Yuzhu Chen JL, Yufeng Zhang, Mingqian Zhang, Zheng Sun, Gongchao Jing, Shi Huang , Xiaoquan Su. Parallel-Meta Suite: interactive and rapid microbiome data analysis on multiple platforms. 2022.
https://github.com/qdu-bioinfo/parallel-meta-suite

Candidate biomarker selection by regression

Calculate the correlation coefficient and P value between the feature table and the numerical data in the metadata. The calculated correlation coefficient and adjusted P-value are then saved to a file and the features are sorted by correlation strength. For each metadata variable, a scatterplot PDF containing significantly correlated features is generated. The graph shows the correlation coefficient, P value, and fitted regression line.