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Zhang Zhang
Zhang Zhang

Professor

Email: zhangzhang (AT) big.ac.cn

Tel: +86 (10) 8409-7261

Chinese Name: 章张

PROFESSIONAL EXPERIENCE

  • Associate Director of National Genomics Data Center (NGDC), Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation (CNCB), China, 2020 - Present

  • BIG Distinguished Professor, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2017 - Present

  • Associate Director of BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2016 - 2020

  • Professor, University of Chinese Academy of Sciences, China, 2015 - Present

  • Professor in the CAS 100-Talent Program, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2011 - Present

  • Research Scientist, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia, 2009 - 2011

  • Postdoctoral Associate, Yale University, United States of America, 2007 - 2009

EDUCATION

  • PhD in Computer Science, Institute of Computing Technology, Chinese Academy of Sciences, China, 2007

  • MS in Computer Science, Nanjing University of Science and Technology, China, 2004

  • BS in Computer Science, Ningxia University, China, 2002

HONORS & AWARDS

  • 2021年中国科学院大学-BHPB导师科研奖（UCAS-BHPB Excellent Supervisor Award, November 2021）

  • 2020年中国科学院大学“领雁金奖”引航奖（UCAS Lingyan Golden Award, September 2020）

  • 2019年国家“万人计划”青年拔尖人才（National Ten Thousand Talent Program for Young Top-notch Talent, February 2019）

  • 2018年中国科学院大学-BHPB导师科研奖（UCAS-BHPB Excellent Supervisor Award, September 2018）

  • 2017年中国科学院北京基因组研究所特聘研究员（BIG Distinguished Professor, September 2017）

  • 2017年中国科学院“百人计划”终期评估优秀奖（Excellence Award in the Final Evaluation of the CAS 100-Talent Program, August 2017）

AWARDS OF SUPERVISED STUDENTS

  • 2021年中国科学院-必和必拓BHPB奖 - 滕徐菲

  • 2021年博士研究生国家奖学金 - 李昭

  • 2021年硕士研究生国家奖学金 - 朱彤彤

  • 2021年北京市普通高等学校优秀毕业生 - 刘琳

  • 2020年博士研究生国家奖学金 - 刘琳

  • 2020年硕士研究生国家奖学金 - 张源笙

  • 2020年第二届精准医学前沿研究生学术论坛论文荣誉奖 - 刘琳

  • 2020年第二届精准医学前沿研究生学术论坛最佳论文三等奖 - 滕徐菲

  • 2019年第四届国际生命与健康大数据论坛最佳报告奖 - 滕徐菲

  • 2019年北京市普通高等学校优秀毕业生 - 王佩

  • 2019年硕士研究生国家奖学金 - 王佩

  • 2019年北京市普通高等学校优秀毕业生 - 桑健

  • 2018年博士研究生国家奖学金 - 桑健

  • 2018年硕士研究生国家奖学金 - 曹佳宝

  • 2018年中国科学院-必和必拓BHPB奖 - 桑健

  • 2017年地奥奖学金 - 徐行健

RESEARCH INTERESTS

  • Big Data Integration and Curation: construction of multi-omics databases and knowledgebases by big data integration and curation and development of new theory for biological big data commons and ecosystem, with particular focuses on public health and national strategic important species.

    生物大数据整合审编与数据库系统研发：面向我国人口健康和重要战略生物资源，建立海量多组学数据资源体系，研发多层次组学数据库、信息库与知识库系统，发展生物大数据公共资源生态系统理论。

  • Computational Health Genomics: development of new methods and algorithms by associating omics data with health data and conducting integrative data analysis and deep mining via artificial intelligence and machine learning, with the aim to provide more effective ways for precision health and medical treatment for brain tumors, like glioma.

    健康基因组数据智能深度挖掘：围绕人类脑胶质瘤等重大疾病，基于人工智能、机器学习、统计学习等多学科前沿交叉技术，研发面向精准医学的肿瘤多组学数据与健康数据的整合分析和深度挖掘的新方法与新技术。

  • Computational Molecular Evolution: establishment of molecular evolutionary models and theories at the nucleotide and codon levels and development of new methods and tools for detecting national selection pressure.

    计算分子进化与自然选择压力检测：发展分子序列在核苷酸和密码子水平上的演化新模型和新理论，研发自然选择压力检测新方法与新技术。

TEACHING

  • Introduction to Omics (for graduates; in English)

  • Bioinformatics, Genomics, Big Data (for graduates; in Chinese)

  • Genomics (for undergraduates; in Chinese)

FEATURED PROJECTS & RESOURCES

ACADEMIC ACTIVITIES

PUBLICATIONS

  1. Zhang Z: KaKs_Calculator 3.0: Calculating selective pressure on coding and non-coding sequences. Genomics Proteomics Bioinformatics 2022. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34990803

  2. 李茹姣, 张欣, 宋述慧, 王彦青, 邹东, 肖景发, 赵文明, 章张, 鲍一明: 基因组科学数据的安全管理与应用. 大数据 2022, 8(1):37-45.

  3. Zhang Y, Zou D, Zhu T, Xu T, Chen M, Niu G, Zong W, Pan R, Jing W, Sang J, Liu C, Xiong Y, Sun Y, Zhai S, Chen H, Zhao W, Xiao J, Bao Y, Hao L, Zhang Z: Gene Expression Nebulas (GEN): a comprehensive data portal integrating transcriptomic profiles across multiple species at both bulk and single-cell levels. Nucleic Acids Res 2022, 50(D1):D1016-D1024. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34591957

  4. Xiong Z, Yang F, Li M, Ma Y, Zhao W, Wang G, Li Z, Zheng X, Zou D, Zong W, Kang H, Jia Y, Li R, Zhang Z, Bao Y: EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study. Nucleic Acids Res 2022, 50(D1):D1004-D1009. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718752

  5. Liu L, Zhang Y, Niu G, Li Q, Li Z, Zhu T, Feng C, Liu X, Zhang Y, Xu T, Chen R, Teng X, Zhang R, Zou D, Ma L, Zhang Z: BrainBase: a curated knowledgebase for brain diseases. Nucleic Acids Res 2022, 50(D1):D1131-D1138. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718720

  6. Liu L, Li Z, Liu C, Zou D, Li Q, Feng C, Jing W, Luo S, Zhang Z, Ma L: LncRNAWiki 2.0: a knowledgebase of human long non-coding RNAs with enhanced curation model and database system. Nucleic Acids Res 2022, 50(D1):D190-D195. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34751395

  7. Jiang S, Du Q, Feng C, Ma L, Zhang Z: CompoDynamics: a comprehensive database for characterizing sequence composition dynamics. Nucleic Acids Res 2022, 50(D1):D962-D969. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718745

  8. Jia L, Li Y, Huang F, Jiang Y, Li H, Wang Z, Chen T, Li J, Zhang Z, Yao W: LIRBase: a comprehensive database of long inverted repeats in eukaryotic genomes. Nucleic Acids Res 2022, 50(D1):D174-D182. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34643715

  9. CNCB-NGDC Members & Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022. Nucleic Acids Res 2022, 50(D1):D27-D38. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718731

  10. Chen T, Chen X, Zhang S, Zhu J, Tang B, Wang A, Dong L, Zhang Z, Yu C, Sun Y, Chi L, Chen H, Zhai S, Sun Y, Lan L, Zhang X, Xiao J, Bao Y, Wang Y, Zhang Z, Zhao W: The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types. Genomics Proteomics Bioinformatics 2022:doi: 10.1016/j.gpb.2021.1008.1001. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34400360

  11. Chen M, Ma Y, Wu S, Zheng X, Kang H, Sang J, Xu X, Hao L, Li Z, Gong Z, Xiao J, Zhang Z, Zhao W, Bao Y: Genome Warehouse: A Public Repository Housing Genome-scale Data. Genomics Proteomics Bioinformatics 2022:doi: 10.1016/j.gpb.2021.1004.1001. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34175476

