English 简体中文
Home People
Zhang Zhang
Zhang Zhang

Professor

Email: zhangzhang (AT) big.ac.cn

Tel: +86 (10) 8409-7261

Chinese Name: 章张  [Google Scholar]

致同学们：在你决定是否选择我做导师前，务必三思。我是一位非著名学者，因此招生有一个基本原则：你别太好，免得我耽误你；也别太差，免得你耽误我。我理解你在选择导师时的盲目性，但你是否真有兴趣去做数据库、算法等基础研究工作。如果你之前没有努力学习、认真生活的实践，你来到我这里会感到很难过。千万不要送礼，实在想送，毕业后可参考新基石科研项目。研究生阶段，师生更多的是团队合作关系，自主内驱、积极主动、协同攻坚、有效沟通非常重要，否则研究生阶段难有收获。有些性格妨碍沟通：自甘平庸，过分轻狂......科研如翻山越岭，定力、耐力、体力都很重要，勇敢面对，坚持不懈，遇到挑战和失败依然乐观前行，没有人能随随便便成功，谁都不例外。最后，欢迎报考，有勇气才会有运气。放心，我可能不是你最好的选择，但肯定不是你最差的选择（全局最优很难，局部最优不易）。（─节选改编自中科院计算所贺思敏老师）

非官方译文：

  • Nothing in biology makes sense except in the light of evolution.  ─Theodosius Dobzhansky
    明进化之光，格生命之谛。─章张（注：出自“明德格物”）

  • I don't think we can get a Nobel prize by what we are doing, but the Nobel prize winners know what we are doing for.  ─Alan Bleasby
    功成不必在我，功成必定有我。─章张

PROFESSIONAL EXPERIENCE

  • Associate Director of National Genomics Data Center (NGDC), Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation (CNCB), China, 2020 - Present

  • Associate Director of BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2016 - 2020

  • Professor, University of Chinese Academy of Sciences (UCAS), China, 2015 - Present

  • Professor in the CAS 100-Talent Program, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2011 - Present

  • Research Scientist, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia, 2009 - 2011

  • Postdoctoral Associate, Yale University, United States of America, 2007 - 2009

EDUCATION

  • PhD in Computer Science, Institute of Computing Technology, Chinese Academy of Sciences, China, 2007

  • MS in Computer Science, Nanjing University of Science and Technology, China, 2004

  • BS in Computer Science, Ningxia University, China, 2002

HONORS & AWARDS

  • 2022年中国科学院特聘研究员（Distinguished Professor of Chinese Academy of Sciences, August 2022）

  • 2021年度“全球前2%顶尖科学家”（World's Top 2% Scientists 2021）

  • 2021年中国科学院大学-BHPB导师科研奖（UCAS-BHPB Excellent Supervisor Award, November 2021）

  • 2020年中国科学院大学“领雁金奖”引航奖（UCAS Lingyan Golden Award, September 2020）

  • 2019年国家“万人计划”青年拔尖人才（National Ten Thousand Talent Program for Young Top-notch Talent, February 2019）

  • 2018年“长江学者奖励计划”青年学者（Chang Jiang Youth Scholar, 2018）

  • 2018年中国科学院大学-BHPB导师科研奖（UCAS-BHPB Excellent Supervisor Award, September 2018）

  • 2017年中国科学院北京基因组研究所特聘研究员（Distinguished Professor of Beijing Institute of Genomics, September 2017）

  • 2017年中国科学院“百人计划”终期评估优秀奖（Excellence Award in the Final Evaluation of the CAS 100-Talent Program, August 2017）

AWARDS OF SUPERVISED STUDENTS

  • 2022年博士研究生国家奖学金 - 刘晓楠

  • 2022年度中国科学院院长奖 - 滕徐菲

  • 2021年中国科学院-必和必拓BHPB奖 - 滕徐菲

  • 2021年博士研究生国家奖学金 - 李昭

  • 2021年硕士研究生国家奖学金 - 朱彤彤

  • 2021年北京市普通高等学校优秀毕业生 - 刘琳

  • 2020年博士研究生国家奖学金 - 刘琳

  • 2020年硕士研究生国家奖学金 - 张源笙

  • 2020年第二届精准医学前沿研究生学术论坛论文荣誉奖 - 刘琳

  • 2020年第二届精准医学前沿研究生学术论坛最佳论文三等奖 - 滕徐菲

  • 2019年第四届国际生命与健康大数据论坛最佳报告奖 - 滕徐菲

  • 2019年北京市普通高等学校优秀毕业生 - 王佩

  • 2019年硕士研究生国家奖学金 - 王佩

  • 2019年北京市普通高等学校优秀毕业生 - 桑健

  • 2018年博士研究生国家奖学金 - 桑健

  • 2018年硕士研究生国家奖学金 - 曹佳宝

  • 2018年中国科学院-必和必拓BHPB奖 - 桑健

  • 2017年地奥奖学金 - 徐行健

RESEARCH INTERESTS

  • 生物大数据整合审编与数据库系统研发：面向我国人口健康和重要战略生物资源，建立海量多组学数据资源体系，研发多层次组学数据库、信息库与知识库系统，发展生物大数据公共资源生态系统理论。

    Big Data Integration and Curation: construction of multi-omics databases and knowledgebases by big data integration and curation and development of new theory for biological big data commons and ecosystem, with particular focuses on public health and national strategic important species.


  • 计算分子进化与自然选择压力检测：发展分子序列在核苷酸和密码子水平上的演化新模型和新理论，研发自然选择压力检测新方法与新技术。

    Computational Molecular Evolution: establishment of molecular evolutionary models and theories at the nucleotide and codon levels and development of new methods and tools for detecting national selection pressure.


