Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
gene-IMY05_C4583000500
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Position
JAEQKX010000783.1:25433-26547 (+)
1114bp
Gene Type
gene
Gene Description (Protein Product)
Ubiquitin elongating factor core
Organism
Salix suchowensis
Also AS AT5G15400

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
gene-IMY05_C4876000300 Anaphase-promoting complex subunit 11 RING-H2 finger
gene-IMY05_C4695000200 Cullin-domain-containing protein
gene-IMY05_C4607000600 ubiquitin activating enzyme

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000209 protein polyubiquitination BP
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0004842 ubiquitin-protein transferase activity MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005737 cytoplasm CC
GO:0006464 protein modification process BP
GO:0006508 proteolysis BP
GO:0006511 ubiquitin-dependent protein catabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009056 catabolic process BP
GO:0009057 macromolecule catabolic process BP
GO:0009636 response to toxic substance BP
GO:0009893 positive regulation of metabolic process BP
GO:0009987 cellular process BP
GO:0010033 response to organic substance BP
GO:0010243 response to organonitrogen compound BP
GO:0010498 proteasomal protein catabolic process BP
GO:0010604 positive regulation of macromolecule metabolic process BP
GO:0016567 protein ubiquitination BP
GO:0016740 transferase activity MF
GO:0019222 regulation of metabolic process BP
GO:0019538 protein metabolic process BP
GO:0019787 ubiquitin-like protein transferase activity MF
GO:0019941 modification-dependent protein catabolic process BP
GO:0030163 protein catabolic process BP
GO:0030433 ubiquitin-dependent ERAD pathway BP
GO:0031323 regulation of cellular metabolic process BP
GO:0031325 positive regulation of cellular metabolic process BP
GO:0031396 regulation of protein ubiquitination BP
GO:0031398 positive regulation of protein ubiquitination BP
GO:0031399 regulation of protein modification process BP
GO:0031401 positive regulation of protein modification process BP
GO:0032268 regulation of protein metabolic process BP
GO:0032270 positive regulation of protein metabolic process BP
GO:0032446 protein modification by small protein conjugation BP
GO:0033554 cellular response to stress BP
GO:0034450 ubiquitin-ubiquitin ligase activity MF
GO:0034976 response to endoplasmic reticulum stress BP
GO:0035690 cellular response to xenobiotic stimulus BP
GO:0036211 protein modification process BP
GO:0036503 ERAD pathway BP
GO:0042221 response to chemical BP
GO:0042493 response to xenobiotic stimulus BP
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043412 macromolecule modification BP
GO:0043632 modification-dependent macromolecule catabolic process BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044248 cellular catabolic process BP
GO:0044257 protein catabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044265 cellular macromolecule catabolic process BP
GO:0044267 protein metabolic process BP
GO:0044424 obsolete intracellular part CC
GO:0044464 obsolete cell part CC
GO:0045471 response to ethanol BP
GO:0046677 response to antibiotic BP
GO:0048518 positive regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051173 positive regulation of nitrogen compound metabolic process BP
GO:0051246 regulation of protein metabolic process BP
GO:0051247 positive regulation of protein metabolic process BP
GO:0051603 proteolysis involved in protein catabolic process BP
GO:0051716 cellular response to stimulus BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0061630 ubiquitin protein ligase activity MF
GO:0061659 ubiquitin-like protein ligase activity MF
GO:0065007 biological regulation BP
GO:0070647 protein modification by small protein conjugation or removal BP
GO:0070887 cellular response to chemical stimulus BP
GO:0071236 cellular response to antibiotic BP
GO:0071310 cellular response to organic substance BP
GO:0071361 cellular response to ethanol BP
GO:0071704 organic substance metabolic process BP
GO:0080090 regulation of primary metabolic process BP
GO:0097237 cellular response to toxic substance BP
GO:0097305 response to alcohol BP
GO:0097306 cellular response to alcohol BP
GO:0140096 catalytic activity, acting on a protein MF
GO:1901564 organonitrogen compound metabolic process BP
GO:1901565 organonitrogen compound catabolic process BP
GO:1901575 organic substance catabolic process BP
GO:1901698 response to nitrogen compound BP
GO:1901700 response to oxygen-containing compound BP
GO:1901701 cellular response to oxygen-containing compound BP
GO:1903320 regulation of protein modification by small protein conjugation or removal BP
GO:1903322 positive regulation of protein modification by small protein conjugation or removal BP
KEGG Term Name Description
map04141 Protein processing in endoplasmic reticulum The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
map04120 Ubiquitin mediated proteolysis Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.