  12. Zhang SS, Chen X, Chen TT, Zhu JW, Tang BX, Wang AK, Dong LL, Zhang ZW, Sun YL, Yu CX, Zhai S, Sun YB, Chen HX, Du ZL, Xiao JF, Zhang Z, Bao YM, Wang YQ, Zhao WM: GSA-Human: Genome Sequence Archive for Human. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2021, 43(10):988-993. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34702711 

  13. The RNAcentral Consortium: RNAcentral 2021: secondary structure integration, improved sequence search and new member databases. Nucleic Acids Res 2021, 49(D1):D212-D220. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33106848

  14. Liu X, Wang P, Teng X, Zhang Z, Song S: Comprehensive Analysis of Expression Regulation for RNA m6A Regulators With Clinical Significance in Human Cancers. Front Oncol 2021, 11:624395. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33718187

  15. Li Z, Liu L, Jiang S, Li Q, Feng C, Du Q, Zou D, Xiao J, Zhang Z, Ma L: LncExpDB: an expression database of human long non-coding RNAs. Nucleic Acids Res 2021, 49(D1):D962-D968. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33045751

  16. Li C, Tian D, Tang B, Liu X, Teng X, Zhao W, Zhang Z, Song S: Genome Variation Map: a worldwide collection of genome variations across multiple species. Nucleic Acids Res 2021, 49(D1):D1186-D1191. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33170268

  17. CNCB-NGDC Members & Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. Nucleic Acids Res 2021, 49(D1):D18-D28. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33175170

  18. Zhao WM, Song SH, Chen ML, Zou D, Ma LN, Ma YK, Li RJ, Hao LL, Li CP, Tian DM, Tang BX, Wang YQ, Zhu JW, Chen HX, Zhang Z, Xue YB, Bao YM: The 2019 novel coronavirus resource. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2020, 42(2):212-221. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32102777

  19. Zhang Z, Song S, Yu J, Zhao W, Xiao J, Bao Y: The Elements of Data Sharing. Genomics Proteomics Bioinformatics 2020, 18(1):1-4. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32360769

  20. Yan J, Zou D, Li C, Zhang Z, Song S, Wang X: SR4R: An Integrative SNP Resource for Genomic Breeding and Population Research in Rice. Genomics Proteomics Bioinformatics 2020, 18(2):173-185. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32619768

  21. Xiong Z, Li M, Yang F, Ma Y, Sang J, Li R, Li Z, Zhang Z, Bao Y: EWAS Data Hub: a resource of DNA methylation array data and metadata. Nucleic Acids Res 2020, 48(D1):D890-D895. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31584095

  22. Tian D, Wang P, Tang B, Teng X, Li C, Liu X, Zou D, Song S, Zhang Z: GWAS Atlas: a curated resource of genome-wide variant-trait associations in plants and animals. Nucleic Acids Res 2020, 48(D1):D927-D932. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31566222

  23. Teng X, Li Q, Li Z, Zhang Y, Niu G, Xiao J, Yu J, Zhang Z, Song S: Compositional Variability and Mutation Spectra of Monophyletic SARS-CoV-2 Clades. Genomics Proteomics Bioinformatics 2020, 18(6):648-663. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33581339

  24. Song S, Ma L, Zou D, Tian D, Li C, Zhu J, Chen M, Wang A, Ma Y, Li M, Teng X, Cui Y, Duan G, Zhang M, Jin T, Shi C, Du Z, Zhang Y, Liu C, Li R, Zeng J, Hao L, Jiang S, Chen H, Han D, Xiao J, Zhang Z, Zhao W, Xue Y, Bao Y: The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR. Genomics Proteomics Bioinformatics 2020, 18(6):749-759. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33704069

  25. Sang J, Zou D, Wang Z, Wang F, Zhang Y, Xia L, Li Z, Ma L, Li M, Xu B, Liu X, Wu S, Liu L, Niu G, Li M, Luo Y, Hu S, Hao L, Zhang Z: IC4R-2.0: Rice Genome Reannotation Using Massive RNA-seq Data. Genomics Proteomics Bioinformatics 2020, 18(2):161-172. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32683045

  26. National Genomics Data Center Members & Partners: Database Resources of the National Genomics Data Center in 2020. Nucleic Acids Res 2020, 48(D1):D24-D33. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31702008

  27. Miao W, Song L, Ba S, Zhang L, Guan G, Zhang Z, Ning K: Protist 10,000 Genomes Project. Innovation (N Y) 2020, 1(3):100058. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34557722

  28. Liu L, Wang G, Wang L, Yu C, Li M, Song S, Hao L, Ma L, Zhang Z: Computational identification and characterization of glioma candidate biomarkers through multi-omics integrative profiling. Biol Direct 2020, 15(1):10. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32539851

  29. Li Z, Zhang Y, Zou D, Zhao Y, Wang HL, Zhang Y, Xia X, Luo J, Guo H, Zhang Z: LSD 3.0: a comprehensive resource for the leaf senescence research community. Nucleic Acids Res 2020, 48(D1):D1069-D1075. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31599330

  30. Li Q, Li Z, Feng C, Jiang S, Zhang Z, Ma L: Multi-omics annotation of human long non-coding RNAs. Biochem Soc Trans 2020, 48(4):1545-1556. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32756901

  31. Gong Z, Zhu JW, Li CP, Jiang S, Ma LN, Tang BX, Zou D, Chen ML, Sun YB, Song SH, Zhang Z, Xiao JF, Xue YB, Bao YM, Du ZL, Zhao WM: An online coronavirus analysis platform from the National Genomics Data Center. Zool Res 2020, 41(6):705-708. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33045776

  32. Zhao Y, Wang J, Liang F, Liu Y, Wang Q, Zhang H, Jiang M, Zhang Z, Zhao W, Bao Y, Zhang Z, Wu J, Asmann YW, Li R, Xiao J: NucMap: a database of genome-wide nucleosome positioning map across species. Nucleic Acids Res 2019, 47(D1):D163-D169. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30335176

  33. Zhang Z, Yu J, Eisenhaber F, Gao X, Gojobori T: In Memory of Vladimir B. Bajic (1952-2019). Genomics Proteomics & Bioinformatics 2019, 17(5):473-474. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-WOS:000518438500001

  34. Yin H, Li M, Xia L, He C, Zhang Z: Computational determination of gene age and characterization of evolutionary dynamics in human. Brief Bioinform 2019, 20(6):2141-2149. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30184145

  35. Wang G, Yin H, Li B, Yu C, Wang F, Xu X, Cao J, Bao Y, Wang L, Abbasi AA, Bajic VB, Ma L, Zhang Z: Characterization and identification of long non-coding RNAs based on feature relationship. Bioinformatics 2019, 35(17):2949-2956. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30649200

  36. The RNAcentral Consortium: RNAcentral: a hub of information for non-coding RNA sequences. Nucleic Acids Res 2019, 47(D1):D221-D229. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30395267

  37. Tang B, Zhou Q, Dong L, Li W, Zhang X, Lan L, Zhai S, Xiao J, Zhang Z, Bao Y, Zhang YP, Wang GD, Zhao W: iDog: an integrated resource for domestic dogs and wild canids. Nucleic Acids Res 2019, 47(D1):D793-D800. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30371881

  38. Song S, Zhang Z: Database Resources in BIG Data Center: Submission, Archiving, and Integration of Big Data in Plant Science. Molecular plant 2019, 12(3):279-281. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30716410

  39. Pervaiz N, Shakeel N, Qasim A, Zehra R, Anwar S, Rana N, Xue Y, Zhang Z, Bao Y, Abbasi AA: Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals. BMC Evol Biol 2019, 19(1):128. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31221090

  40. Niu G, Zou D, Li M, Zhang Y, Sang J, Xia L, Li M, Liu L, Cao J, Zhang Y, Wang P, Hu S, Hao L, Zhang Z: Editome Disease Knowledgebase (EDK): a curated knowledgebase of editome-disease associations in human. Nucleic Acids Res 2019, 47(D1):D78-D83. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30357418

  41. Ma L, Cao J, Liu L, Li Z, Shireen H, Pervaiz N, Batool F, Raza RZ, Zou D, Bao Y, Abbasi AA, Zhang Z: Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook. Curr Protoc Bioinformatics 2019, 67(1):e82. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31524988

  42. Ma L, Cao J, Liu L, Du Q, Li Z, Zou D, Bajic VB, Zhang Z: LncBook: a curated knowledgebase of human long non-coding RNAs. Nucleic Acids Res 2019, 47(D1):D128-D134. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30329098

  43. Li M, Zou D, Li Z, Gao R, Sang J, Zhang Y, Li R, Xia L, Zhang T, Niu G, Bao Y, Zhang Z: EWAS Atlas: a curated knowledgebase of epigenome-wide association studies. Nucleic Acids Res 2019, 47(D1):D983-D988. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30364969

  44. Li M, Xia L, Zhang Y, Niu G, Li M, Wang P, Zhang Y, Sang J, Zou D, Hu S, Hao L, Zhang Z: Plant editosome database: a curated database of RNA editosome in plants. Nucleic Acids Res 2019, 47(D1):D170-D174. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30364952

  45. BIG Data Center Members: Database Resources of the BIG Data Center in 2019. Nucleic Acids Res 2019, 47(D1):D8-D14. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30365034

  46. Zhang Z, Xue Y, Zhao F: Bioinformatics Commons: The Cornerstone of Life and Health Sciences. Genomics Proteomics Bioinformatics 2018, 16(4):223-225. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30268933

  47. Song S, Tian D, Zhang Z, Hu S, Yu J: Rice Genomics: over the Past Two Decades and into the Future. Genomics Proteomics Bioinformatics 2018, 16(6):397-404. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30771506

  48. Song S, Tian D, Li C, Tang B, Dong L, Xiao J, Bao Y, Zhao W, He H, Zhang Z: Genome Variation Map: a data repository of genome variations in BIG Data Center. Nucleic Acids Res 2018, 46(D1):D944-D949. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29069473

  49. Sang J, Wang Z, Li M, Cao J, Niu G, Xia L, Zou D, Wang F, Xu X, Han X, Fan J, Yang Y, Zuo W, Zhang Y, Zhao W, Bao Y, Xiao J, Hu S, Hao L, Zhang Z: ICG: a wiki-driven knowledgebase of internal control genes for RT-qPCR normalization. Nucleic Acids Res 2018, 46(D1):D121-D126. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29036693

  50. Li R, Liang F, Li M, Zou D, Sun S, Zhao Y, Zhao W, Bao Y, Xiao J, Zhang Z: MethBank 3.0: a database of DNA methylomes across a variety of species. Nucleic Acids Res 2018, 46(D1):D288-D295. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29161430

  51. International Society for Biocuration: Biocuration: Distilling data into knowledge. PLOS Biology 2018, 16(4):e2002846. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29659566

  52. BIG Data Center Members: Database Resources of the BIG Data Center in 2018. Nucleic Acids Research 2018, 46(D1):D14-D20. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29036542

  53. Zhao ZM, Campbell MC, Li N, Lee DSW, Zhang Z, Townsend JP: Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence. Mol Biol Evol 2017, 34(11):3006-3022. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28962009

  54. Xu X, Ji Z, Zhang Z: CloudPhylo: a fast and scalable tool for phylogeny reconstruction. Bioinformatics 2017, 33(3):438-440. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28172557

  55. Xia L, Zou D, Sang J, Xu X, Yin H, Li M, Wu S, Hu S, Hao L, Zhang Z: Rice Expression Database (RED): An integrated RNA-Seq-derived gene expression database for rice. J Genet Genomics 2017, 44(5):235-241. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28529082

  56. Wang Y, Song F, Zhu J, Zhang S, Yang Y, Chen T, Tang B, Dong L, Ding N, Zhang Q, Bai Z, Dong X, Chen H, Sun M, Zhai S, Sun Y, Yu L, Lan L, Xiao J, Fang X, Lei H, Zhang Z, Zhao W: GSA: Genome Sequence Archive. Genomics Proteomics Bioinformatics 2017, 15(1):14-18. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28387199

  57. The RNAcentral Consortium, Petrov AI, Kay SJE, Kalvari I, Howe KL, Gray KA, Bruford EA, Kersey PJ, Cochrane G, Finn RD, Bateman A, Kozomara A, Griffiths-Jones S, Frankish A, Zwieb CW, Lau BY, Williams KP, Chan PP, Lowe TM, Cannone JJ, Gutell R, Machnicka MA, Bujnicki JM, Yoshihama M, Kenmochi N, Chai B, Cole JR, Szymanski M, Karlowski WM, Wood V, Huala E, Berardini TZ, Zhao Y, Chen R, Zhu W, Paraskevopoulou MD, Vlachos IS, Hatzigeorgiou AG, Ma L, Zhang Z, Puetz J, Stadler PF, McDonald D, Basu S, Fey P, Engel SR, Cherry JM, Volders PJ, Mestdagh P, Wower J, Clark MB, Quek XC, Dinger ME: RNAcentral: a comprehensive database of non-coding RNA sequences. Nucleic Acids Res 2017, 45(D1):D128-D134. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27794554

  58. Salhi A, Essack M, Alam T, Bajic VP, Ma L, Radovanovic A, Marchand B, Schmeier S, Zhang Z, Bajic VB: DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining. RNA Biol 2017, 14(7):963-971. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28387604

  59. BIG Data Center Members: The BIG Data Center: from deposition to integration to translation. Nucleic Acids Res 2017, 45(D1):D18-D24. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27899658

  60. Zhao W, Zhang S, Tang B, Chen T, Hao L, Sang J, Li R, Xiao J, Zhang Z: Constructing the international database management system for omics big data. Big Data Research 2016, 2(6):43-52.

  61. Yin HY, Ma LN, Wang GY, Li MW, Zhang Z: Old genes experience stronger translational selection than young genes. Gene 2016, 590(1):29-34. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-WOS:000381539800004

  62. Yin H, Wang G, Ma L, Yi SV, Zhang Z: What Signatures Dominantly Associate with Gene Age? Genome Biol Evol 2016, 8(10):3083-3089. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27609935

  63. Xue Y, Lameijer EW, Ye K, Zhang K, Chang S, Wang X, Wu J, Gao G, Zhao F, Li J, Han C, Xu S, Xiao J, Yang X, Ying X, Zhang X, Chen WH, Liu Y, Zhang Z, Huang K, Yu J: Precision Medicine: What Challenges Are We Facing? Genomics Proteomics Bioinformatics 2016, 14(5):253-261. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-27744061

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  78. Wu H, Fang Y, Yu J, Zhang Z: The quest for a unified view of bacterial land colonization. The ISME journal 2014, 8(7):1358-1369. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-24451209

  79. Wu G, Zhu J, Yu J, Zhou L, Huang JZ, Zhang Z: Evaluation of five methods for genome-wide circadian gene identification. Journal of biological rhythms 2014, 29(4):231-242. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-25238853

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  82. Zhang Z, Yu J: Does the genetic code have a eukaryotic origin? Genomics Proteomics Bioinformatics 2013, 11(1):41-55. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23402863

  83. Wu J, Xiao J, Wang L, Zhong J, Yin H, Wu S, Zhang Z, Yu J: Systematic analysis of intron size and abundance parameters in diverse lineages. Sci China Life Sci 2013, 56(10):968-974. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-24022126

  84. Tong X, Yang Y, Wang W, Bai Z, Ma L, Zheng X, Sun H, Zhang Z, Zhao M, Yu J, Ge RL: Expression profiling of abundant genes in pulmonary and cardiac muscle tissues of Tibetan Antelope (Pantholops hodgsonii). Gene 2013, 523(2):187-191. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-23612247

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SELECTED INVITED TALKS

  1. Biological Big Data Deposition, Public Sharing and Database Resources. The 10th National Conference on Bioinformatics and System Biology of China, Chengdu, October 25-29, 2021.