  • 健康基因组数据智能深度挖掘：围绕人类脑胶质瘤等重大疾病，基于人工智能、机器学习、统计学习等多学科前沿交叉技术，研发面向精准医学的肿瘤多组学数据与健康数据的整合分析和深度挖掘的新方法与新技术。

    Computational Health Genomics: development of new methods and algorithms by associating omics data with health data and conducting integrative data analysis and deep mining via artificial intelligence and machine learning, with the aim to provide more effective ways for precision health and medical treatment for brain tumors, like glioma.

TEACHING

  • Introduction to Omics (for graduates; in English)

  • Bioinformatics, Genomics, Big Data (for graduates; in Chinese)

  • Genomics (for undergraduates; in Chinese)

FEATURED PROJECTS & RESOURCES

ACADEMIC ACTIVITIES

PUBLICATIONS

  1. Ma L, Zou D, Liu L, Shireen H, Abbasi AA, Bateman A, Xiao J, Zhao W, Bao Y, Zhang Z: Database Commons: A Catalog of Worldwide Biological Databases. Genomics Proteomics Bioinformatics 2023, epub online. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36572336

  2. Jiang S, Qian Q, Zhu T, Zong W, Shang Y, Jin T, Zhang Y, Chen M, Wu Z, Chu Y, Zhang R, Luo S, Jing W, Zou D, Bao Y, Xiao J, Zhang Z: Cell Taxonomy: a curated repository of cell types with multifaceted characterization. Nucleic Acids Res 2023, 51(D1):D853-D860. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36161321

  3. Zhang M, Zong W, Zou D, Wang G, Zhao W, Yang F, Wu S, Zhang X, Guo X, Ma Y, Xiong Z, Zhang Z, Bao Y, Li R: MethBank 4.0: an updated database of DNA methylation across a variety of species. Nucleic Acids Res 2023, 51(D1):D208-D216. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36318250

  4. Pan S, Kang H, Liu X, Lin S, Yuan N, Zhang Z, Bao Y, Jia P: Brain Catalog: a comprehensive resource for the genetic landscape of brain-related traits. Nucleic Acids Res 2023, 51(D1):D835-D844. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36243988

  5. Liu X, Tian D, Li C, Tang B, Wang Z, Zhang R, Pan Y, Wang Y, Zou D, Zhang Z, Song S: GWAS Atlas: an updated knowledgebase integrating more curated associations in plants and animals. Nucleic Acids Res 2023, 51(D1):D969-D976. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36263826

  6. Li Z, Liu L, Feng C, Qin Y, Xiao J, Zhang Z, Ma L: LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations. Nucleic Acids Res 2023, 51(D1):D186-D191. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36330950

  7. Hua Z, Jiang C, Song S, Tian D, Chen Z, Jin Y, Zhao Y, Zhou J, Zhang Z, Huang L, Yuan Y: Accurate identification of taxon-specific molecular markers in plants based on DNA signature sequence. Mol Ecol Resour 2023, 23(1):106-117. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-35951477

  8. Duan G, Wu G, Chen X, Tian D, Li Z, Sun Y, Du Z, Hao L, Song S, Gao Y, Xiao J, Zhang Z, Bao Y, Tang B, Zhao W: HGD: an integrated homologous gene database across multiple species. Nucleic Acids Res 2023, 51(D1):D994-D1002. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36318261

  9. CNCB-NGDC Members & Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023. Nucleic Acids Res 2023, 51(D1):D18-D28. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36420893

  10. 李茹姣, 张欣, 宋述慧, 王彦青, 邹东, 肖景发, 赵文明, 章张, 鲍一明: 基因组科学数据的安全管理与应用. 大数据 2022, 8(1):37-45.

  11. Zhang ZW, Teng X, Zhao F, Ma C, Zhang J, Xiao LF, Wang Y, Chang M, Tian Y, Li C, Zhang Z, Song S, Tong WM, Liu P, Niu Y: METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Rep 2022, 41(4):111530. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36288719

  12. Zhang Z: KaKs_Calculator 3.0: Calculating Selective Pressure on Coding and Non-coding Sequences. Genomics Proteomics Bioinformatics 2022, 20(3):536-540. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34990803

  13. Zhang Y, Zou D, Zhu T, Xu T, Chen M, Niu G, Zong W, Pan R, Jing W, Sang J, Liu C, Xiong Y, Sun Y, Zhai S, Chen H, Zhao W, Xiao J, Bao Y, Hao L, Zhang Z: Gene Expression Nebulas (GEN): a comprehensive data portal integrating transcriptomic profiles across multiple species at both bulk and single-cell levels. Nucleic Acids Res 2022, 50(D1):D1016-D1024. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34591957

  14. Xiong Z, Yang F, Li M, Ma Y, Zhao W, Wang G, Li Z, Zheng X, Zou D, Zong W, Kang H, Jia Y, Li R, Zhang Z, Bao Y: EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study. Nucleic Acids Res 2022, 50(D1):D1004-D1009. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718752

  15. Liu L, Zhang Y, Niu G, Li Q, Li Z, Zhu T, Feng C, Liu X, Zhang Y, Xu T, Chen R, Teng X, Zhang R, Zou D, Ma L, Zhang Z: BrainBase: a curated knowledgebase for brain diseases. Nucleic Acids Res 2022, 50(D1):D1131-D1138. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718720

  16. Liu L, Li Z, Liu C, Zou D, Li Q, Feng C, Jing W, Luo S, Zhang Z, Ma L: LncRNAWiki 2.0: a knowledgebase of human long non-coding RNAs with enhanced curation model and database system. Nucleic Acids Res 2022, 50(D1):D190-D195. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34751395

