EDK Editome Disease Knowledgebase

Atherosclerosis is a disease in which the inside of an artery narrows due to the build of plaque. Initially there are generally no symptoms. When severe it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems depending on the arteries which are affected. Symptoms, if they occur, generally do not begin until middle age.

A liver carcinoma that has material basis in undifferentiated hepatocytes.

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A carcinoma that derives from squamous epithelial cells.

Basal-cell carcinoma, is the most common type of skin cancer. It often appears as a painless raised area of skin, which may be shiny with small blood vessels running over it; or it may present as a raised area with ulceration.

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Also known as Kennedy's disease (KD), is a debilitating neurodegenerative disorder resulting in muscle cramps and progressive weakness due to degeneration of motor neurons in the brain stem and spinal cord.

Epilepsy is a group of neurological disorders characterized by epileptic seizures. Epileptic seizures are episodes that can vary from brief and nearly undetectable periods to long periods of vigorous shaking. These episodes can result in physical injuries, including occasionally broken bones.

Huntington's disease, also known as Huntington's chorea, is an inherited disorder that results in death of brain cells.

A central nervous system disease that results in the progressive deterioration of function or structure of neurons.

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Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.

Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).

A synucleinopathy that has material basis in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.

A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel.

Bladder Carcinoma is any of several types of cancer arising from the tissues of the urinary bladder. It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body.

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A male reproductive organ cancer that is located in the prostate.

A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.

Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin.

A cell type cancer that has material basis in abnormally proliferating cells derived from melanocytes which are found in skin, the bowel and the eye.

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A glioma is a type of tumor that starts in the glial cells of the brain or the spine. Gliomas comprise about 30 per cent of all brain tumors and central nervous system tumors, and 80 per cent of all malignant brain tumors.

Chronic myelogenous leukemia (CML) is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood.

A carcinoma that has material basis in abnormally proliferating cells, derives from epithelial cells, which originate in glandular tissue.

Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells, star-shaped brain cells in the cerebrum called astrocytes. This type of tumor does not usually spread outside the brain and spinal cord and it does not usually affect other organs. Astrocytomas are the most common glioma and can occur in most parts of the brain and occasionally in the spinal cord.

An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derives from multiple cell types including astrocytes and oligondroctyes.

Hepatitis is inflammation of the liver tissue. Some people have no symptoms whereas others develop yellow discoloration of the skin and whites of the eyes, poor appetite, vomiting, tiredness, abdominal pain, or diarrhea.

A renal carcinoma that has material basis in the lining of the proximal convoluted renal tubule of the kidney.

Head and neck cancer is a group of cancers that starts in the mouth, nose, throat, larynx, sinuses, or salivary glands.

Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb). It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body.

An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Ebola hemorrhagic fever, also known as Ebola virus disease is a viral hemorrhagic fever of humans and other primates caused by ebolaviruses.

Influenza, commonly known as "the flu", is an infectious disease caused by an influenza virus.

Newcastle disease is a contagious bird disease affecting many domestic and wild avian species; it is transmissible to humans.

Measles, also known as morbilli, is a highly contagious viral infection of the respiratory system, immune system, and skin caused by a paramyxovirus of the genus Morbillivirus.

Kaposi's sarcoma is a type of cancer that can form masses in the skin, lymph nodes, or other organs.

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Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.

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Rinderpest (also cattle plague or steppe murrain) was an infectious viral disease of cattle, domestic buffalo, and many other species of even-toed ungulates, including buffaloes, large antelope and deer, giraffes, wildebeests, and warthogs.

A female reproductive organ cancer that is located in the ovary.

Cholangiocarcinoma, also known as bile duct cancer or "sneaky Pete", is a form of cancer that is composed of mutated epithelial cells (or cells showing characteristics of epithelial differentiation) that originate in the bile ducts which drain bile from the liver into the small intestine.

Dyschromatosis Symmetrica Hereditaria is a rare autosomally inherited dermatosis. It is characterized by progressively pigmented and depigmented macules, often mixed in a reticulate pattern, concentrated on the dorsal extremities.?

A myeloid neoplasm that is located in the plasma cells in bone marrow.

Neurofibromatosis is a group of three conditions in which tumors grow in the nervous system.

The frontotemporal dementias (FTD) encompass six types of dementia involving the frontal or temporal lobes. They are: behavioral variant of FTD, semantic variant primary progressive aphasia, nonfluent agrammatic variant primary progressive aphasia, corticobasal syndrome, progressive supranuclear palsy, and FTD associated with motor neuron disease.

Progressive supranuclear palsy is a degenerative disease involving the gradual deterioration and death of specific volumes of the brain.

A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.

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A spinal cord injury is damage to the spinal cord that causes temporary or permanent changes in its function.

Human immunodeficiency virus infectious disease is a viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers.

Vesicular stomatitis Indiana virus is a virus in the family Rhabdoviridae.The main sign in animals is oral disease appearing as mucosal vesicles and ulcers in the mouth, but also on the udder and around the coronary band. Animals may show systemic signs such as anorexia, lethargy and pyrexia. Disease usually resolves within two weeks, and animals usually recover completely.

Anxiety disorders are a group of mental disorders characterized by significant feelings of anxiety and fear.[2] Anxiety is a worry about future events, and fear is a reaction to current events.[2] These feelings may cause physical symptoms, such as a fast heart rate and shakiness.

A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries.