Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
gene-IMY05_C4488000100
View in Genome Browser
Position
JAEQKX010000698.1:1601-8769 (-)
7168bp
Gene Type
gene
Gene Description (Protein Product)
DNA polymerase
Organism
Salix suchowensis
Also AS AT5G63960

Gene Structure

upstream:
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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
gene-IMY05_C4608000400 MCM OB domain
gene-IMY05_C4891000100 four-way junction helicase activity
gene-IMY05_C4755000600 STAG domain

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000228 nuclear chromosome CC
GO:0000278 mitotic cell cycle BP
GO:0000731 DNA synthesis involved in DNA repair BP
GO:0000781 chromosome, telomeric region CC
GO:0000784 chromosome, telomeric region CC
GO:0003674 molecular_function MF
GO:0003676 nucleic acid binding MF
GO:0003677 DNA binding MF
GO:0003824 catalytic activity MF
GO:0003887 DNA-directed DNA polymerase activity MF
GO:0004518 nuclease activity MF
GO:0004527 exonuclease activity MF
GO:0004529 DNA exonuclease activity MF
GO:0004536 deoxyribonuclease activity MF
GO:0005488 binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005657 replication fork CC
GO:0005694 chromosome CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006260 DNA replication BP
GO:0006261 DNA-templated DNA replication BP
GO:0006271 DNA strand elongation involved in DNA replication BP
GO:0006273 lagging strand elongation BP
GO:0006278 RNA-templated DNA biosynthetic process BP
GO:0006281 DNA repair BP
GO:0006284 base-excision repair BP
GO:0006287 base-excision repair, gap-filling BP
GO:0006289 nucleotide-excision repair BP
GO:0006297 nucleotide-excision repair, DNA gap filling BP
GO:0006401 RNA catabolic process BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0007049 cell cycle BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008296 3'-5'-DNA exonuclease activity MF
GO:0008408 3'-5' exonuclease activity MF
GO:0009056 catabolic process BP
GO:0009057 macromolecule catabolic process BP
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009314 response to radiation BP
GO:0009411 response to UV BP
GO:0009416 response to light stimulus BP
GO:0009628 response to abiotic stimulus BP
GO:0009987 cellular process BP
GO:0016070 RNA metabolic process BP
GO:0016740 transferase activity MF
GO:0016772 transferase activity, transferring phosphorus-containing groups MF
GO:0016779 nucleotidyltransferase activity MF
GO:0016787 hydrolase activity MF
GO:0016788 hydrolase activity, acting on ester bonds MF
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters MF
GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters MF
GO:0018130 heterocycle biosynthetic process BP
GO:0019438 aromatic compound biosynthetic process BP
GO:0019439 aromatic compound catabolic process BP
GO:0022402 cell cycle process BP
GO:0022616 DNA strand elongation BP
GO:0030894 replisome CC
GO:0031974 membrane-enclosed lumen CC
GO:0031981 nuclear lumen CC
GO:0032991 protein-containing complex CC
GO:0032993 protein-DNA complex CC
GO:0033260 nuclear DNA replication BP
GO:0033554 cellular response to stress BP
GO:0033567 DNA replication, Okazaki fragment processing BP
GO:0034061 DNA polymerase activity MF
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034644 cellular response to UV BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0034654 nucleobase-containing compound biosynthetic process BP
GO:0034655 nucleobase-containing compound catabolic process BP
GO:0042575 DNA polymerase complex CC
GO:0043137 DNA replication, removal of RNA primer BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0043596 nuclear replication fork CC
GO:0043601 nuclear replisome CC
GO:0043625 delta DNA polymerase complex CC
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044248 cellular catabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044265 cellular macromolecule catabolic process BP
GO:0044270 cellular nitrogen compound catabolic process BP
GO:0044271 cellular nitrogen compound biosynthetic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044427 obsolete chromosomal part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044454 obsolete nuclear chromosome part CC
GO:0044464 obsolete cell part CC
GO:0044786 cell cycle DNA replication BP
GO:0045004 DNA replication proofreading BP
GO:0045005 DNA-templated DNA replication maintenance of fidelity BP
GO:0046483 heterocycle metabolic process BP
GO:0046700 heterocycle catabolic process BP
GO:0050896 response to stimulus BP
GO:0051716 cellular response to stimulus BP
GO:0061695 transferase complex, transferring phosphorus-containing groups CC
GO:0070013 intracellular organelle lumen CC
GO:0070914 UV-damage excision repair BP
GO:0071214 cellular response to abiotic stimulus BP
GO:0071478 cellular response to radiation BP
GO:0071482 cellular response to light stimulus BP
GO:0071704 organic substance metabolic process BP
GO:0071897 DNA biosynthetic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0090305 nucleic acid phosphodiester bond hydrolysis BP
GO:0097159 organic cyclic compound binding MF
GO:0098687 chromosomal region CC
GO:0104004 cellular response to environmental stimulus BP
GO:0140097 catalytic activity, acting on DNA MF
GO:1901360 organic cyclic compound metabolic process BP
GO:1901361 organic cyclic compound catabolic process BP
GO:1901362 organic cyclic compound biosynthetic process BP
GO:1901363 heterocyclic compound binding MF
GO:1901575 organic substance catabolic process BP
GO:1901576 organic substance biosynthetic process BP
GO:1902296 DNA strand elongation involved in cell cycle DNA replication BP
GO:1902319 DNA strand elongation involved in nuclear cell cycle DNA replication BP
GO:1902494 catalytic complex CC
GO:1902969 mitotic DNA replication BP
GO:1902983 DNA strand elongation involved in mitotic DNA replication BP
GO:1903047 mitotic cell cycle process BP
GO:1903459 mitotic DNA replication lagging strand elongation BP
GO:1904161 DNA synthesis involved in UV-damage excision repair BP
GO:1990234 transferase complex CC
KEGG Term Name Description
map03440 Homologous recombination Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
map03430 Mismatch repair DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
map03420 Nucleotide excision repair Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
map03410 Base excision repair Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
map03030 DNA replication A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.