  17. Jiang S, Du Q, Feng C, Ma L, Zhang Z: CompoDynamics: a comprehensive database for characterizing sequence composition dynamics. Nucleic Acids Res 2022, 50(D1):D962-D969. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718745

  18. Jia L, Li Y, Huang F, Jiang Y, Li H, Wang Z, Chen T, Li J, Zhang Z, Yao W: LIRBase: a comprehensive database of long inverted repeats in eukaryotic genomes. Nucleic Acids Res 2022, 50(D1):D174-D182. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34643715

  19. Hua Z, Tian D, Jiang C, Song S, Chen Z, Zhao Y, Jin Y, Huang L, Zhang Z, Yuan Y: Towards comprehensive integration and curation of chloroplast genomes. Plant Biotechnol J 2022, 20(12):2239-2241. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36069606

  20. CNCB-NGDC Members & Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022. Nucleic Acids Res 2022, 50(D1):D27-D38. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718731

  21. Cao J, Zhang Y, Tan S, Yang Q, Wang H-L, Xia X, Luo J, Guo H, Zhang Z, Li Z: LSD 4.0: an improved database for comparative studies of leaf senescence. Molecular Horticulture 2022, 2(1):24.

  22. Zhang SS, Chen X, Chen TT, Zhu JW, Tang BX, Wang AK, Dong LL, Zhang ZW, Sun YL, Yu CX, Zhai S, Sun YB, Chen HX, Du ZL, Xiao JF, Zhang Z, Bao YM, Wang YQ, Zhao WM: GSA-Human: Genome Sequence Archive for Human. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2021, 43(10):988-993. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34702711

  23. Sun C, Huang J, Wang Y, Zhao X, Su L, Thomas GWC, Zhao M, Zhang X, Jungreis I, Kellis M, Vicario S, Sharakhov IV, Bondarenko SM, Hasselmann M, Kim CN, Paten B, Penso-Dolfin L, Wang L, Chang Y, Gao Q, Ma L, Ma L, Zhang Z, Zhang H, Zhang H, Ruzzante L, Robertson HM, Zhu Y, Liu Y, Yang H, Ding L, Wang Q, Ma D, Xu W, Liang C, Itgen MW, Mee L, Cao G, Zhang Z, Sadd BM, Hahn MW, Schaack S, Barribeau SM, Williams PH, Waterhouse RM, Mueller RL: Genus-Wide Characterization of Bumblebee Genomes Provides Insights into Their Evolution and Variation in Ecological and Behavioral Traits. Mol Biol Evol 2021, 38(2):486-501. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32946576

  24. RNAcentral Consortium: RNAcentral 2021: secondary structure integration, improved sequence search and new member databases. Nucleic Acids Res 2021, 49(D1):D212-D220. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33106848

  25. Liu X, Wang P, Teng X, Zhang Z, Song S: Comprehensive Analysis of Expression Regulation for RNA m6A Regulators With Clinical Significance in Human Cancers. Front Oncol 2021, 11:624395. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33718187

  26. Li Z, Liu L, Jiang S, Li Q, Feng C, Du Q, Zou D, Xiao J, Zhang Z, Ma L: LncExpDB: an expression database of human long non-coding RNAs. Nucleic Acids Res 2021, 49(D1):D962-D968. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33045751

  27. Li C, Tian D, Tang B, Liu X, Teng X, Zhao W, Zhang Z, Song S: Genome Variation Map: a worldwide collection of genome variations across multiple species. Nucleic Acids Res 2021, 49(D1):D1186-D1191. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33170268

  28. CNCB-NGDC Members & Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. Nucleic Acids Res 2021, 49(D1):D18-D28. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33175170

  29. Chen T, Chen X, Zhang S, Zhu J, Tang B, Wang A, Dong L, Zhang Z, Yu C, Sun Y, Chi L, Chen H, Zhai S, Sun Y, Lan L, Zhang X, Xiao J, Bao Y, Wang Y, Zhang Z, Zhao W: The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types. Genomics Proteomics Bioinformatics 2021, 19(4):578-583. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34400360

  30. Chen M, Ma Y, Wu S, Zheng X, Kang H, Sang J, Xu X, Hao L, Li Z, Gong Z, Xiao J, Zhang Z, Zhao W, Bao Y: Genome Warehouse: A Public Repository Housing Genome-scale Data. Genomics Proteomics Bioinformatics 2021, 19(4):584-589. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34175476

  31. Zhao WM, Song SH, Chen ML, Zou D, Ma LN, Ma YK, Li RJ, Hao LL, Li CP, Tian DM, Tang BX, Wang YQ, Zhu JW, Chen HX, Zhang Z, Xue YB, Bao YM: The 2019 novel coronavirus resource. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2020, 42(2):212-221. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32102777

  32. Zhang Z, Song S, Yu J, Zhao W, Xiao J, Bao Y: The Elements of Data Sharing. Genomics Proteomics Bioinformatics 2020, 18(1):1-4. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32360769

  33. Yan J, Zou D, Li C, Zhang Z, Song S, Wang X: SR4R: An Integrative SNP Resource for Genomic Breeding and Population Research in Rice. Genomics Proteomics Bioinformatics 2020, 18(2):173-185. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32619768

  34. Xiong Z, Li M, Yang F, Ma Y, Sang J, Li R, Li Z, Zhang Z, Bao Y: EWAS Data Hub: a resource of DNA methylation array data and metadata. Nucleic Acids Res 2020, 48(D1):D890-D895. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31584095

