GO:0016772	transferase activity, transferring phosphorus-containing groups	MF
GO:0016776	phosphotransferase activity, phosphate group as acceptor	MF
GO:0016787	hydrolase activity	MF
GO:0016817	hydrolase activity, acting on acid anhydrides	MF
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	MF
GO:0016887	ATP hydrolysis activity	MF
GO:0017076	purine nucleotide binding	MF
GO:0017111	ribonucleoside triphosphate phosphatase activity	MF
GO:0018130	heterocycle biosynthetic process	BP
GO:0019205	nucleobase-containing compound kinase activity	MF
GO:0019219	regulation of nucleobase-containing compound metabolic process	BP
GO:0019222	regulation of metabolic process	BP
GO:0019438	aromatic compound biosynthetic process	BP
GO:0019637	organophosphate metabolic process	BP
GO:0022402	cell cycle process	BP
GO:0022414	reproductive process	BP
GO:0023052	signaling	BP
GO:0030554	adenyl nucleotide binding	MF
GO:0030870	Mre11 complex	CC
GO:0031297	replication fork processing	BP
GO:0031323	regulation of cellular metabolic process	BP
GO:0031324	negative regulation of cellular metabolic process	BP
GO:0031570	DNA integrity checkpoint signaling	BP
GO:0031573	mitotic intra-S DNA damage checkpoint signaling	BP
GO:0031974	membrane-enclosed lumen	CC
GO:0031981	nuclear lumen	CC
GO:0032069	regulation of nuclease activity	BP
GO:0032070	regulation of deoxyribonuclease activity	BP
GO:0032071	regulation of endodeoxyribonuclease activity	BP
GO:0032074	negative regulation of nuclease activity	BP
GO:0032076	negative regulation of deoxyribonuclease activity	BP
GO:0032078	negative regulation of endodeoxyribonuclease activity	BP
GO:0032200	telomere organization	BP
GO:0032392	DNA geometric change	BP
GO:0032508	DNA duplex unwinding	BP
GO:0032553	ribonucleotide binding	MF
GO:0032555	purine ribonucleotide binding	MF
GO:0032559	adenyl ribonucleotide binding	MF
GO:0032991	protein-containing complex	CC
GO:0033043	regulation of organelle organization	BP
GO:0033260	nuclear DNA replication	BP
GO:0033554	cellular response to stress	BP
GO:0034641	cellular nitrogen compound metabolic process	BP
GO:0034645	cellular macromolecule biosynthetic process	BP
GO:0034654	nucleobase-containing compound biosynthetic process	BP
GO:0035556	intracellular signal transduction	BP
GO:0035639	purine ribonucleoside triphosphate binding	MF
GO:0035753	maintenance of DNA trinucleotide repeats	BP
GO:0035825	homologous recombination	BP
GO:0035861	site of double-strand break	CC
GO:0036094	small molecule binding	MF
GO:0040020	regulation of meiotic nuclear division	BP
GO:0042138	meiotic DNA double-strand break formation	BP
GO:0042162	telomeric DNA binding	MF
GO:0042592	homeostatic process	BP
GO:0042623	ATP hydrolysis activity	MF
GO:0042769	obsolete DNA damage response, detection of DNA damage	BP
GO:0042770	signal transduction in response to DNA damage	BP
GO:0043047	single-stranded telomeric DNA binding	MF
GO:0043086	negative regulation of catalytic activity	BP
GO:0043167	ion binding	MF
GO:0043168	anion binding	MF
GO:0043170	macromolecule metabolic process	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043228	non-membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0043232	intracellular non-membrane-bounded organelle	CC
GO:0043233	organelle lumen	CC
GO:0043565	sequence-specific DNA binding	MF
GO:0043570	maintenance of DNA repeat elements	BP
GO:0044092	negative regulation of molecular function	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044249	cellular biosynthetic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044271	cellular nitrogen compound biosynthetic process	BP
GO:0044281	small molecule metabolic process	BP
GO:0044422	obsolete organelle part	CC
GO:0044424	obsolete intracellular part	CC
GO:0044427	obsolete chromosomal part	CC
GO:0044428	obsolete nuclear part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044446	obsolete intracellular organelle part	CC
GO:0044454	obsolete nuclear chromosome part	CC
GO:0044464	obsolete cell part	CC
GO:0044773	mitotic DNA damage checkpoint signaling	BP
GO:0044774	mitotic DNA integrity checkpoint signaling	BP
GO:0044786	cell cycle DNA replication	BP