  2. Database Resources of the National Genomics Data Center. The 9th National Conference on Bioinformatics and System Biology of China, Shanghai, September 26-29, 2020.

  3. Computational genomics of brain tumors: glioma biomarker identification and characterization through multi-omics integrative molecular profiling. KAUST Research Conference Digital Health 2020, Thuwal, Saudi Arabia, January 20-22, 2020.

  4. Building a big data ecosystem for bioinformatics. The 4th Annual European Bioinformatics Core Community Workshop, Basel, Switzerland, 26 July 2019.

  5. 生命组学大数据管理与资源体系建设, 中国科学院青年创新促进会第一届青年生命科学论坛, 乌鲁木齐, 2019年7月12-16日.

  6. 生命组学数据资源体系建设, 第六届全国计算生物学与生物信息学学术会议, 成都, 2019年3月30-31日.

  7. Database Resources of the BIG Data Center in 2018. International Conference on Precision Medicine, Bangkok, Thailand, 19-20 July 2018.

  8. 基因大数据汇交共享与多组学数据资源体系建设, 北京生物信息学系列论坛, 北京大学, 2018年1月19日

  9. The BIG Data Center: from deposition to integration to translation. The Sino-ASEAN Conference on Precision Medicine, Burapha University, Thailand, 17-18 June 2017.

  10. The BIG Data Center’s database resources: towards precision medicine . The 10th International Biocuration Conference, Stanford University, United States, 26-29 March 2017.

  11. The BIG Data Center: from deposition to integration to translation. The 4th Youth Forum for Computer & Life Sciences Interdisciplinary Research (第四届数学、计算机与生命科学交叉研究青年学者论坛), Beijing, China, May 21-22, 2016.

  12. The BIG Data Center for Life and Health Sciences. The Phoenix City Forum for Genome Informatics (基因组信息学凤凰城论坛), Tangshan, China, May 13-15, 2016.

  13. The BIG Data Center: from deposition to integration to translation. The 9th International Biocuration Conference, Geneva, Switzerland, April 10-14, 2016.

  14. Big Data integration: scalability and sustainability. KAUST Research Conference on Computational and Experimental Interfaces of Big Data and Biotechnology, Thuwal, Saudi Arabia, Jan. 25-27, 2016.

  15. Toward Sustainability and Scalability for Big Data Integration. 2015 Functional Genomics Summit II, Beijing, China, Nov. 11-12, 2015.

  16. Community integration of big data. The 2015 International Conference of Genomics, Xi'an, China, Oct. 22-25, 2015.

  17. Bringing biocuration to China. The 1st International Coastal Biology Congress, Yantai, China, Sept. 26-30, 2014.

  18. Big data integration, curation, and analysis. The 3rd Young Bioinformatics PI Workshop, Guangzhou, China, Sept. 19-21, 2014.

  19. Biocuration in the era of big data. The Workshop on Statistical and Computational Theory and Methodology for Big Data Analysis, Banff, Canada, Feb. 9-14, 2014.

  20. Community curation in biological knowledge wikis. The 6th International Biocuration Conference, Churchill College, Cambridge, United Kingdom, April 7-10, 2013.

  21. Rewarding community-curated contributions in biological knowledge wikis. The High-throughput Sequencing Data Analysis and Approaches Workshop, Beijing, China, Dec. 5-7, 2012.

  22. Next-Generation Bioinformatics: harnessing collective resources for large-scale data manipulation, in workshop “Challenges and future of Bioinformatics: sharing insights from the Dutch and Chinese perspective”, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China, March 19, 2012.