  35. Tian D, Wang P, Tang B, Teng X, Li C, Liu X, Zou D, Song S, Zhang Z: GWAS Atlas: a curated resource of genome-wide variant-trait associations in plants and animals. Nucleic Acids Res 2020, 48(D1):D927-D932. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31566222

  36. Teng X, Li Q, Li Z, Zhang Y, Niu G, Xiao J, Yu J, Zhang Z, Song S: Compositional Variability and Mutation Spectra of Monophyletic SARS-CoV-2 Clades. Genomics Proteomics Bioinformatics 2020, 18(6):648-663. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33581339

  37. Song S, Ma L, Zou D, Tian D, Li C, Zhu J, Chen M, Wang A, Ma Y, Li M, Teng X, Cui Y, Duan G, Zhang M, Jin T, Shi C, Du Z, Zhang Y, Liu C, Li R, Zeng J, Hao L, Jiang S, Chen H, Han D, Xiao J, Zhang Z, Zhao W, Xue Y, Bao Y: The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR. Genomics Proteomics Bioinformatics 2020, 18(6):749-759. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33704069

  38. Sang J, Zou D, Wang Z, Wang F, Zhang Y, Xia L, Li Z, Ma L, Li M, Xu B, Liu X, Wu S, Liu L, Niu G, Li M, Luo Y, Hu S, Hao L, Zhang Z: IC4R-2.0: Rice Genome Reannotation Using Massive RNA-seq Data. Genomics Proteomics Bioinformatics 2020, 18(2):161-172. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32683045

  39. National Genomics Data Center Members & Partners: Database Resources of the National Genomics Data Center in 2020. Nucleic Acids Res 2020, 48(D1):D24-D33. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31702008

  40. Miao W, Song L, Ba S, Zhang L, Guan G, Zhang Z, Ning K: Protist 10,000 Genomes Project. Innovation (Camb) 2020, 1(3):100058. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34557722

  41. Liu L, Wang G, Wang L, Yu C, Li M, Song S, Hao L, Ma L, Zhang Z: Computational identification and characterization of glioma candidate biomarkers through multi-omics integrative profiling. Biol Direct 2020, 15(1):10. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32539851

  42. Li Z, Zhang Y, Zou D, Zhao Y, Wang HL, Zhang Y, Xia X, Luo J, Guo H, Zhang Z: LSD 3.0: a comprehensive resource for the leaf senescence research community. Nucleic Acids Res 2020, 48(D1):D1069-D1075. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31599330

  43. Li Q, Li Z, Feng C, Jiang S, Zhang Z, Ma L: Multi-omics annotation of human long non-coding RNAs. Biochem Soc Trans 2020, 48(4):1545-1556. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32756901

  44. Gong Z, Zhu JW, Li CP, Jiang S, Ma LN, Tang BX, Zou D, Chen ML, Sun YB, Song SH, Zhang Z, Xiao JF, Xue YB, Bao YM, Du ZL, Zhao WM: An online coronavirus analysis platform from the National Genomics Data Center. Zool Res 2020, 41(6):705-708. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33045776

  45. Zhao Y, Wang J, Liang F, Liu Y, Wang Q, Zhang H, Jiang M, Zhang Z, Zhao W, Bao Y, Zhang Z, Wu J, Asmann YW, Li R, Xiao J: NucMap: a database of genome-wide nucleosome positioning map across species. Nucleic Acids Res 2019, 47(D1):D163-D169. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30335176

  46. Zhang Z, Yu J, Eisenhaber F, Gao X, Gojobori T: In Memory of Vladimir B. Bajic (1952–2019). Genomics, Proteomics & Bioinformatics 2019, 17(5):473-474. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-WOS:000518438500001

  47. Yin H, Li M, Xia L, He C, Zhang Z: Computational determination of gene age and characterization of evolutionary dynamics in human. Brief Bioinform 2019, 20(6):2141-2149. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30184145

  48. Wang G, Yin H, Li B, Yu C, Wang F, Xu X, Cao J, Bao Y, Wang L, Abbasi AA, Bajic VB, Ma L, Zhang Z: Characterization and identification of long non-coding RNAs based on feature relationship. Bioinformatics 2019, 35(17):2949-2956. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30649200

  49. The RNAcentral Consortium: RNAcentral: a hub of information for non-coding RNA sequences. Nucleic Acids Res 2019, 47(D1):D221-D229. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30395267

  50. Tang B, Zhou Q, Dong L, Li W, Zhang X, Lan L, Zhai S, Xiao J, Zhang Z, Bao Y, Zhang YP, Wang GD, Zhao W: iDog: an integrated resource for domestic dogs and wild canids. Nucleic Acids Res 2019, 47(D1):D793-D800. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30371881

  51. Song S, Zhang Z: Database Resources in BIG Data Center: Submission, Archiving, and Integration of Big Data in Plant Science. Molecular plant 2019, 12(3):279-281. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30716410

  52. Pervaiz N, Shakeel N, Qasim A, Zehra R, Anwar S, Rana N, Xue Y, Zhang Z, Bao Y, Abbasi AA: Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals. BMC Evol Biol 2019, 19(1):128. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31221090

  53. Niu G, Zou D, Li M, Zhang Y, Sang J, Xia L, Li M, Liu L, Cao J, Zhang Y, Wang P, Hu S, Hao L, Zhang Z: Editome Disease Knowledgebase (EDK): a curated knowledgebase of editome-disease associations in human. Nucleic Acids Res 2019, 47(D1):D78-D83. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30357418