GO:0045005	DNA-templated DNA replication maintenance of fidelity	BP
GO:0045786	negative regulation of cell cycle	BP
GO:0045930	negative regulation of mitotic cell cycle	BP
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	BP
GO:0046483	heterocycle metabolic process	BP
GO:0046940	nucleoside monophosphate phosphorylation	BP
GO:0048285	organelle fission	BP
GO:0048519	negative regulation of biological process	BP
GO:0048523	negative regulation of cellular process	BP
GO:0050145	nucleoside monophosphate kinase activity	MF
GO:0050789	regulation of biological process	BP
GO:0050790	regulation of catalytic activity	BP
GO:0050794	regulation of cellular process	BP
GO:0050896	response to stimulus	BP
GO:0051052	regulation of DNA metabolic process	BP
GO:0051053	negative regulation of DNA metabolic process	BP
GO:0051128	regulation of cellular component organization	BP
GO:0051171	regulation of nitrogen compound metabolic process	BP
GO:0051172	negative regulation of nitrogen compound metabolic process	BP
GO:0051276	chromosome organization	BP
GO:0051321	meiotic cell cycle	BP
GO:0051336	regulation of hydrolase activity	BP
GO:0051346	negative regulation of hydrolase activity	BP
GO:0051445	regulation of meiotic cell cycle	BP
GO:0051606	detection of stimulus	BP
GO:0051716	cellular response to stimulus	BP
GO:0051726	regulation of cell cycle	BP
GO:0051783	regulation of nuclear division	BP
GO:0051880	G-quadruplex DNA binding	MF
GO:0055086	nucleobase-containing small molecule metabolic process	BP
GO:0060249	anatomical structure homeostasis	BP
GO:0060255	regulation of macromolecule metabolic process	BP
GO:0060631	regulation of meiosis I	BP
GO:0061982	meiosis I cell cycle process	BP
GO:0065007	biological regulation	BP
GO:0065008	regulation of biological quality	BP
GO:0065009	regulation of molecular function	BP
GO:0070013	intracellular organelle lumen	CC
GO:0070035	obsolete purine NTP-dependent helicase activity	MF
GO:0070192	chromosome organization involved in meiotic cell cycle	BP
GO:0071103	DNA conformation change	BP
GO:0071704	organic substance metabolic process	BP
GO:0071840	cellular component organization or biogenesis	BP
GO:0071897	DNA biosynthetic process	BP
GO:0072395	cell cycle checkpoint signaling	BP
GO:0072401	DNA integrity checkpoint signaling	BP
GO:0072422	DNA damage checkpoint signaling	BP
GO:0080090	regulation of primary metabolic process	BP
GO:0090304	nucleic acid metabolic process	BP
GO:0090305	nucleic acid phosphodiester bond hydrolysis	BP
GO:0090407	organophosphate biosynthetic process	BP
GO:0090734	site of DNA damage	CC
GO:0097159	organic cyclic compound binding	MF
GO:0097367	carbohydrate derivative binding	MF
GO:0097551	mitochondrial double-strand break repair	BP
GO:0097552	mitochondrial double-strand break repair via homologous recombination	BP
GO:0098687	chromosomal region	CC
GO:0098847	sequence-specific single stranded DNA binding	MF
GO:0110025	DNA strand resection involved in replication fork processing	BP
GO:0140013	meiotic nuclear division	BP
GO:0140097	catalytic activity, acting on DNA	MF
GO:1901265	nucleoside phosphate binding	MF
GO:1901293	nucleoside phosphate biosynthetic process	BP
GO:1901360	organic cyclic compound metabolic process	BP
GO:1901362	organic cyclic compound biosynthetic process	BP
GO:1901363	heterocyclic compound binding	MF
GO:1901576	organic substance biosynthetic process	BP
GO:1902298	cell cycle DNA replication maintenance of fidelity	BP
GO:1902969	mitotic DNA replication	BP
GO:1903046	meiotic cell cycle process	BP
GO:1903047	mitotic cell cycle process	BP
GO:1903211	mitotic recombination-dependent replication fork processing	BP
GO:1990426	mitotic recombination-dependent replication fork processing	BP
GO:1990505	mitotic DNA replication maintenance of fidelity	BP
GO:1990898	meiotic DNA double-strand break clipping	BP
GO:1990918	double-strand break repair involved in meiotic recombination	BP
GO:2000241	regulation of reproductive process	BP

KEGG Term	Name	Description
map03450	Non-homologous end-joining	Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
map03440	Homologous recombination	Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.