  54. Ma L, Cao J, Liu L, Li Z, Shireen H, Pervaiz N, Batool F, Raza RZ, Zou D, Bao Y, Abbasi AA, Zhang Z: Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook. Curr Protoc Bioinformatics 2019, 67(1):e82. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31524988

  55. Ma L, Cao J, Liu L, Du Q, Li Z, Zou D, Bajic VB, Zhang Z: LncBook: a curated knowledgebase of human long non-coding RNAs. Nucleic Acids Res 2019, 47(D1):D128-D134. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30329098

  56. Li M, Zou D, Li Z, Gao R, Sang J, Zhang Y, Li R, Xia L, Zhang T, Niu G, Bao Y, Zhang Z: EWAS Atlas: a curated knowledgebase of epigenome-wide association studies. Nucleic Acids Res 2019, 47(D1):D983-D988. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30364969

  57. Li M, Xia L, Zhang Y, Niu G, Li M, Wang P, Zhang Y, Sang J, Zou D, Hu S, Hao L, Zhang Z: Plant editosome database: a curated database of RNA editosome in plants. Nucleic Acids Res 2019, 47(D1):D170-D174. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30364952

  58. BIG Data Center Members: Database Resources of the BIG Data Center in 2019. Nucleic Acids Res 2019, 47(D1):D8-D14. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30365034

  59. Zhang Z, Xue Y, Zhao F: Bioinformatics Commons: The Cornerstone of Life and Health Sciences. Genomics Proteomics Bioinformatics 2018, 16(4):223-225. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30268933

  60. Zhang YS, Xia L, Sang J, Li M, Liu L, Li MW, Niu GY, Cao JB, Teng XF, Zhou Q, Zhang Z: [The BIG Data Center's database resources]. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2018, 40(11):1039-1043. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30465537

  61. Song S, Tian D, Zhang Z, Hu S, Yu J: Rice Genomics: over the Past Two Decades and into the Future. Genomics Proteomics Bioinformatics 2018, 16(6):397-404. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30771506

  62. Song S, Tian D, Li C, Tang B, Dong L, Xiao J, Bao Y, Zhao W, He H, Zhang Z: Genome Variation Map: a data repository of genome variations in BIG Data Center. Nucleic Acids Res 2018, 46(D1):D944-D949. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29069473

  63. Sang J, Wang Z, Li M, Cao J, Niu G, Xia L, Zou D, Wang F, Xu X, Han X, Fan J, Yang Y, Zuo W, Zhang Y, Zhao W, Bao Y, Xiao J, Hu S, Hao L, Zhang Z: ICG: a wiki-driven knowledgebase of internal control genes for RT-qPCR normalization. Nucleic Acids Res 2018, 46(D1):D121-D126. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29036693

  64. Li R, Liang F, Li M, Zou D, Sun S, Zhao Y, Zhao W, Bao Y, Xiao J, Zhang Z: MethBank 3.0: a database of DNA methylomes across a variety of species. Nucleic Acids Res 2018, 46(D1):D288-D295. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29161430

  65. International Society for B: Biocuration: Distilling data into knowledge. PLoS Biol 2018, 16(4):e2002846. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29659566

  66. BIG Data Center Members: Database Resources of the BIG Data Center in 2018. Nucleic Acids Res 2018, 46(D1):D14-D20. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29036542

  67. Zhao ZM, Campbell MC, Li N, Lee DSW, Zhang Z, Townsend JP: Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence. Mol Biol Evol 2017, 34(11):3006-3022. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28962009

  68. Xu X, Ji Z, Zhang Z: CloudPhylo: a fast and scalable tool for phylogeny reconstruction. Bioinformatics 2017, 33(3):438-440. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28172557

  69. Xia L, Zou D, Sang J, Xu X, Yin H, Li M, Wu S, Hu S, Hao L, Zhang Z: Rice Expression Database (RED): An integrated RNA-Seq-derived gene expression database for rice. J Genet Genomics 2017, 44(5):235-241. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28529082

  70. Wang Y, Song F, Zhu J, Zhang S, Yang Y, Chen T, Tang B, Dong L, Ding N, Zhang Q, Bai Z, Dong X, Chen H, Sun M, Zhai S, Sun Y, Yu L, Lan L, Xiao J, Fang X, Lei H, Zhang Z, Zhao W: GSA: Genome Sequence Archive<sup/>. Genomics Proteomics Bioinformatics 2017, 15(1):14-18. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28387199

  71. The RNAcentral Consortium: RNAcentral: a comprehensive database of non-coding RNA sequences. Nucleic Acids Res 2017, 45(D1):D128-D134. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27794554

  72. Salhi A, Essack M, Alam T, Bajic VP, Ma L, Radovanovic A, Marchand B, Schmeier S, Zhang Z, Bajic VB: DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining. RNA Biol 2017, 14(7):963-971. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28387604

  73. BIG Data Center Members: The BIG Data Center: from deposition to integration to translation. Nucleic Acids Res 2017, 45(D1):D18-D24. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27899658

  74. Zhao W, Zhang S, Tang B, Chen T, Hao L, Sang J, Li R, Xiao J, Zhang Z: Constructing the international database management system for omics big data. Big Data Research 2016, 2(6):43-52.

  75. Yin H, Wang G, Ma L, Yi SV, Zhang Z: What Signatures Dominantly Associate with Gene Age? Genome Biol Evol 2016, 8(10):3083-3089. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27609935

  76. Yin H, Ma L, Wang G, Li M, Zhang Z: Old genes experience stronger translational selection than young genes. Gene 2016, 590(1):29-34. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27259662

  77. Xue Y, Lameijer EW, Ye K, Zhang K, Chang S, Wang X, Wu J, Gao G, Zhao F, Li J, Han C, Xu S, Xiao J, Yang X, Ying X, Zhang X, Chen WH, Liu Y, Zhang Z, Huang K, Yu J: Precision Medicine: What Challenges Are We Facing? Genomics Proteomics Bioinformatics 2016, 14(5):253-261. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27744061

  78. Wang G, Sun S, Zhang Z: Randomness in Sequence Evolution Increases over Time. PLoS One 2016, 11(5):e0155935. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27224236

  79. Tian X, Zhang Z, Yang T, Chen M, Li J, Chen F, Yang J, Li W, Zhang B, Zhang Z, Wu J, Zhang C, Long L, Xiao J: Comparative Genomics Analysis of Streptomyces Species Reveals Their Adaptation to the Marine Environment and Their Diversity at the Genomic Level. Front Microbiol 2016, 7:998. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27446038

  80. Sun S, Xiao J, Zhang H, Zhang Z: Pangenome Evidence for Higher Codon Usage Bias and Stronger Translational Selection in Core Genes of Escherichia coli. Front Microbiol 2016, 7:1180. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27536275

  81. IC4R Project Consortium: Information Commons for Rice (IC4R). Nucleic Acids Res 2016, 44(D1):D1172-1180. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-26519466

  82. Zou D, Sun S, Li R, Liu J, Zhang J, Zhang Z: MethBank: a database integrating next-generation sequencing single-base-resolution DNA methylation programming data. Nucleic Acids Res 2015, 43(Database issue):D54-58. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25294826

  83. Zou D, Ma L, Yu J, Zhang Z: Biological databases for human research. Genomics Proteomics Bioinformatics 2015, 13(1):55-63. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25712261

  84. Zhang Y, Chen L, Zhang Z: The Curation and Analysis of Rice Stress-Resistance Genes Based on RiceWiki. Hans Journal of Computational Biology 2015, 5(3):29-40.

  85. Ma L, Li A, Zou D, Xu X, Xia L, Yu J, Bajic VB, Zhang Z: LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs. Nucleic Acids Res 2015, 43(Database issue):D187-192. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25399417

  86. Bai B, Zhao WM, Tang BX, Wang YQ, Wang L, Zhang Z, Yang HC, Liu YH, Zhu JW, Irwin DM, Wang GD, Zhang YP: DoGSD: the dog and wolf genome SNP database. Nucleic Acids Res 2015, 43(Database issue):D777-783. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25404132

  87. Zhao Y, Jia X, Yang J, Ling Y, Zhang Z, Yu J, Wu J, Xiao J: PanGP: a tool for quickly analyzing bacterial pan-genome profile. Bioinformatics 2014, 30(9):1297-1299. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-24420766

  88. Zhang Z, Zhu W, Luo J: Bringing biocuration to China. Genomics Proteomics Bioinformatics 2014, 12(4):153-155. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25042682

  89. Zhang Z, Sang J, Ma L, Wu G, Wu H, Huang D, Zou D, Liu S, Li A, Hao L, Tian M, Xu C, Wang X, Wu J, Xiao J, Dai L, Chen LL, Hu S, Yu J: RiceWiki: a wiki-based database for community curation of rice genes. Nucleic Acids Res 2014, 42(Database issue):D1222-1228. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-24136999

  90. Xu P, Zhang X, Wang X, Li J, Liu G, Kuang Y, Xu J, Zheng X, Ren L, Wang G, Zhang Y, Huo L, Zhao Z, Cao D, Lu C, Li C, Zhou Y, Liu Z, Fan Z, Shan G, Li X, Wu S, Song L, Hou G, Jiang Y, Jeney Z, Yu D, Wang L, Shao C, Song L, Sun J, Ji P, Wang J, Li Q, Xu L, Sun F, Feng J, Wang C, Wang S, Wang B, Li Y, Zhu Y, Xue W, Zhao L, Wang J, Gu Y, Lv W, Wu K, Xiao J, Wu J, Zhang Z, Yu J, Sun X: Genome sequence and genetic diversity of the common carp, Cyprinus carpio. Nat Genet 2014, 46(11):1212-1219. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25240282

  91. Wu J, Xiao J, Zhang Z, Wang X, Hu S, Yu J: Ribogenomics: the science and knowledge of RNA. Genomics Proteomics Bioinformatics 2014, 12(2):57-63. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-24769101

  92. Wu H, Fang Y, Yu J, Zhang Z: The quest for a unified view of bacterial land colonization. The ISME journal 2014, 8(7):1358-1369. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-24451209

  93. Wu G, Zhu J, Yu J, Zhou L, Huang JZ, Zhang Z: Evaluation of five methods for genome-wide circadian gene identification. Journal of biological rhythms 2014, 29(4):231-242. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25238853

  94. Ma L, Cui P, Zhu J, Zhang Z, Zhang Z: Translational selection in human: more pronounced in housekeeping genes. Biol Direct 2014, 9:17. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25011537

  95. Kang Y, Gu C, Yuan L, Wang Y, Zhu Y, Li X, Luo Q, Xiao J, Jiang D, Qian M, Ahmed Khan A, Chen F, Zhang Z, Yu J: Flexibility and symmetry of prokaryotic genome rearrangement reveal lineage-associated core-gene-defined genome organizational frameworks. mBio 2014, 5(6):e01867. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25425232

  96. Zhang Z, Yu J: Does the genetic code have a eukaryotic origin? Genomics Proteomics Bioinformatics 2013, 11(1):41-55. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23402863

  97. Wu J, Xiao J, Wang L, Zhong J, Yin H, Wu S, Zhang Z, Yu J: Systematic analysis of intron size and abundance parameters in diverse lineages. Sci China Life Sci 2013, 56(10):968-974. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-24022126

  98. Tong X, Yang Y, Wang W, Bai Z, Ma L, Zheng X, Sun H, Zhang Z, Zhao M, Yu J, Ge RL: Expression profiling of abundant genes in pulmonary and cardiac muscle tissues of Tibetan Antelope (Pantholops hodgsonii). Gene 2013, 523(2):187-191. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23612247

  99. Ma L, Bajic VB, Zhang Z: On the classification of long non-coding RNAs. RNA Biol 2013, 10(6):925-933. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23696037

  100. Dai L, Xu C, Tian M, Sang J, Zou D, Li A, Liu G, Chen F, Wu J, Xiao J, Wang X, Yu J, Zhang Z: Community intelligence in knowledge curation: an application to managing scientific nomenclature. PLoS One 2013, 8(2):e56961. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23451119

  101. Dai L, Tian M, Wu J, Xiao J, Wang X, Townsend JP, Zhang Z: AuthorReward: increasing community curation in biological knowledge wikis through automated authorship quantification. Bioinformatics 2013, 29(14):1837-1839. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23732274

  102. Chen M, Xiao J, Zhang Z, Liu J, Wu J, Yu J: Identification of human HK genes and gene expression regulation study in cancer from transcriptomics data analysis. PLoS One 2013, 8(1):e54082. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23382867

  103. Zhang Z, Yu J: The pendulum model for genome compositional dynamics: from the four nucleotides to the twenty amino acids. Genomics Proteomics Bioinformatics 2012, 10(4):175-180. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23084772

  104. Zhang Z, Xiao J, Wu J, Zhang H, Liu G, Wang X, Dai L: ParaAT: a parallel tool for constructing multiple protein-coding DNA alignments. Biochem Biophys Res Commun 2012, 419(4):779-781. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-22390928

  105. Zhang Z, Li J, Cui P, Ding F, Li A, Townsend JP, Yu J: Codon Deviation Coefficient: a novel measure for estimating codon usage bias and its statistical significance. BMC Bioinformatics 2012, 13(1):43. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-22435713

  106. Wu H, Zhang Z, Hu S, Yu J: On the molecular mechanism of GC content variation among eubacterial genomes. Biol Direct 2012, 7(1):2. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-22230424

  107. Wu H, Qu H, Wan N, Zhang Z, Hu S, Yu J: Strand-biased gene distribution in bacteria is related to both horizontal gene transfer and strand-biased nucleotide composition. Genomics Proteomics Bioinformatics 2012, 10(4):186-196. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23084774

  108. Dai L, Gao X, Guo Y, Xiao J, Zhang Z: Bioinformatics clouds for big data manipulation. Biol Direct 2012, 7:43; discussion 43. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23190475

  109. Cui P, Liu W, Zhao Y, Lin Q, Zhang D, Ding F, Xin C, Zhang Z, Song S, Sun F, Yu J, Hu S: Comparative analyses of H3K4 and H3K27 trimethylations between the mouse cerebrum and testis. Genomics Proteomics Bioinformatics 2012, 10(2):82-93. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-22768982

  110. Cui P, Ding F, Lin Q, Zhang L, Li A, Zhang Z, Hu S, Yu J: Distinct contributions of replication and transcription to mutation rate variation of human genomes. Genomics Proteomics Bioinformatics 2012, 10(1):4-10. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-22449396

  111. Zhang Z, Yu J: On the organizational dynamics of the genetic code. Genomics Proteomics Bioinformatics 2011, 9(1-2):21-29. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-21641559

  112. Zhang Z, Bajic VB, Yu J, Cheung K-H, Townsend JP: Data Integration in Bioinformatics: Current Efforts and Challenges. In: Bioinformatics - Trends and Methodologies. Edited by Mahdavi MA, vol. 1. Rijeka, Croatia: InTech; 2011: 41-56.

  113. Zhang Z, Yu J: Modeling compositional dynamics based on GC and purine contents of protein-coding sequences. Biol Direct 2010, 5:63. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-21059261

  114. Zhang Z, Townsend JP: The filamentous fungal gene expression database (FFGED). Fungal Genet Biol 2010, 47(3):199-204. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-20025988

  115. Zhang Z, Lopez-Giraldez F, Townsend JP: LOX: inferring Level Of eXpression from diverse methods of census sequencing. Bioinformatics 2010, 26(15):1918-1919. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-20538728

  116. Wang D, Zhang Y, Zhang Z, Zhu J, Yu J: KaKs_Calculator 2.0: a toolkit incorporating gamma-series methods and sliding window strategies. Genomics Proteomics Bioinformatics 2010, 8(1):77-80. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-20451164

  117. Qu H, Wu H, Zhang T, Zhang Z, Hu S, Yu J: Nucleotide compositional asymmetry between the leading and lagging strands of eubacterial genomes. Res Microbiol 2010, 161(10):838-846. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-20868744

  118. Zhang Z, Townsend JP: Maximum-likelihood model averaging to profile clustering of site types across discrete linear sequences. PLoS Comput Biol 2009, 5(6):e1000421. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-19557160

  119. Zhang Z, Cheung KH, Townsend JP: Bringing Web 2.0 to bioinformatics. Brief Bioinform 2009, 10(1):1-10. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-18842678

  120. Li J, Zhang Z, Vang S, Yu J, Wong GK, Wang J: Correlation between Ka/Ks and Ks is related to substitution model and evolutionary lineage. J Mol Evol 2009, 68(4):414-423. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-19308632

  121. Zheng H, Shi J, Fang X, Li Y, Vang S, Fan W, Wang J, Zhang Z, Wang W, Kristiansen K, Wang J: FGF: a web tool for Fishing Gene Family in a whole genome database. Nucleic Acids Res 2007, 35(Web Server issue):W121-125. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-17584790

  122. Zhao X, Zhang Z, Yan J, Yu J: GC content variability of eubacteria is governed by the pol III alpha subunit. Biochem Biophys Res Commun 2007, 356(1):20-25. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-17336933

  123. Hu J, Zhao X, Zhang Z, Yu J: Compositional dynamics of guanine and cytosine content in prokaryotic genomes. Res Microbiol 2007, 158(4):363-370. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-17449227

  124. Zhang Z, Yu J: Evaluation of six methods for estimating synonymous and nonsynonymous substitution rates. Genomics Proteomics Bioinformatics 2006, 4(3):173-181. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-17127215

  125. Zhang Z, Li J, Zhao XQ, Wang J, Wong GK, Yu J: KaKs_Calculator: calculating Ka and Ks through model selection and model averaging. Genomics Proteomics Bioinformatics 2006, 4(4):259-263. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-17531802

  126. Zhang Z, Li J, Yu J: Computing Ka and Ks with a consideration of unequal transitional substitutions. BMC Evol Biol 2006, 6:44. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-16740169

  127. Li H, Coghlan A, Ruan J, Coin LJ, Heriche JK, Osmotherly L, Li R, Liu T, Zhang Z, Bolund L, Wong GK, Zheng W, Dehal P, Wang J, Durbin R: TreeFam: a curated database of phylogenetic trees of animal gene families. Nucleic Acids Res 2006, 34(Database issue):D572-580. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-16381935

SELECTED INVITED TALKS

  1. Towards a Universe of Human Long Non-coding RNAs. The 8th National Conference on Computational Biology and Bioinformatics (第八届全国计算生物学与生物信息学学术会议), Guangzhou, July 22-25, 2022.

  2. Biological Big Data Deposition, Public Sharing and Database Resources. The 10th National Conference on Bioinformatics and System Biology of China, Chengdu, October 25-29, 2021.

  3. Database Resources of the National Genomics Data Center. The 9th National Conference on Bioinformatics and System Biology of China, Shanghai, September 26-29, 2020.

  4. Computational genomics of brain tumors: glioma biomarker identification and characterization through multi-omics integrative molecular profiling. KAUST Research Conference Digital Health 2020, Thuwal, Saudi Arabia, January 20-22, 2020.

  5. Building a big data ecosystem for bioinformatics. The 4th Annual European Bioinformatics Core Community Workshop, Basel, Switzerland, 26 July 2019.

  6. 生命组学大数据管理与资源体系建设, 中国科学院青年创新促进会第一届青年生命科学论坛, 乌鲁木齐, 2019年7月12-16日.

  7. 生命组学数据资源体系建设, 第六届全国计算生物学与生物信息学学术会议, 成都, 2019年3月30-31日.

  8. Database Resources of the BIG Data Center in 2018. International Conference on Precision Medicine, Bangkok, Thailand, 19-20 July 2018.

  9. 基因大数据汇交共享与多组学数据资源体系建设, 北京生物信息学系列论坛, 北京大学, 2018年1月19日

  10. The BIG Data Center: from deposition to integration to translation. The Sino-ASEAN Conference on Precision Medicine, Burapha University, Thailand, 17-18 June 2017.

  11. The BIG Data Center’s database resources: towards precision medicine . The 10th International Biocuration Conference, Stanford University, United States, 26-29 March 2017.

  12. The BIG Data Center: from deposition to integration to translation. The 4th Youth Forum for Computer & Life Sciences Interdisciplinary Research (第四届数学、计算机与生命科学交叉研究青年学者论坛), Beijing, China, May 21-22, 2016.

  13. The BIG Data Center for Life and Health Sciences. The Phoenix City Forum for Genome Informatics (基因组信息学凤凰城论坛), Tangshan, China, May 13-15, 2016.

  14. The BIG Data Center: from deposition to integration to translation. The 9th International Biocuration Conference, Geneva, Switzerland, April 10-14, 2016.

  15. Big Data integration: scalability and sustainability. KAUST Research Conference on Computational and Experimental Interfaces of Big Data and Biotechnology, Thuwal, Saudi Arabia, Jan. 25-27, 2016.

  16. Toward Sustainability and Scalability for Big Data Integration. 2015 Functional Genomics Summit II, Beijing, China, Nov. 11-12, 2015.

  17. Community integration of big data. The 2015 International Conference of Genomics, Xi'an, China, Oct. 22-25, 2015.

  18. Bringing biocuration to China. The 1st International Coastal Biology Congress, Yantai, China, Sept. 26-30, 2014.

  19. Big data integration, curation, and analysis. The 3rd Young Bioinformatics PI Workshop, Guangzhou, China, Sept. 19-21, 2014.

  20. Biocuration in the era of big data. The Workshop on Statistical and Computational Theory and Methodology for Big Data Analysis, Banff, Canada, Feb. 9-14, 2014.

  21. Community curation in biological knowledge wikis. The 6th International Biocuration Conference, Churchill College, Cambridge, United Kingdom, April 7-10, 2013.

  22. Rewarding community-curated contributions in biological knowledge wikis. The High-throughput Sequencing Data Analysis and Approaches Workshop, Beijing, China, Dec. 5-7, 2012.

  23. Next-Generation Bioinformatics: harnessing collective resources for large-scale data manipulation, in workshop “Challenges and future of Bioinformatics: sharing insights from the Dutch and Chinese perspective”, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China, March 19, 2012.